Search Results - "Ocwieja, Karen E"

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency by Schaller, Torsten, Ocwieja, Karen E, Rasaiyaah, Jane, Price, Amanda J, Brady, Troy L, Roth, Shoshannah L, Hué, Stéphane, Fletcher, Adam J, Lee, KyeongEun, KewalRamani, Vineet N, Noursadeghi, Mahdad, Jenner, Richard G, James, Leo C, Bushman, Frederic D, Towers, Greg J

“…Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The…”
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HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 by Ocwieja, Karen E, Brady, Troy L, Ronen, Keshet, Huegel, Alyssa, Roth, Shoshannah L, Schaller, Torsten, James, Leo C, Towers, Greg J, Young, John A T, Chanda, Sumit K, König, Renate, Malani, Nirav, Berry, Charles C, Bushman, Frederic D

“…Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358…”
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Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing by Ocwieja, Karen E, Sherrill-Mix, Scott, Mukherjee, Rithun, Custers-Allen, Rebecca, David, Patricia, Brown, Michael, Wang, Susana, Link, Darren R, Olson, Jeff, Travers, Kevin, Schadt, Eric, Bushman, Frederic D

“…Alternative RNA splicing greatly expands the repertoire of proteins encoded by genomes. Next-generation sequencing (NGS) is attractive for studying alternative…”
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Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction by Jeong, Minjin, Ocwieja, Karen E., Han, Dongjun, Wackym, P. Ashley, Zhang, Yichen, Brown, Alyssa, Moncada, Cynthia, Vambutas, Andrea, Kanne, Theodore, Crain, Rachel, Siegel, Noah, Leger, Valerie, Santos, Felipe, Welling, D. Bradley, Gehrke, Lee, Stankovic, Konstantina M.

“…Background COVID-19 is a pandemic respiratory and vascular disease caused by SARS-CoV-2 virus. There is a growing number of sensory deficits associated with…”
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A reverse transcription loop-mediated isothermal amplification assay optimized to detect multiple HIV subtypes by Ocwieja, Karen E, Sherrill-Mix, Scott, Liu, Changchun, Song, Jinzhao, Bau, Haim, Bushman, Frederic D

“…Diagnostic methods for detecting and quantifying HIV RNA have been improving, but efficient methods for point-of-care analysis are still needed, particularly…”
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HIV latency and integration site placement in five cell-based models by Sherrill-Mix, Scott, Lewinski, Mary K, Famiglietti, Marylinda, Bosque, Alberto, Malani, Nirav, Ocwieja, Karen E, Berry, Charles C, Looney, David, Shan, Liang, Agosto, Luis M, Pace, Matthew J, Siliciano, Robert F, O'Doherty, Una, Guatelli, John, Planelles, Vicente, Bushman, Frederic D

“…HIV infection can be treated effectively with antiretroviral agents, but the persistence of a latent reservoir of integrated proviruses prevents eradication of…”
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A Call for Pediatric COVID-19 Clinical Trials by Campbell, Jeffrey I, Ocwieja, Karen E, Nakamura, Mari M

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Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats by Sherrill-Mix, Scott, Ocwieja, Karen E, Bushman, Frederic D

“…HIV infection has been reported to alter cellular gene activity, but published studies have commonly assayed transformed cell lines and lab-adapted HIV…”
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Comparing DNA integration site clusters with scan statistics by Berry, Charles C, Ocwieja, Karen E, Malani, Nirav, Bushman, Frederic D

“…Gene therapy with retroviral vectors can induce adverse effects when those vectors integrate in sensitive genomic regions. Retroviral vectors are preferred…”
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Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient by Lippa, Andrew M., Ocwieja, Karen E., Iglesias, Julie, Fawaz, Rima, Elisofon, Scott, Lee, Christine, Sharma, Tanvi S.

“…A 20‐year‐old male presented 3.5 years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was…”
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Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting by Gijsbers, Rik, Vets, Sofie, De Rijck, Jan, Ocwieja, Karen E, Ronen, Keshet, Malani, Nirav, Bushman, Frederic D, Debyser, Zeger

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Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting by Gijsbers, Rik, Vets, Sofie, De Rijck, Jan, Ocwieja, Karen E., Ronen, Keshet, Malani, Nirav, Bushman, Frederic D., Debyser, Zeger

“…LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral integration site preference. In this study we determined the…”
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The Effect of Play Type and Collision Closing Distance on Head Impact Biomechanics by Ocwieja, Karen E., Mihalik, Jason P., Marshall, Stephen W., Schmidt, Julianne D., Trulock, Scott C., Guskiewicz, Kevin M.

“…Football accounts for 55% of concussions to collegiate athletes. In the National Football League, players are at a greater risk for concussion during kickoffs…”
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Pediatric post‐transplant hepatic kaposi sarcoma due to donor‐derived human herpesvirus 8 by Ocwieja, Karen E., Vargas, Sara O., Elisofon, Scott A., Shulman, David S., Lee, Christine K., Fawaz, Rima, Collins, Natalie, Vakili, Khashayar, Sharma, Tanvi S.

“…In areas of the world where human herpesvirus 8 (HHV‐8) is endemic, Kaposi sarcoma (KS) is a common SOT‐associated cancer. In the United States, where the…”
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Phylogeography and molecular epidemiology of an epidemic strain of dengue virus type 1 in Sri Lanka by Ocwieja, Karen E, Fernando, Anira N, Sherrill-Mix, Scott, Sundararaman, Sesh A, Tennekoon, Rashika N, Tippalagama, Rashmi, Krishnananthasivam, Shivankari, Premawansa, Gayani, Premawansa, Sunil, De Silva, Aruna Dharshan

“…In 2009, a severe epidemic of dengue disease occurred in Sri Lanka, with higher mortality and morbidity than any previously recorded epidemic in the country…”
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Metal Cofactors in the Structure and Activity of the Fowlpox Resolvase by Culyba, Matthew J., Hwang, Young, Hu, Jimmy Yan, Minkah, Nana, Ocwieja, Karen E., Bushman, Frederic D.

“…Poxvirus DNA replication generates linear concatemers containing many copies of the viral genome with inverted repeat sequences at the junctions between…”
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Withdrawal: Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting by Gijsbers, Rik, Vets, Sofie, De Rijck, Jan, Ocwieja, Karen E., Ronen, Keshet, Malani, Nirav, Bushman, Frederic D., Debyser, Zeger

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A Reverse Transcription Loop-Mediated Isothermal Amplification Assay Optimized to Detect Multiple HIV Subtypes: e0117852 by Ocwieja, Karen E, Sherrill-Mix, Scott, Liu, Changchun, Song, Jinzhao, Bau, Haim, Bushman, Frederic D

“…Diagnostic methods for detecting and quantifying HIV RNA have been improving, but efficient methods for point-of-care analysis are still needed, particularly…”
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Patterns of HIV integration and splicing: Windows on mechanism by Ocwieja, Karen E

“…The retrovirus HIV-1 establishes lifelong infections, facilitated by integration, the covalent insertion of the viral cDNA into the host cell genome. After…”
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Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8 by Ocwieja, Karen E, Vargas, Sara O, Elisofon, Scott A, Shulman, David S, Lee, Christine K, Fawaz, Rima, Collins, Natalie, Vakili, Khashayar, Sharma, Tanvi S

“…In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the…”
Get full text