Search Results - "Odingo, Joshua"

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents by Kesicki, Edward A, Bailey, Mai A, Ovechkina, Yulia, Early, Julie V, Alling, Torey, Bowman, Julie, Zuniga, Edison S, Dalai, Suryakanta, Kumar, Naresh, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua O, Parish, Tanya

“…The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity…”
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Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target by Ollinger, Juliane, O'Malley, Theresa, Kesicki, Edward A, Odingo, Joshua, Parish, Tanya

“…Mycobacterium tuberculosis is a pathogen of major global importance. Validated drug targets are required in order to develop novel therapeutics for…”
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8‐Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis by Odingo, Joshua O., Early, Julie V., Smith, Jake, Johnson, James, Bailey, Mai A., Files, Megan, Guzman, Junitta, Ollinger, Juliane, Korkegian, Aaron, Kumar, Anuradha, Ovechkina, Yulia, Parish, Tanya

“…ABSTRACT There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8‐hydroxyquinoline…”
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Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity by Chandrasekera, N. Susantha, Alling, Torey, Bailey, Mai A, Files, Megan, Early, Julie V, Ollinger, Juliane, Ovechkina, Yulia, Masquelin, Thierry, Desai, Prashant V, Cramer, Jeffrey W, Hipskind, Philip A, Odingo, Joshua O, Parish, Tanya

“…We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the exemplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo­[d]­imidazole for its…”
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A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis by Kumar, Anuradha, Casey, Allen, Odingo, Joshua, Kesicki, Edward A, Abrahams, Garth, Vieth, Michal, Masquelin, Thierry, Mizrahi, Valerie, Hipskind, Philip A, Sherman, David R, Parish, Tanya

“…The enzyme pantothenate synthetase, PanC, is an attractive drug target in Mycobacterium tuberculosis. It is essential for the in vitro growth of M…”
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Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis by Bonnett, Shilah, Jee, Jo-Ann, Chettiar, Somsundaram, Ovechkina, Yulia, Korkegian, Aaron, Greve, Eric, Odingo, Joshua, Parish, Tanya

“…We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal…”
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Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth by Ray, Peter C, Huggett, Margaret, Turner, Penelope A, Taylor, Malcolm, Cleghorn, Laura A. T, Early, Julie, Kumar, Anuradha, Bonnett, Shilah A, Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L, Davis, Susan H, Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A, Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T, Lenaerts, Anne J, Freiberg, Gail, Kempf, Dale J, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua, Read, Kevin D, Green, Simon R, Wyatt, Paul G, Parish, Tanya

“…With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action…”
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Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis by Hembre, Erik, Early, Julie V, Odingo, Joshua, Shelton, Catherine, Anoshchenko, Olena, Guzman, Junitta, Flint, Lindsay, Dennison, Devon, McNeil, Matthew B, Korkegian, Aaron, Ovechkina, Yulia, Ornstein, Paul, Masquelin, Thierry, Hipskind, Philip A, Parish, Tanya

“…The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of…”
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In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis by Odingo, Joshua, Bailey, Mai A, Files, Megan, Early, Julie V, Alling, Torey, Dennison, Devon, Bowman, Julie, Dalai, Suryakanta, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A, Parish, Tanya

“…Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its…”
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Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis by Singh, Sheo B, Odingo, Joshua, Bailey, Mai A, Sunde, Bjorn, Korkegian, Aaron, O'Malley, Theresa, Ovechkina, Yulia, Ioerger, Thomas R, Sacchettini, James C, Young, Katherine, Olsen, David B, Parish, Tanya

“…Our aim was to identify natural products with anti-tubercular activity. A set of ~ 500 purified natural product compounds was screened for inhibition against…”
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Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides by Chandrasekera, N Susantha, Bailey, Mai A, Files, Megan, Alling, Torey, Florio, Stephanie K, Ollinger, Juliane, Odingo, Joshua O, Parish, Tanya

“…We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under…”
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Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB by Cleghorn, Laura A. T, Ray, Peter C, Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D, Green, Simon R, Hipskind, Phil, Parish, Tanya, Wyatt, Paul G

“…With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis there is a pressing need for new oral drugs with novel mechanisms of action…”
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The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents by Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya

“…[Display omitted] We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the…”
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Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential by Smith, Jake, Wescott, Heather, Early, Julie, Mullen, Steven, Guzman, Junitta, Odingo, Joshua, Lamar, Jason, Parish, Tanya

“…A family of compounds typified by an anthranilic amide was identified from a whole-cell screening effort targeted at identifying compounds that disrupt pH…”
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Anthranilic amide and imidazobenzothiadiazole compounds disrupt membrane potential by Smith, Jake, Wescott, Heather, Early, Julie, Mullen, Steven, Guzman, Junitta, Odingo, Joshua, Lamar, Jason, Parish, Tanya

“…A family of compounds typified by an anthranilic amide 1 was identified from a whole-cell screening effort targeted at identifying compounds that disrupt pH…”
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Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00088g by Smith, Jake, Wescott, Heather, Early, Julie, Mullen, Steven, Guzman, Junitta, Odingo, Joshua, Lamar, Jason, Parish, Tanya

“…Compounds 1 and 2 disrupt M. tuberculosis membrane potential and demonstrate bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer. A…”
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CD Exciton Chirality Method: Schiff Base and Cyanine Dye-Type Chromophores for Primary Amino Groups by Gargiulo, Dario, Ikemoto, Norihiro, Odingo, Joshua, Bozhkova, Nina, Iwashita, Takashi, Berova, Nina, Nakanishi, Koji

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Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB by Chandrasekera, N. Susantha, Berube, Bryan J, Shetye, Gauri, Chettiar, Somsundaram, O’Malley, Theresa, Manning, Alyssa, Flint, Lindsay, Awasthi, Divya, Ioerger, Thomas R, Sacchettini, James, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua, Parish, Tanya

“…The phenoxy alkyl benzimidazoles (PABs) have good antitubercular activity. We expanded our structure–activity relationship studies to determine the core…”
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Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis by Martinez-Grau, Maria Angeles, Valcarcel, Isabel C. Gonzalez, Early, Julie V., Gessner, Richard Klaus, de Melo, Candice Soares, de la Nava, Eva Maria Martin, Korkegian, Aaron, Ovechkina, Yulia, Flint, Lindsay, Gravelle, Anisa, Cramer, Jeff W., Desai, Prashant V., Street, Leslie J., Odingo, Joshua, Masquelin, Thierry, Chibale, Kelly, Parish, Tanya

“…[Display omitted] •We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis.•Improved compounds have…”
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Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents by Odingo, Joshua, O’Malley, Theresa, Kesicki, Edward A., Alling, Torey, Bailey, Mai Ann, Early, Julie, Ollinger, Juliane, Dalai, Suryakanta, Kumar, Naresh, Singh, Ravindra Vikram, Hipskind, Philip A., Cramer, Jeffrey W., Ioerger, Thomas, Sacchettini, James, Vickers, Richard, Parish, Tanya

“…[Display omitted] The 2,4-diaminoquinazoline class of compounds has previously been identified as an effective inhibitor of Mycobacterium tuberculosis growth…”
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