Search Results - "Odom, Sandra"

The Sphingosine Kinase-Sphingosine-1-Phosphate Axis Is a Determinant of Mast Cell Function and Anaphylaxis by Olivera, Ana, Mizugishi, Kiyomi, Tikhonova, Anastassia, Ciaccia, Laura, Odom, Sandra, Proia, Richard L., Rivera, Juan

“…Sphingosine-1-phosphate, a key mediator in immune cell trafficking, is elevated in the lungs of asthmatic patients and regulates pulmonary epithelium…”
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Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation by Rivera, Juan, Parravicini, Valentino, Gadina, Massimo, Kovarova, Martina, Odom, Sandra, Gonzalez-Espinosa, Claudia, Furumoto, Yasuko, Saitoh, Shinichiroh, Samelson, Lawrence E, O'Shea, John J

“…Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for…”
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Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase by Odom, Sandra, Gomez, Gregorio, Kovarova, Martina, Furumoto, Yasuko, Ryan, John J, Wright, Harry V, Gonzalez-Espinosa, Claudia, Hibbs, Margaret L, Harder, Kenneth W, Rivera, Juan

“…A role for Lyn kinase as a positive regulator of immunoglobulin (Ig)E-dependent allergy has long been accepted. Contrary to this belief, Lyn kinase was found…”
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Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness by Kovarova, Martina, Wassif, Christopher A, Odom, Sandra, Liao, Katherine, Porter, Forbes D, Rivera, Juan

“…Mutation of the 3beta-hydroxysterol delta7-reductase gene (Dhcr7-/-) results in Smith-Lemli-Opitz syndrome (SLOS). Patients, and genetically altered mice, are…”
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Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells by Gonzalez-Espinosa, Claudia, Odom, Sandra, Olivera, Ana, Hobson, J Peyton, Martinez, Maria Eugenia Cid, Oliveira-Dos-Santos, Antonio, Barra, Lillian, Spiegel, Sarah, Penninger, Josef M, Rivera, Juan

“…Mast cell degranulation and de novo cytokine production is a consequence of antigen-aggregation of the immunoglobulin E (IgE)-occupied high affinity receptor…”
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CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction by Gri, Giorgia, Piconese, Silvia, Frossi, Barbara, Manfroi, Vanessa, Merluzzi, Sonia, Tripodo, Claudio, Viola, Antonella, Odom, Sandra, Rivera, Juan, Colombo, Mario P., Pucillo, Carlo E.

“…T regulatory (Treg) cells play a role in the suppression of immune responses, thus serving to induce tolerance and control autoimmunity. Here, we explored…”
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Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor by Furumoto, Yasuko, Gonzalez-Espinosa, Claudia, Gomez, Gregorio, Kovarova, Martina, Odom, Sandra, Parravicini, Valentino, Ryana, John J, Rivera, Juan

“…Antigen-induced cross-linking of immunoglobulin E (IgE) antibodies bound to the high-affinity IgE receptor (FcepsilonRI), on mast cells results in the release…”
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Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation by Alvarez-Errico, Damiana, Yamashita, Yumi, Suzuki, Ryo, Odom, Sandra, Furumoto, Yasuko, Yamashita, Toshiyuki, Rivera, Juan

“…Engagement of FcepsilonRI causes its phosphorylation by Lyn kinase. Two alternatively spliced variants, Lyn A and B, are expressed in mast cells, and both…”
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ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk by Moriya, Katsuhiro, Rivera, Juan, Odom, Sandra, Sakuma, Yoshinori, Muramato, Kenzo, Yoshiuchi, Tatsuya, Miyamoto, Mitsuaki, Yamada, Koji

“…Engagement of the mast cell high-affinity receptor for immunoglobulin E (IgE), FcɛRI, induces tyrosine phosphorylation of Syk, a non-receptor tyrosine kinase,…”
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Impaired FcεRI-Dependent Gene Expression and Defective Eicosanoid and Cytokine Production as a Consequence of Fyn Deficiency in Mast Cells by Gomez, Gregorio, Gonzalez-Espinosa, Claudia, Odom, Sandra, Baez, Gabriela, Cid, M. Eugenia, Ryan, John J., Rivera, Juan

“…Abstract Fyn kinase is a key contributor in coupling FcεRI to mast cell degranulation. A limited macroarray analysis of FcεRI-induced gene expression suggested…”
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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis by Falanga, Yves T, Chaimowitz, Natalia S, Charles, Nicolas, Finkelman, Fred D, Pullen, Nicholas A, Barbour, Suzanne, Dholaria, Kevin, Faber, Travis, Kolawole, Motunrayo, Huang, Bernice, Odom, Sandra, Rivera, Juan, Carlyon, Jason, Conrad, Daniel H, Spiegel, Sarah, Oskeritzian, Carole A, Ryan, John J

