Search Results - "Ochsenbein, Adrian"

Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells by Schürch, Christian M., Riether, Carsten, Ochsenbein, Adrian F.

“…Cytotoxic CD8+ T cells (CTLs) play a major role in host defense against intracellular pathogens, but a complete clearance of pathogens and return to…”
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Genetic Alterations Impact Immune Microenvironment Interactions in Follicular Lymphoma by Riether, Carsten, Ochsenbein, Adrian F.

“…Interactions between germinal center B cells and immune cells in the microenvironment can play integral roles in transformation and growth of follicular…”
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Programmed death 1 signaling on chronic myeloid leukemia–specific T cells results in T-cell exhaustion and disease progression by Mumprecht, Sabine, Schürch, Christian, Schwaller, Juerg, Solenthaler, Max, Ochsenbein, Adrian F.

“…Chronic myeloid leukemia (CML) is a malignant myeloproliferative disease with a characteristic chronic phase (cp) of several years before progression to blast…”
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IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion by Radpour, Ramin, Simillion, Cedric, Wang, Bofei, Abbas, Hussein A., Riether, Carsten, Ochsenbein, Adrian F.

“…•IL-9 secreted by AML LSCs epigenetically activates CD4+ T cells and induces Th1 skewing.•IFN-γ and TNF-α produced by activated CD4+ T cells expand LSCs…”
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SAKK 16/14: Durvalumab in Addition to Neoadjuvant Chemotherapy in Patients With Stage IIIA(N2) Non–Small-Cell Lung Cancer—A Multicenter Single-Arm Phase II Trial by Rothschild, Sacha I., Zippelius, Alfred, Eboulet, Eric I., Savic Prince, Spasenija, Betticher, Daniel, Bettini, Adrienne, Früh, Martin, Joerger, Markus, Lardinois, Didier, Gelpke, Hans, Mauti, Laetitia A., Britschgi, Christian, Weder, Walter, Peters, Solange, Mark, Michael, Cathomas, Richard, Ochsenbein, Adrian F., Janthur, Wolf-Dieter, Waibel, Christine, Mach, Nicolas, Froesch, Patrizia, Buess, Martin, Bohanes, Pierre, Godar, Gilles, Rusterholz, Corinne, Gonzalez, Michel, Pless, Miklos

“…PURPOSE For patients with resectable stage IIIA(N2) non–small-cell lung cancer, neoadjuvant chemotherapy with cisplatin and docetaxel followed by surgery…”
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Molecular and immunological mechanisms of clonal evolution in multiple myeloma by Forster, Stefan, Radpour, Ramin, Ochsenbein, Adrian F.

“…Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells in the bone marrow (BM). It is known that early…”
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CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia by Riether, Carsten, Schürch, Christian M, Bührer, Elias D, Hinterbrandner, Magdalena, Huguenin, Anne-Laure, Hoepner, Sabine, Zlobec, Inti, Pabst, Thomas, Radpour, Ramin, Ochsenbein, Adrian F

“…Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiation of malignant blasts are key oncogenic drivers in acute…”
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Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling by Balmer, Maria L, Schürch, Christian M, Saito, Yasuyuki, Geuking, Markus B, Li, Hai, Cuenca, Miguelangel, Kovtonyuk, Larisa V, McCoy, Kathy D, Hapfelmeier, Siegfried, Ochsenbein, Adrian F, Manz, Markus G, Slack, Emma, Macpherson, Andrew J

“…Neutropenia is probably the strongest known predisposition to infection with otherwise harmless environmental or microbiota-derived species. Because initial…”
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Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents by Riether, Carsten, Pabst, Thomas, Höpner, Sabine, Bacher, Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid H., Francisco, David, Bruggmann, Remy, van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, de Haard, Hans, Leupin, Nicolas, Ochsenbein, Adrian F.

“…Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist conventional chemotherapy and are the major cause of relapse 1 , 2 …”
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TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis by Zysset, Daniel, Weber, Benjamin, Rihs, Silvia, Brasseit, Jennifer, Freigang, Stefan, Riether, Carsten, Banz, Yara, Cerwenka, Adelheid, Simillion, Cedric, Marques-Vidal, Pedro, Ochsenbein, Adrian F., Saurer, Leslie, Mueller, Christoph

“…Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses, but its significance in…”
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T-cell-Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer by Al Sayed, Mohamad F, Amrein, Michael A, Bührer, Elias D, Huguenin, Anne-Laure, Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F

“…: Hematopoiesis in patients with cancer is characterized by reduced production of red blood cells and an increase in myelopoiesis, which contributes to the…”
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CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth by CLAUS, Christina, RIETHER, Carsten, SCHÜRCH, Christian, MATTER, Matthias S, HILMENYUK, Tamara, OCHSENBEIN, Adrian F

