Search Results - "Oda, Akihisa"

Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis by Kawai, Yasuhiro, Oda, Akihisa, Kanai, Yoshiakira, Goitsuka, Ryo

“…PKnox1 (also known as Prep1) belongs to the TALE family of homeodomain transcription factors that are critical for regulating growth and differentiation during…”
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Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1 by Oda, Akihisa, Tezuka, Toshiki, Ueno, Yuta, Hosoda, Shoko, Amemiya, Yusuke, Notsu, Chihiro, Kasahara, Toru, Nishiyama, Chiharu, Goitsuka, Ryo

“…Extramedullary hematopoiesis (EMH) in postnatal life is a pathological process in which the differentiation of hematopoietic stem/progenitor cells (HSPCs)…”
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Longitudinal profiling of anti-factor VIII antibodies in Japanese patients with congenital hemophilia A during factor VIII replacement and immune-tolerance induction therapy by Yoshimura, Takuji, Furukawa, Shoko, Oda, Akihisa, Matsumoto, Tomoko, Sasai, Kana, Shima, Midori, Nogami, Keiji

“…When patients with hemophilia A develop factor VIII (FVIII) inhibitors, FVIII replacement therapy becomes ineffective. Although immune-tolerance induction…”
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Angiopoietin-like 4 is a critical regulator of fibroblasts during pulmonary fibrosis development by Saito, Shoichiro, Kitabatake, Masahiro, Ouji-Sageshima, Noriko, Ogawa, Tatsuro, Oda, Akihisa, Nishimura, Tomoko, Nishioka, Tatsuki, Fushimi, Satoki, Hara, Atsushi, Shichino, Shigeyuki, Kumamoto, Makiko, Hontsu, Shigeto, Kawaguchi, Takeshi, Ueha, Satoshi, Sawabata, Noriyoshi, Muro, Shigeo, Matsushima, Kouji, Ito, Toshihiro

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial pneumonia caused by the excessive production and deposition of…”
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The spleen is the major site for the development and expansion of inhibitor producing-cells in hemophilia A mice upon FVIII infusion developing high-titer inhibitor by Oda, Akihisa, Furukawa, Shoko, Kitabatake, Masahiro, Ouji-sageshima, Noriko, Sonobe, Shota, Horiuchi, Kaoru, Nakajima, Yuto, Ogiwara, Kenichi, Goitsuka, Ryo, Shima, Midori, Ito, Toshihiro, Nogami, Keiji

“…Hemophilia A (HA) is a hereditary bleeding disorder caused by defects in endogenous factor (F)VIII. Approximately 30 % of patients with severe HA treated with…”
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Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen by Ueno, Yuta, Fujisaki, Keiko, Hosoda, Shoko, Amemiya, Yusuke, Okazaki, Shogo, Notsu, Chihiro, Nishiyama, Chiharu, Mabuchi, Yo, Matsuzaki, Yumi, Oda, Akihisa, Goitsuka, Ryo

“…The spleen is comprised of spatially distinct compartments whose functions, such as immune responses and removal of aged red blood cells, are tightly…”
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Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow by Yoshioka, Kentaro, Oda, Akihisa, Notsu, Chihiro, Ohtsuka, Takafumi, Kawai, Yasuhiro, Suzuki, Sadafumi, Nakamura, Takuro, Mabuchi, Yo, Matsuzaki, Yumi, Goitsuka, Ryo

“…Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused…”
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Generation of a Tlx1CreER-Venus knock-in mouse strain for the study of spleen development by Nakahara, Ryo, Kawai, Yasuhiro, Oda, Akihisa, Nishimura, Miyuki, Murakami, Akikazu, Azuma, Takachika, Kaifu, Tomonori, Goitsuka, Ryo

“…Summary The spleen is a lymphoid organ that serves as a unique niche for immune reactions, extramedullary hematopoiesis, and the removal of aged erythrocytes…”
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PKCη directs induction of IRF-4 expression and Ig κ gene rearrangement in pre-BCR signaling pathway by Oda, Akihisa, Ono, Tomohiro, Yamamoto, Mutsumi, Goitsuka, Ryo, Kitamura, Daisuke

