Search Results - "Oehler, Leopold"

The AST/ALT (De Ritis) ratio predicts clinical outcome in patients with pancreatic cancer treated with first-line nab-paclitaxel and gemcitabine: post hoc analysis of an Austrian multicenter, noninterventional study by Riedl, Jakob Michael, Posch, Florian, Prager, Gerald, Eisterer, Wolfgang, Oehler, Leopold, Sliwa, Thamer, Wilthoner, Klaus, Petzer, Andreas, Pichler, Petra, Hubmann, Eva, Winder, Thomas, Burgstaller, Sonja, Korger, Markus, Andel, Johannes, Greil, Richard, Neumann, Hans-Joerg, Pecherstorfer, Martin, Philipp-Abbrederis, Kathrin, Djanani, Angela, Gruenberger, Birgit, Laengle, Friedrich, Wöll, Ewald, Gerger, Armin

“…Background: The pretreatment De Ritis ratio [aspartate transaminase (AST)/alanine transaminase (ALT)] has been shown to be an adverse prognostic marker in…”
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Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial by Bartsch, Rupert, Berghoff, Anna Sophie, Furtner, Julia, Marhold, Maximilian, Bergen, Elisabeth Sophie, Roider-Schur, Sophie, Starzer, Angelika Martina, Forstner, Heidrun, Rottenmanner, Beate, Dieckmann, Karin, Bago-Horvath, Zsuzsanna, Haslacher, Helmuth, Widhalm, Georg, Ilhan-Mutlu, Aysegül, Minichsdorfer, Christoph, Fuereder, Thorsten, Szekeres, Thomas, Oehler, Leopold, Gruenberger, Birgit, Singer, Christian F., Weltermann, Ansgar, Puhr, Rainer, Preusser, Matthias

“…Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive metastatic…”
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Severe enteropathy associated with raltitrexed and oxaliplatin chemotherapy: report of two patients experiencing this rare, potentially lethal gastrointestinal adverse event by Wenzel, Catharina, Urbauer, Eleonora, Schwarz, Christoph, Funk, Georg, Oehler, Leopold, Kornek, Gabriela V, Scheithauer, Werner

“…Among the several different combination chemotherapy regimens for the treatment of patients with metastatic colorectal cancer, oxaliplatin plus raltitrexed has…”
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Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders by Kornauth, Christoph, Pemovska, Tea, Vladimer, Gregory I, Bayer, Günther, Bergmann, Michael, Eder, Sandra, Eichner, Ruth, Erl, Martin, Esterbauer, Harald, Exner, Ruth, Felsleitner-Hauer, Verena, Forte, Maurizio, Gaiger, Alexander, Geissler, Klaus, Greinix, Hildegard T, Gstöttner, Wolfgang, Hacker, Marcus, Hartmann, Bernd Lorenz, Hauswirth, Alexander W, Heinemann, Tim, Heintel, Daniel, Hoda, Mir Alireza, Hopfinger, Georg, Jaeger, Ulrich, Kazianka, Lukas, Kenner, Lukas, Kiesewetter, Barbara, Krall, Nikolaus, Krajnik, Gerhard, Kubicek, Stefan, Le, Trang, Lubowitzki, Simone, Mayerhoefer, Marius E, Menschel, Elisabeth, Merkel, Olaf, Miura, Katsuhiro, Müllauer, Leonhard, Neumeister, Peter, Noesslinger, Thomas, Ocko, Katharina, Öhler, Leopold, Panny, Michael, Pichler, Alexander, Porpaczy, Edit, Prager, Gerald W, Raderer, Markus, Ristl, Robin, Ruckser, Reinhard, Salamon, Julius, Schiefer, Ana-Iris, Schmolke, Ann-Sofie, Schwarzinger, Ilse, Selzer, Edgar, Sillaber, Christian, Skrabs, Cathrin, Sperr, Wolfgang R, Srndic, Ismet, Thalhammer, Renate, Valent, Peter, van der Kouwe, Emiel, Vanura, Katrina, Vogt, Stefan, Waldstein, Cora, Wolf, Dominik, Zielinski, Christoph C, Zojer, Niklas, Simonitsch-Klupp, Ingrid, Superti-Furga, Giulio, Snijder, Berend, Staber, Philipp B