“…Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by…”
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Cutting Edge: Genetic Variation Influences FcεRI-Induced Mast Cell Activation and Allergic Responses by Yamashita, Yumi, Charles, Nicolas, Furumoto, Yasuko, Odom, Sandra, Yamashita, Toshiyuki, Gilfillan, Alasdair M., Constant, Stephanie, Bower, Molly A., Ryan, John J., Rivera, Juan

“…Abstract Mast cell responses are influenced by a diverse array of environmental factors, but little is known about the effect of genetic background. In this…”
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PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability by Furumoto, Yasuko, Charles, Nicolas, Olivera, Ana, Leung, Wai Hang, Dillahunt, Sandra, Sargent, Jennifer L., Tinsley, Kevin, Odom, Sandra, Scott, Eric, Wilson, Todd M., Ghoreschi, Kamran, Kneilling, Manfred, Chen, Mei, Lee, David M., Bolland, Silvia, Rivera, Juan

“…Kit regulation of mast cell proliferation and differentiation has been intimately linked to the activation of phosphatidylinositol 3-OH kinase (PI3K). The…”
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Opposing roles for fyn and lyn kinases in FcγR signaling and IgG-mediated systemic anaphylaxis (163.17) by Falanga, Yves, Finkelman, Fred, Odom, Sandra, Rivera, Juan, Oskeritzian, Carole, Ryan, John

“…Abstract Mast cells (MCs) are key players in the innate immune system and atopic diseases. Once activated, they degranulate and produce cytokines, resulting in…”
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Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice by Watford, Wendy T, Wang, Chun-Chi, Tsatsanis, Christos, Mielke, Lisa A, Eliopoulos, Aristides G, Daskalakis, Constantine, Charles, Nicolas, Odom, Sandra, Rivera, Juan, O'Shea, John, Tsichlis, Philip N

“…The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha. In…”
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The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation by Saitoh, Shin-ichiroh, Odom, Sandra, Gomez, Gregorio, Sommers, Connie L., Young, Howard A., Rivera, Juan, Samelson, Lawrence E.

“…The linker for activation of T cells (LAT) is an adaptor protein critical for FcεRI-mediated mast cell activation. LAT is a substrate of the tyrosine kinases…”
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Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor α-Subunit Expression in the Mammalian Pinealocyte: A NEUROENDOCRINE/IMMUNE RESPONSE LINK by Ganguly, Surajit, Grodzki, Cristina, Sugden, David, Møller, Morten, Odom, Sandra, Gaildrat, Pascaline, Gery, Igal, Siraganian, Reuben P, Rivera, Juan, Klein, David C

“…The high affinity immunoglobulin E receptor (FcεRI) complex is dedicated to immunoglobulin E-mediated allergic responses. Expression of the FcεRI receptor is…”
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IL-10 inhibits Fc epsilon RI expression in mouse mast cells by Gillespie, Sheila R, DeMartino, Randall R, Zhu, Jingfang, Chong, Hey Jin, Ramirez, Carlos, Shelburne, Christopher P, Bouton, L Andrew, Bailey, Daniel P, Gharse, Anita, Mirmonsef, Paria, Odom, Sandra, Gomez, Gregorio, Rivera, Juan, Fischer-Stenger, Krista, Ryan, John J

“…FcepsilonRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown…”
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CD4 super(+)CD25 super(+) Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction by Gri, Giorgia, Piconese, Silvia, Frossi, Barbara, Manfroi, Vanessa, Merluzzi, Sonia, Tripodo, Claudio, Viola, Antonella, Odom, Sandra, Rivera, Juan, Colombo, Mario P, Pucillo, Carlo E

“…T regulatory (Treg) cells play a role in the suppression of immune responses, thus serving to induce tolerance and control autoimmunity. Here, we explored…”
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Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production by Arcidiacono, Diletta, Odom, Sandra, Frossi, Barbara, Rivera, Juan, Paccani, Silvia R, Baldari, Cosima T, Pucillo, Carlo, Montecucco, Cesare, de Bernard, Marina

“…Many strains of Vibrio cholerae produce a cytolysin (VCC) that forms oligomeric transmembrane pores responsible for vacuolization of several cell types in…”
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