“…Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways to elicit T- and B-cell responses. CD27 signaling is regulated by the…”
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Induction chemoradiation in stage IIIA/N2 non-small-cell lung cancer: a phase 3 randomised trial by Pless, Miklos, Dr, Stupp, Roger, Prof, Ris, Hans-Beat, Prof, Stahel, Rolf A, Prof, Weder, Walter, Prof, Thierstein, Sandra, Gerard, Marie-Aline, PhD, Xyrafas, Alexandros, Früh, Martin, MD, Cathomas, Richard, MD, Zippelius, Alfred, MD, Roth, Arnaud, MD, Bijelovic, Milorad, MD, Ochsenbein, Adrian, Prof, Meier, Urs R, MD, Mamot, Christoph, MD, Rauch, Daniel, MD, Gautschi, Oliver, MD, Betticher, Daniel C, MD, Mirimanoff, René-Olivier, Prof, Peters, Solange, MD

“…Summary Background One of the standard options in the treatment of stage IIIA/N2 non-small-cell lung cancer is neoadjuvant chemotherapy and surgery. We did a…”
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Epigenetic Silencing of Immune-Checkpoint Receptors in Bone Marrow- Infiltrating T Cells in Acute Myeloid Leukemia by Radpour, Ramin, Stucki, Miriam, Riether, Carsten, Ochsenbein, Adrian F

“…Immune-checkpoint (IC) inhibitors have revolutionized the treatment of multiple solid tumors and defined lymphomas, but they are largely ineffective in acute…”
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CD8+ T cells expand stem and progenitor cells in favorable but not adverse risk acute myeloid leukemia by Radpour, Ramin, Riether, Carsten, Simillion, Cedric, Höpner, Sabine, Bruggmann, Rémy, Ochsenbein, Adrian F.

“…CD8 + T cell immunosurveillance is crucial in solid tumors and T cell dysfunction leads to tumor progression. In contrast, the role of CD8 + T cells in the…”
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Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma by STUPP, Roger, HEGI, Monika E, PIETSCH, Torsten, HICKING, Christine, TONN, Joerg-Christian, DISERENS, Annie-Claire, PICA, Alessia, HERMISSON, Mirjam, KRUEGER, Stefan, PICARD, Martin, WELLER, Michael, NEYNS, Bart, GOLDBRUNNER, Roland, SCHLEGEL, Uwe, CLEMENT, Paul M. J, GRABENBAUER, Gerhard G, OCHSENBEIN, Adrian F, SIMON, Matthias, DIETRICH, Pierre-Yves

“…Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence. Integrin inhibition using cilengitide has shown synergy…”
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Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ by Schürch, Christian, Riether, Carsten, Amrein, Michael A, Ochsenbein, Adrian F

“…Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the oncogenic break point cluster region/Abelson murine leukemia viral…”
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Results from a phase I/II trial of cusatuzumab combined with azacitidine in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive chemotherapy by Pabst, Thomas, Vey, Norbert, Adès, Lionel, Bacher, Ulrike, Bargetzi, Mario, Fung, Samson, Gaidano, Gianluca, Gandini, Domenica, Hultberg, Anna, Johnson, Amy, Ma, Xuewen, Müller, Rouven, Nottage, Kerri, Papayannidis, Cristina, Recher, Christian, Riether, Carsten, Shah, Priya, Tryon, Jeffrey, Xiu, Liang, Ochsenbein, Adrian F

“…Cusatuzumab is a high-affinity, anti-CD70 monoclonal antibody under investigation in acute myeloid leukemia (AML). This two-part, open-label, multicenter,…”
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Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling by Riether, Carsten, Schürch, Christian M, Flury, Christoph, Hinterbrandner, Magdalena, Drück, Linda, Huguenin, Anne-Laure, Baerlocher, Gabriela M, Radpour, Ramin, Ochsenbein, Adrian F

“…In chronic myelogenous leukemia (CML), oncogenic BCR-ABL1 activates the Wnt pathway, which is fundamental for leukemia stem cell (LSC) maintenance. Tyrosine…”
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mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer by Liang, Shun-Qing, Bührer, Elias D., Berezowska, Sabina, Marti, Thomas M., Xu, Duo, Froment, Laurène, Yang, Haitang, Hall, Sean R. R., Vassella, Erik, Yang, Zhang, Kocher, Gregor J., Amrein, Michael A., Riether, Carsten, Ochsenbein, Adrian F., Schmid, Ralph A., Peng, Ren-Wang

“…Oncogenic KRAS mutations comprise the largest subset of lung cancer defined by genetic alterations, but in the clinic no targeted therapies are available that…”
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