“…Personalized medicine aims to match the right drug with the right patient by using specific features of the individual patient's tumor. However, current…”
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Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational CORRELATE study by Ducreux, Michel, Petersen, Lone Nørgård, Öhler, Leopold, Bergamo, Francesca, Metges, Jean-Philippe, de Groot, Jan Willem, Wang, Jaw-Yuan, García Paredes, Beatriz, Dochy, Emmanuelle, Fiala-Buskies, Sabine, Cervantes, Andrés, O'Connor, Juan Manuel, Falcone, Alfredo

“…Regorafenib prolonged overall survival (OS) versus placebo in patients with treatment-refractory metastatic colorectal cancer (mCRC) in phase III trials. We…”
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Myelomonocytic skewing in chronic myelomonocytic leukemia: phenotypic, molecular and biologic features and impact on survival by Geissler, Klaus, Jäger, Eva, Barna, Agnes, Graf, Temeida, Graf, Elmir, Öhler, Leopold, Hoermann, Gregor, Valent, Peter

“…Background Myelomonocytic skewing is considered as a key pathophysiologic phenomenon in chronic myelomonocytic leukemia (CMML), but its prevalence and…”
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Activity of T-DM1 in Her2-positive breast cancer brain metastases by Bartsch, Rupert, Berghoff, Anna S., Vogl, Ursula, Rudas, Margaretha, Bergen, Elisabeth, Dubsky, Peter, Dieckmann, Karin, Pinker, Katja, Bago-Horvath, Zsuzsanna, Galid, Arik, Oehler, Leopold, Zielinski, Christoph C., Gnant, Michael, Steger, Guenther G., Preusser, Matthias

“…Brain metastases (BM) are frequently diagnosed in metastatic Her2-positive breast cancer. Local treatment remains the standard of care but lapatinib plus…”
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Comparison of nab-paclitaxel plus gemcitabine in elderly versus younger patients with metastatic pancreatic cancer: Analysis of a multicentre, prospective, non-interventional study by Prager, Gerald W., Oehler, Leopold, Gerger, Armin, Mlineritsch, Brigitte, Andel, Johannes, Petzer, Andreas, Wilthoner, Klaus, Sliwa, Thamer, Pichler, Petra, Winder, Thomas, Heibl, Sonja, Gruenberger, Birgit, Laengle, Friedrich, Hubmann, Eva, Korger, Markus, Pecherstorfer, Martin, Djanani, Angela, Neumann, Hans-Joerg, Philipp-Abbrederis, Kathrin, Wöll, Ewald, Trondl, Robert, Arnold-Schrauf, Catharina, Eisterer, Wolfgang

“…Pancreatic cancer (PC) ranks among the deadliest malignancies worldwide. In the MPACT study, first-line nab-paclitaxel plus gemcitabine (nab-P/G) demonstrated…”
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Final outcome analysis from the phase II TUXEDO-1 trial of trastuzumab-deruxtecan in HER2-positive breast cancer patients with active brain metastases by Bartsch, Rupert, Berghoff, Anna Sophie, Furtner, Julia, Marhold, Maximilian, Bergen, Elisabeth Sophie, Roider-Schur, Sophie, Mair, Maximilian Johannes, Starzer, Angelika Martina, Forstner, Heidrun, Rottenmanner, Beate, Aretin, Marie-Bernadette, Dieckmann, Karin, Bago-Horvath, Zsuzsanna, Haslacher, Helmuth, Widhalm, Georg, Ilhan-Mutlu, Aysegül, Minichsdorfer, Christoph, Fuereder, Thorsten, Szekeres, Thomas, Oehler, Leopold, Gruenberger, Birgit, Pfeiler, Georg, Singer, Christian, Weltermann, Ansgar, Berchtold, Luzia, Preusser, Matthias

