Search Results - "Odde, David J."

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment by Bangasser, Benjamin L., Rosenfeld, Steven S., Odde, David J.

“…The mechanical stiffness of a cell’s environment exerts a strong, but variable, influence on cell behavior and fate. For example, different cell types cultured…”
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Traction Dynamics of Filopodia on Compliant Substrates by Chan, Clarence E, Odde, David J

“…Cells sense the environment's mechanical stiffness to control their own shape, migration, and fate. To better understand stiffness sensing, we constructed a…”
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Regulation of the MEX-5 Gradient by a Spatially Segregated Kinase/Phosphatase Cycle by Griffin, Erik E., Odde, David J., Seydoux, Geraldine

“…Protein concentration gradients encode spatial information across cells and tissues and often depend on spatially localized protein synthesis. Here, we report…”
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Evolving Tip Structures Can Explain Age-Dependent Microtubule Catastrophe by Coombes, Courtney E., Yamamoto, Ami, Kenzie, Madeline R., Odde, David J., Gardner, Melissa K.

“…Microtubules are key structural and transport elements in cells. The dynamics at microtubule ends are characterized by periods of slow growth, followed by…”
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Shifting the optimal stiffness for cell migration by Bangasser, Benjamin L., Shamsan, Ghaidan A., Chan, Clarence E., Opoku, Kwaku N., Tüzel, Erkan, Schlichtmann, Benjamin W., Kasim, Jesse A., Fuller, Benjamin J., McCullough, Brannon R., Rosenfeld, Steven S., Odde, David J.

“…Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many…”
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Rapid Microtubule Self-Assembly Kinetics by Gardner, Melissa K., Charlebois, Blake D., Jánosi, Imre M., Howard, Jonathon, Hunt, Alan J., Odde, David J.

“…Microtubule assembly is vital for many fundamental cellular processes. Current models for microtubule assembly kinetics assume that the subunit dissociation…”
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Estimating the Microtubule GTP Cap Size In Vivo by Seetapun, Dominique, Castle, Brian T., McIntyre, Alistair J., Tran, Phong T., Odde, David J.

“…Microtubules (MTs) polymerize via net addition of GTP-tubulin subunits to the MT plus end, which subsequently hydrolyze to GDP-tubulin in the MT lattice…”
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Cell Migration in 1D and 2D Nanofiber Microenvironments by Estabridis, Horacio M., Jana, Aniket, Nain, Amrinder, Odde, David J.

“…Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber…”
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Potential for Control of Signaling Pathways via Cell Size and Shape by Meyers, Jason, Craig, Jennifer, Odde, David J.

“…In order for signals generated at the plasma membrane to reach intracellular targets, activated messengers, such as G proteins and phosphoproteins, must…”
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Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model by Prahl, Louis S., Stanslaski, Maria R., Vargas, Pablo, Piel, Matthieu, Odde, David J.

“…Biological tissues contain micrometer-scale gaps and pores, including those found within extracellular matrix fiber networks, between tightly packed cells, and…”
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Mitosis, Diffusible Crosslinkers, and the Ideal Gas Law by Odde, David J.

“…During mitosis, molecular motors hydrolyze ATP to generate sliding forces between adjacent microtubules and form the bipolar mitotic spindle. Lansky et al. now…”
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Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends by Hendricks, Adam G., Lazarus, Jacob E., Perlson, Eran, Gardner, Melissa K., Odde, David J., Goldman, Yale E., Holzbaur, Erika L.F.

“…Microtubules undergo alternating periods of growth and shortening, known as dynamic instability. These dynamics allow microtubule plus ends to explore cellular…”
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Brownian Dynamics of Subunit Addition-Loss Kinetics and Thermodynamics in Linear Polymer Self-Assembly by Castle, Brian T., Odde, David J.

“…The structure and free energy of multistranded linear polymer ends evolves as individual subunits are added and lost. Thus, the energetic state of the polymer…”
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Minus-End-Directed Kinesin-14 Motors Align Antiparallel Microtubules to Control Metaphase Spindle Length by Hepperla, Austin J., Willey, Patrick T., Coombes, Courtney E., Schuster, Breanna M., Gerami-Nejad, Maryam, McClellan, Mark, Mukherjee, Soumya, Fox, Janet, Winey, Mark, Odde, David J., O’Toole, Eileen, Gardner, Melissa K.

“…During cell division, a microtubule-based mitotic spindle mediates the faithful segregation of duplicated chromosomes into daughter cells. Proper length…”
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RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes by Pawlak, Matthew R., Smiley, Adam T., Ramirez, Maria Paz, Kelly, Marcus D., Shamsan, Ghaidan A., Anderson, Sarah M., Smeester, Branden A., Largaespada, David A., Odde, David J., Gordon, Wendy R.

“…Mechanical forces drive critical cellular processes that are reflected in mechanical phenotypes, or mechanotypes, of cells and their microenvironment. We…”
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Monte Carlo simulations of microtubule arrays: The critical roles of rescue transitions, the cell boundary, and tubulin concentration in shaping microtubule distributions by Cassimeris, Lynne, Leung, Jessica C, Odde, David J

“…Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have…”
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Micropatterning of living cells by laser-guided direct writing: application to fabrication of hepatic-endothelial sinusoid-like structures by Odde, David J, Nahmias, Yaakov

“…Here, we describe a simple protocol for the design and construction of a laser-guided direct writing (LGDW) system able to micropattern the self-assembly of…”
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Mechanochemical Model of Microtubule Structure and Self-Assembly Kinetics by VanBuren, Vincent, Cassimeris, Lynne, Odde, David J.

“…Microtubule self-assembly is largely governed by the chemical kinetics and thermodynamics of tubulin-tubulin interactions. An important aspect of microtubule…”
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The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas by Ampudia-Mesias, Elisabet, Cameron, Charles S, Yoo, Eunjae, Kelly, Marcus, Anderson, Sarah M, Manning, Riley, Abrahante Lloréns, Juan E, Moertel, Christopher L, Yim, Hyungshin, Odde, David J, Saydam, Nurten, Saydam, Okay

“…Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite…”
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Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force by Bangasser, Benjamin L., Odde, David J.

“…Microenvironmental mechanics play an important role in determining the morphology, traction, migration, proliferation, and differentiation of cells. A…”
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