Search Results - "Ockinger, Johan"

Critical role for calcium mobilization in activation of the NLRP3 inflammasome by Murakami, Tomohiko, Ockinger, Johan, Yu, Jiujiu, Byles, Vanessa, McColl, Aisleen, Hofer, Aldebaran M, Horng, Tiffany

“…The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates production of inflammatory…”
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The lung microbiota in early rheumatoid arthritis and autoimmunity by Scher, Jose U, Joshua, Vijay, Artacho, Alejandro, Abdollahi-Roodsaz, Shahla, Öckinger, Johan, Kullberg, Susanna, Sköld, Magnus, Eklund, Anders, Grunewald, Johan, Clemente, Jose C, Ubeda, Carles, Segal, Leopoldo N, Catrina, Anca I

“…Airway abnormalities and lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This…”
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Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking by Ringh, Mikael V, Hagemann-Jensen, Michael, Needhamsen, Maria, Kullberg, Susanna, Wahlström, Jan, Grunewald, Johan, Brynedal, Boel, Jagodic, Maja, Ekström, Tomas J, Öckinger, Johan, Kular, Lara

“…Background: Despite compelling evidence that cigarette smoking impacts the risk of developing multiple sclerosis (MS), little is known about smoking-associated…”
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Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals by Berg, Tove, Hegelund-Myrbäck, Tove, Öckinger, Johan, Zhou, Xiao-Hong, Brännström, Marie, Hagemann-Jensen, Michael, Werkström, Viktoria, Seidegård, Janeric, Grunewald, Johan, Nord, Magnus, Gustavsson, Lena

“…Several inhaled drugs are dependent on organic cation transporters to cross cell membranes. To further evaluate their potential to impact on inhaled drug…”
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Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats by Adzemovic, Milena Z, Öckinger, Johan, Zeitelhofer, Manuel, Hochmeister, Sonja, Beyeen, Amennai Daniel, Paulson, Atul, Gillett, Alan, Thessen Hedreul, Melanie, Covacu, Ruxandra, Lassmann, Hans, Olsson, Tomas, Jagodic, Maja

“…Multiple sclerosis (MS) is a polygenic disease characterized by inflammation and demyelination in the central nervous system (CNS), which can be modeled in…”
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Distinctive Regulatory T Cells and Altered Cytokine Profile Locally in the Airways of Young Smokers with Normal Lung Function by Ostadkarampour, Mahyar, Müller, Malin, Öckinger, Johan, Kullberg, Susanna, Lindén, Anders, Eklund, Anders, Grunewald, Johan, Wahlström, Jan

“…Smoking influences the immune system in different ways and, hypothetically, effects on pulmonary effector and regulatory T cells emerge as potentially…”
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Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells by Ringh, Mikael V., Hagemann-Jensen, Michael, Needhamsen, Maria, Kular, Lara, Breeze, Charles E., Sjöholm, Louise K., Slavec, Lara, Kullberg, Susanna, Wahlström, Jan, Grunewald, Johan, Brynedal, Boel, Liu, Yun, Almgren, Malin, Jagodic, Maja, Öckinger, Johan, Ekström, Tomas J.

“…While smoking is known to associate with development of multiple diseases, the underlying mechanisms are still poorly understood. Tobacco smoking can modify…”
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T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis by Öckinger, Johan, Hagemann-Jensen, Michael, Kullberg, Susanna, Engvall, Benita, Eklund, Anders, Grunewald, Johan, Piehl, Fredrik, Olsson, Tomas, Wahlström, Jan

“…Abstract Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15 + smokers. To define the…”
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Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene by Stridh, Pernilla, Ruhrmann, Sabrina, Bergman, Petra, Thessén Hedreul, Mélanie, Flytzani, Sevasti, Beyeen, Amennai Daniel, Gillett, Alan, Krivosija, Nina, Öckinger, Johan, Ferguson-Smith, Anne C, Jagodic, Maja

“…Parent-of-origin effects comprise a range of genetic and epigenetic mechanisms of inheritance. Recently, detection of such effects implicated epigenetic…”
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Hospital diagnosed pneumonia before age 20 years and multiple sclerosis risk by Smith, Kelsi A, Hiyoshi, Ayako, Burkill, Sarah, Bahmanyar, Shahram, Öckinger, Johan, Alfredsson, Lars, Olsson, Tomas, Montgomery, Scott

“…IntroductionRespiratory inflammation has been proposed as a risk factor for MS. This study aims to determine if hospital-diagnosed pneumonia in adolescence…”
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IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation by Beyeen, Amennai D, Adzemovic, Milena Z, Ockinger, Johan, Stridh, Pernilla, Becanovic, Kristina, Laaksonen, Hannes, Lassmann, Hans, Harris, Robert A, Hillert, Jan, Alfredsson, Lars, Celius, Elisabeth G, Harbo, Hanne F, Kockum, Ingrid, Jagodic, Maja, Olsson, Tomas

“…Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the CNS. Recent advances in whole-genome screening tools have enabled discovery of…”
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Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat by Stridh, Pernilla, Thessen Hedreul, Melanie, Beyeen, Amennai Daniel, Adzemovic, Milena Z, Laaksonen, Hannes, Gillett, Alan, Ockinger, Johan, Marta, Monica, Lassmann, Hans, Becanovic, Kristina, Jagodic, Maja, Olsson, Tomas