“…Brain metastases (BM) are a devastating complication of HER2-positive metastatic breast cancer (BC) and treatment strategies providing optimized local and…”
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Multistep pathogenesis of chronic myelomonocytic leukemia in patients by Geissler, Klaus, Jäger, Eva, Barna, Agnes, Gurbisz, Michael, Marschon, Renate, Graf, Temeida, Nösslinger, Thomas, Pfeilstöcker, Michael, Machherndl‐Spandl, Sigrid, Stauder, Reinhard, Zebisch, Armin, Sill, Heinz, Öhler, Leopold, Kusec, Rajko, Hoermann, Gregor, Valent, Peter

“…Background A multistep pathogenesis of myeloid leukemia including mutations in epigenetic, spliceosome, and signaling genes has been recently demonstrated in a…”
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REGO-ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer by Piringer, Gudrun, Vormittag, Laurenz, Öhler, Leopold, Grünberger, Birgit, Meran, Johannes, Moshammer, Marlies, Andel, Johannes, Eisterer, Wolfgang, Trommet, Vera, Thaler, Josef

“…Summary Background A frequent side effect of the multikinase inhibitor regorafenib is fatigue. Physical activity has shown potential in reducing cancer-related…”
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Abstract PO3-16-10: Real-world outcomes with first-line ribociclib + endocrine therapy in patients with metastatic HR+, HER2– breast cancer: Fourth interim analysis of REACH AUT trial by Singer, Christian F., Egle, Daniel, Greil, Richard, Petru, Edgar, Oehler, Leopold, Balic, Marija, Schöffmann, Laurenz, Pfeiler, Georg, Marhold, Maximilian, Brunner, Christine, Haider, Karin, Galid, Arik, Pluschnig, Ursula, Haslbauer, Ferdinand, Hubalek, Michael, Redl, Andreas, Flatschacher, Julia, Uthman, Shanow, Mraz, Bernhard, Bartsch, Rupert

“…Abstract Background: Ribociclib (RIB), a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) in combination with endocrine therapy (ET) yielded significant…”
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Evaluation of Prognostic Immune Signatures in Patients with Breast, Colorectal and Pancreatic Cancer Receiving Chemotherapy by Vogl, Ursula M, Öhler, Leopold, Rasic, Masa, Frischer, Josa M, Modak, Madhura, Stöckl, Johannes

“…CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) receptor family and is dominantly expressed on immune cells and in a variety of…”
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SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study by Berger, Julia M., Wohlfarth, Phillipp, Königsbrügge, Oliver, Knaus, Hanna A., Porpaczy, Edit, Kaufmann, Hannes, Schreiber, Johanna, Mrva-Ghukasyan, Tatevik, Winder, Thomas, Severgnini, Luciano, Wolf, Dominik, Petzer, Verena, Nguyen, Van Anh, Weinlich, Georg, Öhler, Leopold, Wonnerth, Anna, Miksovsky, Aurelia, Engelhart, Bert, Preusser, Matthias, Berghoff, Anna S.

“…Summary Background Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here,…”
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Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients by Geissler, Klaus, Jäger, Eva, Barna, Agnes, Gurbisz, Michael, Graf, Temeida, Graf, Elmir, Nösslinger, Thomas, Pfeilstöcker, Michael, Tüchler, Heinz, Sliwa, Thamer, Keil, Felix, Geissler, Christoph, Heibl, Sonja, Thaler, Josef, Machherndl-Spandl, Sigrid, Zach, Otto, Weltermann, Ansgar, Bettelheim, Peter, Stauder, Reinhard, Zebisch, Armin, Sill, Heinz, Schwarzinger, Ilse, Schneeweiss, Bruno, Öhler, Leopold, Ulsperger, Ernst, Kusec, Rajko, Germing, Ulrich, Sperr, Wolfgang R, Knöbl, Paul, Jäger, Ulrich, Hörmann, Gregor, Valent, Peter

