Search Results - "Ochodnický, Peter"

Nerve growth factor in bladder dysfunction: Contributing factor, biomarker, and therapeutic target by Ochodnický, Peter, Cruz, Célia D., Yoshimura, Naoki, Michel, Martin C.

“…In the last two decades, nerve growth factor (NGF), initially described as a prototypical trophic factor in the development of sensory and sympathetic…”
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Expression profiling of G‐protein‐coupled receptors in human urothelium and related cell lines by Ochodnický, Peter, Humphreys, Sian, Eccles, Rachel, Poljakovic, Mirjana, Wiklund, Peter, Michel, Martin C.

“…What's known on the subject? and What does the study add? Urothelium emerged as a crucial integrator of sensory inputs and outputs in the bladder wall, and…”
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Bradykinin modulates spontaneous nerve growth factor production and stretch-induced ATP release in human urothelium by Ochodnický, Peter, Michel, Martina B., Butter, Jan J., Seth, Jai, Panicker, Jalesh N., Michel, Martin C.

“…The urothelium plays a crucial role in integrating urinary bladder sensory outputs, responding to mechanical stress and chemical stimulation by producing…”
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Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat by Ochodnický, Peter, Henning, Robert H, Buikema, Hendrik J, de Zeeuw, Dick, Provoost, Abraham P, van Dokkum, Richard P E

“…It is unknown whether generalized vascular dysfunction precedes the development of kidney disease. Therefore, we studied myogenic constriction and…”
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The role of angiotensin(1–7) in renal vasculature of the rat by van der Wouden, Els A, Ochodnický, Peter, van Dokkum, Richard PE, Roks, Anton JM, Deelman, Leo E, de Zeeuw, Dick, Henning, Robert H

“…OBJECTIVEAngiotensin(1–7) is an active component of the renin–angiotensin–aldosterone system. Its exact role in renal vascular function is unclear. We…”
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Endothelial function predicts the development of renal damage after combined nephrectomy and myocardial infarction by OCHODNICKY, Peter, DE ZEEUW, Dick, HENNING, Robert H, KLUPPEL, C. Alex, VAN DOKKUM, Richard P. E

“…It was demonstrated that individual renal endothelial dilatory function of the healthy rat predicts susceptibility to subsequent renal damage induced by 5/6…”
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Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney by Rampanelli, Elena, Ochodnicky, Peter, Vissers, Johannes PC, Butter, Loes M, Claessen, Nike, Calcagni, Alessia, Kors, Lotte, Gethings, Lee A, Bakker, Stephan JL, de Borst, Martin H, Navis, Gerjan J, Liebisch, Gerhard, Speijer, Dave, van den Bergh Weerman, Marius A, Jung, Bettina, Aten, Jan, Steenbergen, Eric, Schmitz, Gerd, Ballabio, Andrea, Florquin, Sandrine, Aerts, Johannes MFG, Leemans, Jaklien C

“…Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic…”
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Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation by Rampanelli, Elena, Orsó, Evelyn, Ochodnicky, Peter, Liebisch, Gerhard, Bakker, Pieter J., Claessen, Nike, Butter, Loes M., van den Bergh Weerman, Marius A., Florquin, Sandrine, Schmitz, Gerd, Leemans, Jaklien C.

“…The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of…”
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Specificity evaluation of antibodies against human β3-adrenoceptors by Cernecka, Hana, Ochodnicky, Peter, Lamers, Wouter H., Michel, Martin C.

“…β 3 -Adrenoceptors are a promising drug target for the treatment of urinary bladder dysfunction, but knowledge about their expression at the protein level and…”
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Microalbuminuria and Endothelial Dysfunction: Emerging Targets for Primary Prevention of End-organ Damage by Ochodnicky, Peter, Henning, Robert H, van Dokkum, Richard P.E, de Zeeuw, Dick

“…A minor increase in urinary albumin excretion (microalbuminuria) is known to predict adverse renal and cardiovascular events in diabetic and hypertensive…”
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Gene expression profiling of G‐protein coupled receptors in human urothelial cell lines by Ochodnicky, Peter, Humphreys, Sian, Eccles, Rachel, Poljakovic, Mirjana, Wiklund, Peter, Michel, Martin C.

