Search Results - "Oda, Naoko"

A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab by Nakamura, Hitomi, Yoshikawa, Moeka, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi

“…Generally, intermolecular disulfide bond contribute to the conformational protein stability. To identify sites where intermolecular disulfide bond can be…”
Get full text

The habu genome reveals accelerated evolution of venom protein genes by Shibata, Hiroki, Chijiwa, Takahito, Oda-Ueda, Naoko, Nakamura, Hitomi, Yamaguchi, Kazuaki, Hattori, Shousaku, Matsubara, Kazumi, Matsuda, Yoichi, Yamashita, Akifumi, Isomoto, Akiko, Mori, Kazuki, Tashiro, Kosuke, Kuhara, Satoru, Yamasaki, Shinichi, Fujie, Manabu, Goto, Hiroki, Koyanagi, Ryo, Takeuchi, Takeshi, Fukumaki, Yasuyuki, Ohno, Motonori, Shoguchi, Eiichi, Hisata, Kanako, Satoh, Noriyuki, Ogawa, Tomohisa

“…Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein…”
Get full text

Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris by Nakamura, Hitomi, Kiyoshi, Masato, Anraku, Makoto, Hashii, Noritaka, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi

“…Glycoengineering of therapeutic proteins has been applied to improve the clinical efficacy of several therapeutics. Here, we examined the effect of…”
Get full text

SDS-induced oligomerization of Lys49-phospholipase A2 from snake venom by Matsui, Takashi, Kamata, Shizuka, Ishii, Kentaro, Maruno, Takahiro, Ghanem, Nouran, Uchiyama, Susumu, Kato, Koichi, Suzuki, Atsuo, Oda-Ueda, Naoko, Ogawa, Tomohisa, Tanaka, Yoshikazu

“…Phospholipase A 2 (PLA 2 ) is one of the representative toxic components of snake venom. PLA 2 s are categorized into several subgroups according to the amino…”
Get full text

Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake, Protobothrops flavoviridis by Ogawa, Tomohisa, Oda-Ueda, Naoko, Hisata, Kanako, Nakamura, Hitomi, Chijiwa, Takahito, Hattori, Shousaku, Isomoto, Akiko, Yugeta, Haruki, Yamasaki, Shinichi, Fukumaki, Yasuyuki, Ohno, Motonori, Satoh, Noriyuki, Shibata, Hiroki

“…Snake venoms are complex mixtures of toxic proteins encoded by various gene families that function synergistically to incapacitate prey. A huge repertoire of…”
Get full text

Dietary phosphate disturbs of gut microbiome in mice by Oda, Naoko, Sugihara, Kohei, Uebanso, Takashi, Ohminami, Hirokazu, Ohnishi, Kohta, Masuda, Masashi, Yamanaka-Okumura, Hisami, Taketani, Yutaka

“…Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates…”
Get full text

C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond by Nakamura, Hitomi, Anraku, Makoto, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi

“…Conjugation with polyethylene glycol (PEG) is performed to increase serum half-life of the Fab for clinical applications. However, current designs for…”
Get full text

Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab by Yoshikawa, Moeka, Nakamura, Hitomi, Oda-Ueda, Naoko, Ohkuri, Takatoshi

“…To identify amino acids that play important roles in the structural stability of Fab, seven phenylalanine residues in the Fab constant region of the…”
Get full text

Dietary phosphate exacerbates intestinal inflammation in experimental colitis by Sugihara, Kohei, Masuda, Masashi, Nakao, Mari, Abuduli, Maerjianghan, Imi, Yukiko, Oda, Naoko, Okahisa, Toshiya, Yamamoto, Hironori, Takeda, Eiji, Taketani, Yutaka

“…The recent widespread consumption of Western diets and food additives worldwide is associated with excessive inorganic phosphate intake. However, researchers…”
Get full text

Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab by Nakamura, Hitomi, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi

“…The production of therapeutic monoclonal antibodies is costly; therefore, antigen-binding fragments (Fabs) can be used instead. However, their tendency toward…”
Get full text

Two-Crystal Structures of Tropomyosin C-Terminal Fragment 176–273: Exposure of the Hydrophobic Core to the Solvent Destabilizes the Tropomyosin Molecule by Minakata, Shiho, Maeda, Kayo, Oda, Naoko, Wakabayashi, Katsuzo, Nitanai, Yasushi, Maéda, Yuichiro

“…Tropomyosin (Tm) is a two-stranded α-helical coiled-coil protein, and when associated with troponin, it is responsible for the actin filament-based regulation…”
Get full text