“…Although the RAS-pathway has been implicated as an important driver in the pathogenesis of chronic myelomonocytic leukemia (CMML) a comprehensive study…”
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Efficacy and safety of everolimus plus exemestane in patients with HR+, HER2− advanced breast cancer progressing on/after prior endocrine therapy in routine clinical practice: Primary results from the non-interventional study, STEPAUT by Steger, Guenther G., Egle, Daniel, Bartsch, Rupert, Pfeiler, Georg, Petru, Edgar, Greil, Richard, Helfgott, Ruth, Marth, Christian, Öhler, Leopold, Hubalek, Michael, Lang, Alois, Tinchon, Christoph, Haslbauer, Ferdinand, Redl, Andreas, Hock, Karin, Hennebelle, Mathias, Mraz, Bernhard, Gnant, Michael

“…STEPAUT, an Austrian non-interventional study, evaluated the safety and efficacy of everolimus plus exemestane in patients with hormone receptor-positive…”
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Molecular Basis and Clinical Application of Growth-Factor-Independent In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia by Geissler, Klaus, Jäger, Eva, Barna, Agnes, Gurbisz, Michael, Graf, Temeida, Graf, Elmir, Nösslinger, Thomas, Pfeilstöcker, Michael, Machherndl-Spandl, Sigrid, Stauder, Reinhard, Zebisch, Armin, Sill, Heinz, Öhler, Leopold, Kusec, Rajko, Hörmann, Gregor, Valent, Peter

“…We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia…”
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Abstract PO2-04-05: FINAL OUTCOME ANALYSIS FROM THE PHASE II TUXEDO-1 TRIAL OF TRASTUZUMAB-DERUXTECAN IN HER2-POSITIVE BREAST CANCER PATIENTS WITH ACTIVE BRAIN METASTASES by Bartsch, Rupert, Berghoff, Anna Sophie, Furtner, Julia, Marhold, Maximilian, Bergen, Elisabeth Sophie, Roider-Schur, Sophie, Starzer, Angelika Maria, Mair, Maximilian, Forstner, Heidrun, Rottenmanner, Beate, Aretin, Marie-Bernadette, Dieckmann, Karin, Bago-Horvath, Zsuzsanna, Haslacher, Helmuth, Widhalm, Georg, Ilhan-Mutlu, Aysegül, Minichsdorfer, Christoph, Fuereder, Thorsten, Szekeres, Thomas, Oehler, Leopold, Gruenberger, Birgit, Pfeiler, Georg, Singer, Christian F., Weltermann, Ansgar, Berchtold, Luzia, Preusser, Matthias

“…Abstract Background Brain metastases (BM) are a severe complication of HER2-positive metastatic breast cancer. In the absence of any immediate indication for…”
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The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML): A representative and useful real-life data source for further biomedical research by Geissler, Klaus, Jäger, Eva, Barna, Agnes, Gurbisz, Michael, Marschon, Renate, Graf, Temeida, Graf, Elmir, Borjan, Bojana, Jilch, Ruth, Geissler, Christoph, Hoermann, Gregor, Esterbauer, Harald, Schwarzinger, Ilse, Nösslinger, Thomas, Pfeilstöcker, Michael, Tüchler, Heinz, Reisner, Regina, Sliwa, Thamer, Keil, Felix, Bettelheim, Peter, Machherndl-Spandl, Sigrid, Doleschal, Bernhard, Zach, Otto, Weltermann, Ansgar, Heibl, Sonja, Thaler, Josef, Zebisch, Armin, Sill, Heinz, Stauder, Reinhard, Webersinke, Gerald, Petzer, Andreas, Kusec, Rajko, Ulsperger, Ernst, Schneeweiss, Bruno, Berger, Jörg, Öhler, Leopold, Germing, Ulrich, Sperr, Wolfgang R., Knöbl, Paul, Jäger, Ulrich, Valent, Peter

“…Summary In the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) clinicolaboratory real-life data have been captured from 606 CMML patients…”
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Interleukin-10 inhibits autonomous myelopoiesis in patients with myelofibrosis by Geissler, Klaus, Jäger, Eva, Öhler, Leopold, Gisslinger, Heinz, Jäger, Ulrich, Lechner, Klaus

“…The spontaneous formation of colony‐forming units granulocyte/macrophage (CFU‐GM) in semisolid cultures has been shown to be due to the endogenous release of…”
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