Search Results - "Odell, Luke R"

Visible‐Light Photocatalysis as an Enabling Tool for the Functionalization of Unactivated C(sp3)‐Substrates by Roslin, Sara, Odell, Luke R.

“…Over the past decade, visible‐light photocatalysis has emerged as one of the brightest and most dynamic fields in modern organic chemistry. By employing a…”
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Synthesis of 4‑Quinolones via a Carbonylative Sonogashira Cross-Coupling Using Molybdenum Hexacarbonyl as a CO Source by Åkerbladh, Linda, Nordeman, Patrik, Wejdemar, Matyas, Odell, Luke R, Larhed, Mats

“…A palladium-catalyzed CO gas-free carbonylative Sonogashira/cyclization sequence for the preparation of functionalized 4-quinolones from 2-iodoanilines and…”
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Synthesis of N‑Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides by Chow, Shiao Y, Odell, Luke R

“…A Pd-catalyzed and ligand-free carbonylation/cycloaddition/decarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides…”
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Aminocarbonylations Employing Mo(CO)6 and a Bridged Two-Vial System: Allowing the Use of Nitro Group Substituted Aryl Iodides and Aryl Bromides by Nordeman, Patrik, Odell, Luke R, Larhed, Mats

“…A bridged two-vial system aminocarbonylation protocol where Mo­(CO)6 functions as an external in situ solid source of CO has been developed. For the first time…”
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Synthesis of 2‑Aminoquinazolinones via Carbonylative Coupling of ortho-Iodoanilines and Cyanamide by Åkerbladh, Linda, Odell, Luke R

“…Herein, we describe a convenient and efficient synthesis of 2-aminoquinazolin-4­(3H)-ones and N1-substituted 2-aminoquinazolin-4­(1H)-ones by a domino…”
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[ 18 F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44 by Cheung, Pierre, Amin, Mohammad A, Zhang, Bo, Lechi, Francesco, Korsgren, Olle, Eriksson, Jonas, Odell, Luke R, Eriksson, Olof

“…The progressive loss of beta-cell mass is a hallmark of diabetes and has been suggested as a complementary approach to studying the progression of diabetes in…”
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A microwave-assisted, propylphosphonic anhydride (T3P®) mediated one-pot Fischer indole synthesis by Desroses, Matthieu, Wieckowski, Krzysztof, Stevens, Marc, Odell, Luke R.

“…A rapid, mild, and high yielding protocol for the Fischer indolization of arylhydrazines with T3P® under microwave irradiation is described. Significant…”
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Inhibition of glutamine synthetase: a potential drug target in Mycobacterium tuberculosis by Mowbray, Sherry L, Kathiravan, Muthu K, Pandey, Abhishek A, Odell, Luke R

“…Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is…”
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Inhibition of Dynamin Mediated Endocytosis by the DynolesSynthesis and Functional Activity of a Family of Indoles by Hill, Timothy A, Gordon, Christopher P, McGeachie, Andrew B, Venn-Brown, Barbara, Odell, Luke R, Chau, Ngoc, Quan, Annie, Mariana, Anna, Sakoff, Jennette A, Chircop (nee Fabbro), Megan, Robinson, Phillip J, McCluskey, Adam

“…Screening identified two bisindolylmaleimides as 100 μM inhibitors of the GTPase activity of dynamin I. Focused library approaches allowed development of…”
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The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models by Odell, Luke R, Jones, Nigel C, Chau, Ngoc, Robertson, Mark J, Ambrus, Joseph I, Deane, Fiona M, Young, Kelly A, Whiting, Ainslie, Xue, Jing, Prichard, Kate, Daniel, James A, Gorgani, Nick N, O'Brien, Terence J, Robinson, Phillip J, McCluskey, Adam

“…We show that dansylcadaverine ( 1 ) a known in-cell inhibitor of clathrin mediated endocytosis (CME), moderately inhibits dynamin I (dynI) GTPase activity (IC…”
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Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA by Lechi, Francesco, Eriksson, Jonas, Odell, Luke R., Wegrzyniak, Olivia, Löfblom, John, Frejd, Fredrik Y., Zhang, Bo, Eriksson, Olof

“…Background In recent years, the interest in Al[ 18 F]F as a labeling agent for Positron Emission Tomography (PET) radiotracers has risen, as it allows for fast…”
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Aspartic protease inhibitors containing tertiary alcohol transition-state mimics by Motwani, Hitesh V., De Rosa, Maria, Odell, Luke R., Hallberg, Anders, Larhed, Mats

“…Aspartic proteases (APs) are a class of enzymes engaged in the proteolytic digestion of peptide substrates. APs play important roles in physiological and…”
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Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET by Schlein, Eva, Rokka, Johanna, Odell, Luke R., van den Broek, Sara Lopes, Herth, Matthias M., Battisti, Umberto M., Syvänen, Stina, Sehlin, Dag, Eriksson, Jonas

“…Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based…”
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Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates by Sävmarker, Jonas, Rydfjord, Jonas, Gising, Johan, Odell, Luke R, Larhed, Mats

“…A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was…”
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Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation by Roslin, Sara, Brandt, Peter, Nordeman, Patrik, Larhed, Mats, Odell, Luke, Eriksson, Jonas

“…Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes…”
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Microwave-Assisted aza-Friedel–Crafts Arylation of N‑Acyliminium Ions: Expedient Access to 4‑Aryl 3,4-Dihydroquinazolinones by Sawant, Rajiv T, Stevens, Marc Y, Odell, Luke R

“…A one-pot microwave-assisted aza-Friedel–Crafts arylation of N-acyliminium ions, generated in situ from o-formyl carbamates and different amines, is reported…”
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PET Imaging of GPR44 by Antagonist [ 11 C]MK-7246 in Pigs by Cheung, Pierre, Zhang, Bo, Puuvuori, Emmi, Estrada, Sergio, Amin, Mohammad A, Ye, Sofie, Korsgren, Olle, Odell, Luke R, Eriksson, Jonas, Eriksson, Olof

“…A validated imaging marker for beta-cell mass would improve understanding of diabetes etiology and enable new strategies in therapy development. We previously…”
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Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis by Hill, Timothy A, Mariana, Anna, Gordon, Christopher P, Odell, Luke R, Robertson, Mark J, McGeachie, Andrew B, Chau, Ngoc, Daniel, James A, Gorgani, Nick N, Robinson, Phillip J, McCluskey, Adam

“…Herein we report the synthesis of discrete iminochromene (“iminodyn”) libraries (14−38) as potential inhibitors of dynamin GTPase. Thirteen iminodyns were…”
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Synthesis of N‑Alkenylated Heterocycles via T3P‑Promoted Condensation with Ketones by Balestri, Lorenzo Jacopo Ilic, Beveridge, Julia, Gising, Johan, Odell, Luke R.

“…Herein, we describe a convenient protocol for the synthesis of N-alkenylated heterocycles using abundant ketone electrophiles and T3P as a water scavenger…”
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Synthesis of N -Alkenylated Heterocycles via T 3 P-Promoted Condensation with Ketones by Balestri, Lorenzo Jacopo Ilic, Beveridge, Julia, Gising, Johan, Odell, Luke R

“…Herein, we describe a convenient protocol for the synthesis of -alkenylated heterocycles using abundant ketone electrophiles and T P as a water scavenger under…”
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