Altered Fecal Microbiotas and Organic Acid Concentrations Indicate Possible Gut Dysbiosis in University Rugby Players: An Observational Study by Morishima, So, Oda, Naoko, Ikeda, Hiromi, Segawa, Tomohiro, Oda, Machi, Tsukahara, Takamitsu, Kawase, Yasuharu, Takagi, Tomohisa, Naito, Yuji, Fujibayashi, Mami, Inoue, Ryo

“…Gut eubiosis is essential for the host's health. In athletes, the gut microbiota can be altered by several factors, including diets. While eubiotic gut…”
Get full text

Unique structure (construction and configuration) and evolution of the array of small serum protein genes of Protobothrops flavoviridis snake by Chijiwa, Takahito, Inamaru, Kento, Takeuchi, Ami, Maeda, Marie, Yamaguchi, Kazuaki, Shibata, Hiroki, Hattori, Shosaku, Oda-Ueda, Naoko, Ohno, Motonori

“…The nucleotide sequence of ( ) 30534 bp genome segment which contains genes encoding small serum proteins (SSPs) was deciphered. The genome segment contained…”
Get full text

Discovery of the Gene Encoding a Novel Small Serum Protein (SSP) of Protobothrops flavoviridis and the Evolution of SSPs by Inamaru, Kento, Takeuchi, Ami, Maeda, Marie, Shibata, Hiroki, Fukumaki, Yasuyuki, Oda-Ueda, Naoko, Hattori, Shosaku, Ohno, Motonori, Chijiwa, Takahito

“…Small serum proteins (SSPs) are low-molecular-weight proteins in snake serum with affinities for various venom proteins. Five SSPs, SSP-1 through SSP-5, have…”
Get full text

Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom by Ogawa, Tomohisa, Chijiwa, Takahito, Oda-Ueda, Naoko, Ohno, Motonori

“…A number of C-type lectin-like proteins that affect thrombosis and hemostasis by inhibiting or activating specific platelet membrane receptors or blood…”
Get full text

Modulation of Caenorhabditis elegans chemotaxis by cultivation and assay temperatures by Adachi, Ryota, Wakabayashi, Tokumitsu, Oda, Naoko, Shingai, Ryuzo

“…The chemotaxis behaviors of the nematode Caenorhabditis elegans cultivated at various temperatures (15 °C, 20 °C and 25 °C) were examined at various…”
Get full text

A [Lys49]phospholipase A2 from Protobothrops flavoviridis Venom Induces Caspase-Independent Apoptotic Cell Death Accompanied by Rapid Plasma-Membrane Rupture in Human Leukemia Cells by MURAKAMI, Tatsuo, KAMIKADO, Nobuyuki, FUJIMOTO, Ryo, HAMAGUCHI, Kazuhiko, NAKAMURA, Hitomi, CHIJIWA, Takahito, OHNO, Motonori, ODA-UEDA, Naoko

“…Protobothrops flavoviridis venom contains plural phospholipase A 2 (PLA 2 ) isozymes. A [Lys 49 ]PLA 2 called BPII induced cell death in human leukemia cells…”
Get full text

Interisland variegation of venom [Lys49]phospholipase A2 isozyme genes in Protobothrops genus snakes in the southwestern islands of Japan by Yamaguchi, Kazuaki, Chijiwa, Takahito, Yamamura, Takeshi, Ikeda, Naoki, Yatsui, Takayo, Hayama, Setsuko, Hattori, Shosaku, Oda-Ueda, Naoko, Ohno, Motonori

“…Protobothrops tokarensis (Pt), a Crotalinae snake, inhabits only Takarajima and Kodakarajima islands of the Tokara Islands located in the immediate north of…”
Get full text

Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity by Yoshikawa, Moeka, Nakamura, Hitomi, Oda-Ueda, Naoko, Ueda, Tadashi, Ohkuri, Takatoshi

“…Abstract The introduction of intermolecular disulfide bonds by amino acid mutations is an effective method for stabilizing dimeric proteins. X-ray crystal…”
Get full text

Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A2 isozyme genes by Nakamura, Hitomi, Murakami, Tatsuo, Hattori, Shosaku, Sakaki, Yoshiyuki, Ohkuri, Takatoshi, Chijiwa, Takahito, Ohno, Motonori, Oda-Ueda, Naoko

“…Protobothrops flavoviridis (habu) (Crotalinae, Viperidae) is a Japanese venomous snake, and its venom contains the enzymes with a variety of physiological…”
Get full text