“…Urothelium contributes to the regulation of urinary bladder function and hence could be a novel drug target for bladder dysfunction. As fresh human urothelium…”
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Altered myogenic constriction and endothelium-derived hyperpolarizing factor-mediated relaxation in small mesenteric arteries of hypertensive subtotally nephrectomized rats by Vettoretti, Simone, Ochodnicky, Peter, Buikema, Hendrik, Henning, Rob H, Kluppel, C Alex, de Zeeuw, Dick, van Dokkum, Richard P E

“…Chronic renal failure (CRF) is associated with altered systemic arterial tone and hypertension. Myogenic constriction and endothelium-derived hyperpolarizing…”
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Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats by Klimas, Jan, Olvedy, Michael, Ochodnicka‐Mackovicova, Katarina, Kruzliak, Peter, Cacanyiova, Sona, Kristek, Frantisek, Krenek, Peter, Ochodnicky, Peter

“…Since the identification of the alternative angiotensin converting enzyme (ACE)2/Ang‐(1‐7)/Mas receptor axis, renin‐angiotensin system (RAS) is a new complex…”
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Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function by Krenek, Peter, Kmecova, Jana, Kucerova, Dana, Bajuszova, Zuzana, Musil, Peter, Gazova, Andrea, Ochodnicky, Peter, Klimas, Jan, Kyselovic, Jan

“…Aims The role of nitric oxide (NO) in heart failure (HF) is complex and remains controversial. We tested the hypothesis that the role of NO in isolated atria…”
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High glucose induces HGF-independent activation of Met receptor in human renal tubular epithelium by Mesarosova, Lucia, Ochodnicky, Peter, Leemans, Jaklien C., Florquin, Sandrine, Krenek, Peter, Klimas, Jan

“…Context: The role of hepatocyte growth factor (HGF) in diabetic kidney damage remains controversial. Objective: To test the hypothesis that high glucose levels…”
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Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy by Ochodnicky, Peter, Lattenist, Lionel, Ahdi, Mohamed, Kers, Jesper, Uil, Melissa, Claessen, Nike, Leemans, Jaklien C., Florquin, Sandrine, Meijers, Joost C.M., Gerdes, Victor E.A., Roelofs, Joris J.T.H.

“…TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity. Circulating TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to…”
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β-adrenoceptor agonist effects in experimental models of bladder dysfunction by Michel, Martin C, Ochodnicky, Peter, Homma, Yukio, Igawa, Yasuhiko

“…β-adrenoceptor stimulation can enhance the storage function of the urinary bladder by acting on detrusor smooth muscle tone, mediator release from the…”
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Desirable properties of β₃-adrenoceptor agonists: Implications for the selection of drug development candidates by Michel, Martin C, Cernecka, Hana, Ochodnicky, Peter

“…β₃-adrenoceptor agonists are currently in clinical development for the treatment of overactive bladder and considered for several other indications. This…”
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Renal endothelial function is associated with the anti-proteinuric effect of ACE inhibition in 5/6 nephrectomized rats by Vettoretti, Simone, Vavrinec, Peter, Ochodnicky, Peter, Deelman, Leo E, De Zeeuw, Dick, Henning, Rob H, Buikema, Hendrik

“…In healthy rats, the physiological variation of baseline endothelial function of intrarenal arteries correlates with the severity of renal damage in response…”
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Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy by Cernecka, Hana, Ochodnicka-Mackovicova, Katarina, Kucerova, Dana, Kmecova, Jana, Nemcekova, Viera, Doka, Gabriel, Kyselovic, Jan, Krenek, Peter, Ochodnicky, Peter, Klimas, Jan

“…Anthracycline therapy is limited by a cardiotoxicity that may eventually lead to chronic heart failure which is thought to be prevented by ACE inhibitors…”
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