“…Pre-B cell receptor (pre-BCR) signals promote pre-B cell differentiation, in which the adaptor protein B-cell linker (BLNK) plays a crucial role. However, the…”
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BLNK Binds Active H-Ras to Promote B Cell Receptor-mediated Capping and ERK Activation by Imamura, Yasuhiro, Oda, Akihisa, Katahira, Takashi, Bundo, Kenji, Pike, Kelly A., Ratcliffe, Michael J.H., Kitamura, Daisuke

“…Cross-linked B cell receptor (BCR) aggregates on the cell surface, then assembles into the “cap” where Ras is co-localized, and transduces various…”
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The emicizumab-bridged ternary complex with activated factor IX and factor X evaluated by fluorescence resonance energy transfer by Oda, Akihisa, Takeyama, Masahiro, Kitazawa, Takehisa, Nogami, Keiji

“…•Activated factor VIII (FVIIIa) functions as a cofactor for FIXa in the tenase complex.•Emicizumab is a humanized bispecific monoclonal antibody acts as a…”
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Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential by Nakajima, Yuto, Takeyama, Masahiro, Oda, Akihisa, Shimonishi, Naruto, Nogami, Keiji

“…•K1813 in the FVIII A3 domain, considered to be an FXa-binding site, is responsible for the A2 subunit dissociation of FVIIIa.•The FVIII-K1813A mutant showed…”
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The critical role of the histone modification enzyme Setdb2 in the pathogenesis of acute respiratory distress syndrome by Sonobe, Shota, Kitabatake, Masahiro, Hara, Atsushi, Konda, Makiko, Ouji-Sageshima, Noriko, Terada-Ikeda, Chiyoko, Furukawa, Ryutaro, Imakita, Natsuko, Oda, Akihisa, Takeda, Maiko, Takamura, Shiki, Inoue, Satoki, Kunkel, Steven L., Kawaguchi, Masahiko, Ito, Toshihiro

“…Introduction: Acute respiratory distress syndrome (ARDS) is a severe hypoxemic respiratory failure with a high in-hospital mortality. However, the molecular…”
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The combination of Asp519Val/Glu665Val and Lys1813Ala mutations in FVIII markedly increases coagulation potential by Nakajima, Yuto, Oda, Akihisa, Baatartsogt, Nemekhbayar, Kashiwakura, Yuji, Ohmori, Tsukasa, Nogami, Keiji

“…•The combined mutation of D519V/E665V and K1813A in FVIII increased FVIIIa stability and the association between FVIIIa and FIXa.•The FVIII-D519V/E665V/K1813A…”
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Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development by Nakahara, Ryo, Kawai, Yasuhiro, Oda, Akihisa, Nishimura, Miyuki, Murakami, Akikazu, Azuma, Takachika, Kaifu, Tomonori, Goitsuka, Ryo

“…The spleen is a lymphoid organ that serves as a unique niche for immune reactions, extramedullary hematopoiesis, and the removal of aged erythrocytes from the…”
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Generation of a T lx1 C re ER ‐ V enus knock‐in mouse strain for the study of spleen development by Nakahara, Ryo, Kawai, Yasuhiro, Oda, Akihisa, Nishimura, Miyuki, Murakami, Akikazu, Azuma, Takachika, Kaifu, Tomonori, Goitsuka, Ryo

“…Summary The spleen is a lymphoid organ that serves as a unique niche for immune reactions, extramedullary hematopoiesis, and the removal of aged erythrocytes…”
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Generation of a Tlx1 super(CreER-Venus) knock-in mouse strain for the study of spleen development by Nakahara, Ryo, Kawai, Yasuhiro, Oda, Akihisa, Nishimura, Miyuki, Murakami, Akikazu, Azuma, Takachika, Kaifu, Tomonori, Goitsuka, Ryo

“…The spleen is a lymphoid organ that serves as a unique niche for immune reactions, extramedullary hematopoiesis, and the removal of aged erythrocytes from the…”
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PKC[eta] directs induction of IRF-4 expression and Ig [kappa] gene rearrangement in pre-BCR signaling pathway by Oda, Akihisa, Ono, Tomohiro, Yamamoto, Mutsumi, Goitsuka, Ryo, Kitamura, Daisuke

“…Pre-B cell receptor (pre-BCR) signals promote pre-B cell differentiation, in which the adaptor protein B-cell linker (BLNK) plays a crucial role. However, the…”
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