Search Results - "Oefner, Peter. J"

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells by Brand, Almut, Singer, Katrin, Koehl, Gudrun E., Kolitzus, Marlene, Schoenhammer, Gabriele, Thiel, Annette, Matos, Carina, Bruss, Christina, Klobuch, Sebastian, Peter, Katrin, Kastenberger, Michael, Bogdan, Christian, Schleicher, Ulrike, Mackensen, Andreas, Ullrich, Evelyn, Fichtner-Feigl, Stefan, Kesselring, Rebecca, Mack, Matthias, Ritter, Uwe, Schmid, Maximilian, Blank, Christian, Dettmer, Katja, Oefner, Peter J., Hoffmann, Petra, Walenta, Stefan, Geissler, Edward K., Pouyssegur, Jacques, Villunger, Andreas, Steven, André, Seliger, Barbara, Schreml, Stephan, Haferkamp, Sebastian, Kohl, Elisabeth, Karrer, Sigrid, Berneburg, Mark, Herr, Wolfgang, Mueller-Klieser, Wolfgang, Renner, Kathrin, Kreutz, Marina

“…Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid…”
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Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice by Loftus, Róisín M., Assmann, Nadine, Kedia-Mehta, Nidhi, O’Brien, Katie L., Garcia, Arianne, Gillespie, Conor, Hukelmann, Jens L., Oefner, Peter J., Lamond, Angus I., Gardiner, Clair M., Dettmer, Katja, Cantrell, Doreen A., Sinclair, Linda V., Finlay, David K.

“…Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation…”
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Automated GC–MS analysis of free amino acids in biological fluids by Kaspar, Hannelore, Dettmer, Katja, Gronwald, Wolfram, Oefner, Peter J.

“…A gas chromatography–mass spectrometry (GC–MS) method was developed for the quantitative analysis of free amino acids as their propyl chloroformate derivatives…”
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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen by Siegert, Isabel, Schödel, Johannes, Nairz, Manfred, Schatz, Valentin, Dettmer, Katja, Dick, Christopher, Kalucka, Joanna, Franke, Kristin, Ehrenschwender, Martin, Schley, Gunnar, Beneke, Angelika, Sutter, Jörg, Moll, Matthias, Hellerbrand, Claus, Wielockx, Ben, Katschinski, Dörthe M., Lang, Roland, Galy, Bruno, Hentze, Matthias W., Koivunen, Peppi, Oefner, Peter J., Bogdan, Christian, Weiss, Günter, Willam, Carsten, Jantsch, Jonathan

“…Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a…”
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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans by Schlosser, Pascal, Li, Yong, Sekula, Peggy, Raffler, Johannes, Grundner-Culemann, Franziska, Pietzner, Maik, Cheng, Yurong, Wuttke, Matthias, Steinbrenner, Inga, Schultheiss, Ulla T., Kotsis, Fruzsina, Kacprowski, Tim, Forer, Lukas, Hausknecht, Birgit, Ekici, Arif B., Nauck, Matthias, Völker, Uwe, Walz, Gerd, Oefner, Peter J., Kronenberg, Florian, Mohney, Robert P., Köttgen, Michael, Suhre, Karsten, Eckardt, Kai-Uwe, Kastenmüller, Gabi, Köttgen, Anna

“…The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites…”
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Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages by Dowling, Jennifer K., Afzal, Remsha, Gearing, Linden J., Cervantes-Silva, Mariana P., Annett, Stephanie, Davis, Gavin M., De Santi, Chiara, Assmann, Nadine, Dettmer, Katja, Gough, Daniel J., Bantug, Glenn R., Hamid, Fidinny I., Nally, Frances K., Duffy, Conor P., Gorman, Aoife L., Liddicoat, Alex M., Lavelle, Ed C., Hess, Christoph, Oefner, Peter J., Finlay, David K., Davey, Gavin P., Robson, Tracy, Curtis, Annie M., Hertzog, Paul J., Williams, Bryan R. G., McCoy, Claire E.

“…Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10)…”
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CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles by BEIER, Dagmar, HAU, Peter, PROESCHOLDT, Martin, LOHMEIER, Annette, WISCHHUSEN, Jörg, OEFNER, Peter J, AIGNER, Ludwig, BRAWANSKI, Alexander, BOGDAHN, Ulrich, BEIER, Christoph P

“…Although glioblastomas show the same histologic phenotype, biological hallmarks such as growth and differentiation properties vary considerably between…”
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population by Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S, Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A, Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J, Valdes, Ana M, Meisinger, Christa, Coresh, Josef, Spector, Tim D, Mohney, Robert P, Suhre, Karsten, Kastenmüller, Gabi, Köttgen, Anna

“…Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and…”
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Arginase impedes the resolution of colitis by altering the microbiome and metabolome by Baier, Julia, Gänsbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Sören, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J, Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, Mattner, Jochen