“…To elucidate mechanisms involved in multiple sclerosis (MS), we studied genetic regulation of experimental autoimmune encephalomyelitis (EAE) in rats, assuming…”
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A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock by Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blázquez, Gloria, Martinez-Membrives, Esther, Cañete, Toni, Vicens-Costa, Elia, Graham, Delyth, Copley, Richard R, Hernandez-Pliego, Polinka, Beyeen, Amennai D, Ockinger, Johan, Fernández-Santamaría, Cristina, Gulko, Percio S, Brenner, Max, Tobeña, Adolf, Guitart-Masip, Marc, Giménez-Llort, Lydia, Dominiczak, Anna, Holmdahl, Rikard, Gauguier, Dominique, Olsson, Tomas, Mott, Richard, Valdar, William, Redei, Eva E, Fernández-Teruel, Alberto, Flint, Jonathan

“…The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated…”
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Advanced Intercross Line Mapping Suggests That Ncf1 (Ean6) Regulates Severity in an Animal Model of Guillain-Barre Syndrome by Huberle, Alexander, Beyeen, Amennai Daniel, Ockinger, Johan, Ayturan, Miriam, Jagodic, Maja, de Graaf, Katrien L, Fissolo, Nicolas, Marta, Monica, Olofsson, Peter, Hultqvist, Malin, Holmdahl, Rikard, Olsson, Tomas, Weissert, Robert

“…We here present the first genetic fine mapping of experimental autoimmune neuritis (EAN), the animal model of Guillain-Barré syndrome, in a rat advanced…”
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Vra4 Congenic Rats with Allelic Differences in the Class II Transactivator Gene Display Altered Susceptibility to Experimental Autoimmune Encephalomyelitis by Harnesk, Karin, Swanberg, Maria, Ockinger, Johan, Diez, Margarita, Lidman, Olle, Wallstrom, Erik, Lobell, Anna, Olsson, Tomas, Piehl, Fredrik

“…Presentation of Ag bound to MHC class II (MHC II) molecules to CD4+ T cells is a key event in adaptive immune responses. Genetic differences in MHC II…”
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Combined sequence-based and genetic mapping analysis of complex traits in outbred rats by Baud, Amelie, Hermsen, Roel, Guryev, Victor, Stridh, Pernilla, Graham, Delyth, McBride, Martin W, Foroud, Tatiana, Calderari, Sophie, Diez, Margarita, Ockinger, Johan, Beyeen, Amennai D, Gillett, Alan, Abdelmagid, Nada, Guerreiro-Cacais, Andre Ortlieb, Jagodic, Maja, Tuncel, Jonatan, Norin, Ulrika, Beattie, Elisabeth, Huynh, Ngan, Miller, William H, Koller, Daniel L, Alam, Imranul, Falak, Samreen, Osborne-Pellegrin, Mary, Martinez-Membrives, Esther, Canete, Toni, Blazquez, Gloria, Vicens-Costa, Elia, Mont-Cardona, Carme, Diaz-Moran, Sira, Tobena, Adolf, Hummel, Oliver, Zelenika, Diana, Saar, Kathrin, Patone, Giannino, Bauerfeind, Anja, Bihoreau, Marie-Therese, Heinig, Matthias, Lee, Young-Ae, Rintisch, Carola, Schulz, Herbert, Wheeler, David A, Worley, Kim C, Muzny, Donna M, Gibbs, Richard A, Lathrop, Mark, Lansu, Nico, Toonen, Pim, Ruzius, Frans Paul, de Bruijn, Ewart, Hauser, Heidi, Adams, David J, Keane, Thomas, Atanur, Santosh S, Aitman, Tim J, Flicek, Paul, Malinauskas, Tomas, Jones, E Yvonne, Ekman, Diana, Lopez-Aumatell, Regina, Dominiczak, Anna F, Johannesson, Martina, Holmdahl, Rikard, Olsson, Tomas, Gauguier, Dominique, Hubner, Norbert, Fernandez-Teruel, Alberto, Cuppen, Edwin, Mott, Richard, Flint, Jonathan

“…The Rat Genome Sequencing and Mapping Consortium reports a combined sequence-based and genetic mapping analysis of 160 phenotypes in an outbred rat…”
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Meta-analysis of the clinical performance of commercial SARS-CoV-2 nucleic acid and antibody tests up to 22 August 2020 by Van Walle, Ivo, Leitmeyer, Katrin, Broberg, Eeva K

“…BackgroundReliable testing for SARS-CoV-2 is key for the management of the COVID-19 pandemic.AimWe estimate diagnostic accuracy for nucleic acid and antibody…”
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Definition of a 1.06-Mb Region Linked to Neuroinflammation in Humans, Rats and Mice by Ockinger, Johan, Serrano-Fernandez, Pablo, Moller, Steffen, Ibrahim, Saleh M, Olsson, Tomas, Jagodic, Maja

“…Unbiased identification of susceptibility genes might provide new insights into pathogenic mechanisms that govern complex inflammatory diseases such as…”
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Genomes and phenomes of a population of outbred rats and its progenitors by Baud, Amelie, Guryev, Victor, Hummel, Oliver, Johannesson, Martina, Flint, Jonathan

“…Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats…”
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Genomes and phenomes of a population of outbred rats and its progenitors by Baud, Amelie, Guryev, Victor, Hummel, Oliver, Johannesson, Martina, Flint, Jonathan

“…This corrects the article DOI: 10.1038/sdata.2014.11…”
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