Search Results - "Odan, Masahide"

Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003 by Sasaki, Yoshikazu, Odan, Masahide, Yamamoto, Shiho, Kida, Shiro, Ueyama, Azumi, Shimizu, Masaya, Haruna, Takayo, Watanabe, Ayahisa, Okuno, Takayuki

“…[Display omitted] •Highly potent RORγt inhibitors discovered by a precise SAR study.•Detailed binding mode discussion of the compound guided by X-ray cocrystal…”
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Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported…”
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Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…The optimization of a series of 3-carbamoyl 2-pyridone derivatives as CB agonists is reported. These efforts resulted in the discovery of…”
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CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…Our lead compound 1 showed high affinity for both CB1 and CB2 receptors, suggesting the possibility of inducing psychoactive side effects through the CB1…”
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