Search Results - "Odenkirk, Melanie T."

Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics by Odenkirk, Melanie T, Baker, Erin S

“…Metabolites and xenobiotics are small molecules with a molecular weight that often falls below 600 Da. Over the last few decades, multiple small molecule…”
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Contextualizing toxic elements in the diet: a case for integration of toxic element data into food databases by Jones, Rachel R, Odenkirk, Melanie T, Bertoldo, Jackie, Prenni, Jessica E

“…Food composition data plays a key role in the practice of nutrition. However, nutrition professionals may currently lack the resources they need to integrate…”
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Combining Micropunch Histology and Multidimensional Lipidomic Measurements for In-Depth Tissue Mapping by Odenkirk, Melanie T, Horman, Brian M, Dodds, James N, Patisaul, Heather B, Baker, Erin S

“…While decades of technical and analytical advancements have been utilized to discover novel lipid species, increase speciation, and evaluate localized lipid…”
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From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions by Odenkirk, Melanie T, Stratton, Kelly G, Bramer, Lisa M, Webb-Robertson, Bobbie-Jo M, Bloodsworth, Kent J, Monroe, Matthew E, Burnum-Johnson, Kristin E, Baker, Erin S

“…While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to…”
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Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments by Odenkirk, Melanie T, Reif, David M, Baker, Erin S

“…The need for holistic molecular measurements to better understand disease initiation, development, diagnosis, and therapy has led to an increasing number of…”
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Do Nanodisc Assembly Conditions Affect Natural Lipid Uptake? by Odenkirk, Melanie T., Zhang, Guozhi, Marty, Michael T.

“…Lipids play critical roles in modulating membrane protein structure, interactions, and activity. Nanodiscs provide a tunable membrane mimetic that can model…”
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Elucidating the role of lipid interactions in stabilizing the membrane protein KcsA by Qiao, Pei, Odenkirk, Melanie T, Zheng, Weiyi, Wang, Yuchen, Chen, Jinhui, Xu, Wenhao, Baker, Erin S

“…The significant effects of lipid binding on the functionality of potassium channel KcsA have been validated by brilliant studies. However, the specific…”
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Recent additions and access to a multidimensional lipidomic database containing liquid chromatography, ion mobility spectrometry, and tandem mass spectrometry information by Solosky, Amie M., Kirkwood-Donelson, Kaylie I., Odenkirk, Melanie T., Baker, Erin S.

“…The importance of lipids in biology continues to grow with their recent linkages to more diseases and conditions, microbiome fluctuations, and environmental…”
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Identifying Membrane Protein–Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry by Zhang, Guozhi, Odenkirk, Melanie T., Janczak, Colleen M., Lee, Ray, Richardson, Kevin, Wang, Zhihan, Aspinwall, Craig A., Marty, Michael T.

“…Lipids can play important roles in modulating membrane protein structure and function. However, it is challenging to identify natural lipids bound to membrane…”
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Combining native mass spectrometry and lipidomics to uncover specific membrane protein-lipid interactions from natural lipid sources by Zhu, Yun, Odenkirk, Melanie T, Qiao, Pei, Zhang, Tianqi, Schrecke, Samantha, Zhou, Ming, Marty, Michael T, Baker, Erin S, Laganowsky, Arthur

“…While it is known that lipids play an essential role in regulating membrane protein structure and function, it remains challenging to identify specific…”
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Cupric Ions Selectively Modulate TRAAK–Phosphatidylserine Interactions by Zhu, Yun, Schrecke, Samantha, Tang, Shuli, Odenkirk, Melanie T, Walker, Thomas, Stover, Lauren, Lyu, Jixing, Zhang, Tianqi, Russell, David, Baker, Erin S, Yan, Xin, Laganowsky, Arthur

“…TRAAK and TREK2 are two-pore domain K+ (K2P) channels and are modulated by diverse factors including temperature, membrane stretching, and lipids, such as…”
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Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems by Odenkirk, Melanie T, Zin, Phyo Phyo K, Ash, Jeremy R, Reif, David M, Fourches, Denis, Baker, Erin S

“…Since its inception, the main goal of the lipidomics field has been to characterize lipid species and their respective biological roles. However, difficulties…”
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Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions by Odenkirk, Melanie T., Zheng, Xueyun, Kyle, Jennifer E., Stratton, Kelly G., Nicora, Carrie D., Bloodsworth, Kent J., Mclean, Catriona A., Masters, Colin L., Monroe, Matthew E., Doecke, James D., Smith, Richard D., Burnum-Johnson, Kristin E., Roberts, Blaine R., Baker, Erin S.

“…Alzheimer’s disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and…”
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Impacts of Gestational FireMaster 550 Exposure on the Neonatal Cortex Are Sex Specific and Largely Attributable to the Organophosphate Esters by Witchey, Shannah K, Doyle, Michael G, Fredenburg, Jacob D, St Armour, Genevieve, Horman, Brian, Odenkirk, Melanie T, Aylor, David L, Baker, Erin S, Patisaul, Heather B

“…Flame retardants (FRs) are common bodily and environmental pollutants, creating concern about their potential toxicity. We and others have found that the…”
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Assessing the Fate of Dissolved Organic Compounds in Landfill Leachate and Wastewater Treatment Systems by Doyle, Michael G., Odenkirk, Melanie T., Stewart, Allison K., Nelson, Jacob P., Baker, Erin S., De La Cruz, Florentino

“…Landfill leachate and municipal wastewater are major sources of chemical pollutants that contaminate our drinking water sources. Evaluating the dissolved…”
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agCupric ions selectively modulate TRAAK-phosphatidylserine interactions by Zhu, Yun, Schrecke, Samantha, Tang, Shuli, Odenkirk, Melanie T., Walker, Thomas, Stover, Lauren, Lyu, Jixing, Zhang, Tianqi, Russell, David, Baker, Erin S., Yan, Xin, Laganowsky, Arthur

“…TRAAK and TREK2 are two-pore domain K + (K2P) channels and modulated by diverse factors including temperature, membrane stretching, and lipids, such as…”
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