“…Arginase 1 (Arg1), which converts l-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in…”
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Adjusting microbiome profiles for differences in microbial load by spike-in bacteria by Stämmler, Frank, Gläsner, Joachim, Hiergeist, Andreas, Holler, Ernst, Weber, Daniela, Oefner, Peter J, Gessner, André, Spang, Rainer

“…Next-generation 16S ribosomal RNA gene sequencing is widely used to determine the relative composition of the mammalian gut microbiomes. However, in the…”
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D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization by Böttcher, Martin, Renner, Kathrin, Berger, Raffaela, Mentz, Kristin, Thomas, Simone, Cardenas-Conejo, Zugey Elizabeth, Dettmer, Katja, Oefner, Peter J., Mackensen, Andreas, Kreutz, Marina, Mougiakakos, Dimitrios

“…D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase…”
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State-of-the art data normalization methods improve NMR-based metabolomic analysis by Kohl, Stefanie M., Klein, Matthias S., Hochrein, Jochen, Oefner, Peter J., Spang, Rainer, Gronwald, Wolfram

“…Extracting biomedical information from large metabolomic datasets by multivariate data analysis is of considerable complexity. Common challenges include among…”
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Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells by Schwab, Annemarie, Siddiqui, Aarif, Vazakidou, Maria Eleni, Napoli, Francesca, Böttcher, Martin, Menchicchi, Bianca, Raza, Umar, Saatci, Özge, Krebs, Angela M, Ferrazzi, Fulvia, Rapa, Ida, Dettmer-Wilde, Katja, Waldner, Maximilian J, Ekici, Arif B, Rasheed, Suhail Ahmed Kabeer, Mougiakakos, Dimitrios, Oefner, Peter J, Sahin, Ozgur, Volante, Marco, Greten, Florian R, Brabletz, Thomas, Ceppi, Paolo

“…Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene…”
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Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes by Dietl, Katrin, Renner, Kathrin, Dettmer, Katja, Timischl, Birgit, Eberhart, Karin, Dorn, Christoph, Hellerbrand, Claus, Kastenberger, Michael, Kunz-Schughart, Leoni A, Oefner, Peter J, Andreesen, Reinhard, Gottfried, Eva, Kreutz, Marina P

“…High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To…”
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Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin by LOTTAZ, Claudio, BEIER, Dagmar, SPANG, Rainer, STORCH, Alexander, BEIER, Christoph P, MEYER, Katharina, KUMAR, Praveen, HERMANN, Andreas, SCHWARZ, Johannes, JUNKER, Markus, OEFNER, Peter J, BOGDAHN, Ulrich, WISCHHUSEN, Jörg

“…Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Growing evidence suggests that different types…”
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Metabolite extraction from adherently growing mammalian cells for metabolomics studies: optimization of harvesting and extraction protocols by Dettmer, Katja, Nürnberger, Nadine, Kaspar, Hannelore, Gruber, Michael A, Almstetter, Martin F, Oefner, Peter J

“…Trypsin/ethylenediaminetetraacetic acid (EDTA) treatment and cell scraping in a buffer solution were compared for harvesting adherently growing mammalian SW480…”
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GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis by Amann, Thomas, Maegdefrau, Ulrike, Hartmann, Arndt, Agaimy, Abbas, Marienhagen, Jörg, Weiss, Thomas S, Stoeltzing, Oliver, Warnecke, Christina, Schölmerich, Jürgen, Oefner, Peter J, Kreutz, Marina, Bosserhoff, Anja K, Hellerbrand, Claus

“…Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 ( GLUT1 ) gene encodes a key rate-limiting…”
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LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid by Decking, Sonja-Maria, Bruss, Christina, Babl, Nathalie, Bittner, Sebastian, Klobuch, Sebastian, Thomas, Simone, Feuerer, Markus, Hoffmann, Petra, Dettmer, Katja, Oefner, Peter J, Renner, Kathrin, Kreutz, Marina

“…Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the tumor environment and determines the efficacy of adoptive T cell and…”
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Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry by Zhu, Wentao, Stevens, Axel P., Dettmer, Katja, Gottfried, Eva, Hoves, Sabine, Kreutz, Marina, Holler, Ernst, Canelas, André B., Kema, Ido, Oefner, Peter J.

“…A sensitive, selective, and comprehensive method for the quantitative determination of tryptophan and 18 of its key metabolites in serum, urine, and cell…”
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Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism by Cheng, Yurong, Schlosser, Pascal, Hertel, Johannes, Sekula, Peggy, Oefner, Peter J., Spiekerkoetter, Ute, Mielke, Johanna, Freitag, Daniel F., Schmidts, Miriam, Kronenberg, Florian, Eckardt, Kai-Uwe, Thiele, Ines, Li, Yong, Köttgen, Anna

“…Metabolite levels in urine may provide insights into genetic mechanisms shaping their related pathways. We therefore investigate the cumulative contribution of…”
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