Search Results - "Ocean, Allyson"

Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer by Bardia, Aditya, Mayer, Ingrid A, Diamond, Jennifer R, Moroose, Rebecca L, Isakoff, Steven J, Starodub, Alexander N, Shah, Nikita C, O'Shaughnessy, Joyce, Kalinsky, Kevin, Guarino, Michael, Abramson, Vandana, Juric, Dejan, Tolaney, Sara M, Berlin, Jordan, Messersmith, Wells A, Ocean, Allyson J, Wegener, William A, Maliakal, Pius, Sharkey, Robert M, Govindan, Serengulam V, Goldenberg, David M, Vahdat, Linda T

“…Purpose Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an…”
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First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors by Starodub, Alexander N, Ocean, Allyson J, Shah, Manish A, Guarino, Michael J, Picozzi, Jr, Vincent J, Vahdat, Linda T, Thomas, Sajeve S, Govindan, Serengulam V, Maliakal, Pius P, Wegener, William A, Hamburger, Steven A, Sharkey, Robert M, Goldenberg, David M

“…Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2, a surface glycoprotein expressed on many epithelial tumors, for delivery…”
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Sacituzumab govitecan (IMMU‐132), an anti‐Trop‐2‐SN‐38 antibody‐drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics by Ocean, Allyson J., Starodub, Alexander N., Bardia, Aditya, Vahdat, Linda T., Isakoff, Steven J., Guarino, Michael, Messersmith, Wells A., Picozzi, Vincent J., Mayer, Ingrid A., Wegener, William A., Maliakal, Pius, Govindan, Serengulam V., Sharkey, Robert M., Goldenberg, David M.

“…BACKGROUND Sacituzumab govitecan (IMMU‐132), an antitrophoblastic cell‐surface antigen (anti‐Trop‐2) humanized antibody‐SN‐38 conjugate, had encouraging…”
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Therapy of Advanced Non-Small-Cell Lung Cancer With an SN-38-Anti-Trop-2 Drug Conjugate, Sacituzumab Govitecan by Heist, Rebecca Suk, Guarino, Michael J, Masters, Gregory, Purcell, W Thomas, Starodub, Alexander N, Horn, Leora, Scheff, Ronald J, Bardia, Aditya, Messersmith, Wells A, Berlin, Jordan, Ocean, Allyson J, Govindan, Serengulam V, Maliakal, Pius, Mudenda, Boyd, Wegener, William A, Sharkey, Robert M, Goldenberg, David M, Camidge, D Ross

“…Purpose Trop-2, expressed in most solid cancers, may be a target for antibody-drug conjugates (ADCs) in non-small-cell lung cancer (NSCLC). We studied…”
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Peripheral Neuropathy with Microtubule-Targeting Agents: Occurrence and Management Approach by Carlson, Karen, Ocean, Allyson J

“…Abstract Microtubule-targeting agents (MTAs), which include vinca alkaloids, taxanes, and the recently introduced epothilone, ixabepilone, are widely used…”
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Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study by Navi, Babak B., Sherman, Carla P., Genova, Richard, Mathias, Ryna, Lansdale, Kelsey N., LeMoss, Natalie M., Wolfe, Julia, Skakodub, Anna, Kamel, Hooman, Tagawa, Scott T., Saxena, Ashish, Ocean, Allyson J., Soff, Gerald A., DeSancho, Maria T., Iadecola, Costantino, Elkind, Mitchell S.V., Peerschke, Ellinor, Zhang, Cenai, DeAngelis, Lisa M.

“…Objective The objective of this study was to examine the pathophysiology of ischemic stroke with cancer. Methods We conducted a prospective cross‐sectional…”
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Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I-inhibiting Antibody-Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan by Gray, Jhanelle E, Heist, Rebecca S, Starodub, Alexander N, Camidge, D Ross, Kio, Ebenezer A, Masters, Gregory A, Purcell, W Thomas, Guarino, Michael J, Misleh, Jamal, Schneider, Charles J, Schneider, Bryan J, Ocean, Allyson, Johnson, Tirrell, Gandhi, Leena, Kalinsky, Kevin, Scheff, Ronald, Messersmith, Wells A, Govindan, Serengulam V, Maliakal, Pius P, Mudenda, Boyd, Wegener, William A, Sharkey, Robert M, Goldenberg, David M

“…We evaluated a Trop-2-targeting antibody conjugated with SN-38 in metastatic small cell lung cancer (mSCLC) patients. Sacituzumab govitecan was studied in…”
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Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with KRAS -Mutated Colorectal Cancer by Goel, Sanjay, Ocean, Allyson J, Parakrama, Ruwan Y, Ghalib, Mohammad H, Chaudhary, Imran, Shah, Umang, Viswanathan, Sengottuvel, Kharkwal, Himanshu, Coffey, Matthew, Maitra, Radhashree

“…mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target…”
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Ischemic Stroke with Comorbid Cancer Has Specific miRNA-mRNA Networks in Blood That Vary by Ischemic Stroke Mechanism by Knepp, Bodie, Navi, Babak B, Rodriguez, Fernando, DeAngelis, Lisa M, Elkind, Mitchell S V, Iadecola, Costantino, Sherman, Carla P, Tagawa, Scott T, Saxena, Ashish, Ocean, Allyson J, Hull, Heather, Jickling, Glen, Sharp, Frank R, Ander, Bradley P, Stamova, Boryana

“…Approximately half of ischemic strokes (IS) in cancer patients are cryptogenic, with many presumed cardioembolic. We evaluated whether there were specific…”
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Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer by Kasi, Pashtoon Murtaza, Hidalgo, Manuel, Jafari, Mehraneh D., Yeo, Heather, Lowenfeld, Lea, Khan, Uqba, Nguyen, Alana T. H., Siolas, Despina, Swed, Brandon, Hyun, Jini, Khan, Sahrish, Wood, Madeleine, Samstein, Benjamin, Rocca, Juan P., Ocean, Allyson J., Popa, Elizabeta C., Hunt, Daniel H., Uppal, Nikhil P., Garrett, Kelly A., Pigazzi, Alessio, Zhou, Xi Kathy, Shah, Manish A., Hissong, Erika

“…In patients with locally advanced cancer without distant metastases, the neoadjuvant setting presents a platform to evaluate new drugs. For mismatch repair…”
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Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response by Schneider, Bryan J, Shah, Manish A, Klute, Kelsey, Ocean, Allyson, Popa, Elizabeta, Altorki, Nasser, Lieberman, Michael, Schreiner, Andrew, Yantiss, Rhonda, Christos, Paul J, Palmer, Romae, You, Daoqi, Viale, Agnes, Kermani, Pouneh, Scandura, Joseph M

“…Epigenetic silencing of tumor suppressor genes (TSG) is an acquired abnormality observed in cancer and is prototypically linked to DNA methylation. We…”
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Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation by Papaspyridonos, Marianna, Matei, Irina, Huang, Yujie, do Rosario Andre, Maria, Brazier-Mitouart, Helene, Waite, Janelle C., Chan, April S., Kalter, Julie, Ramos, Ilyssa, Wu, Qi, Williams, Caitlin, Wolchok, Jedd D., Chapman, Paul B., Peinado, Hector, Anandasabapathy, Niroshana, Ocean, Allyson J., Kaplan, Rosandra N., Greenfield, Jeffrey P., Bromberg, Jacqueline, Skokos, Dimitris, Lyden, David

“…A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive ‘macroenvironment’ mediated in part through…”
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Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes by Navi, Babak B., Zhang, Cenai, Sherman, Carla P., Genova, Richard, LeMoss, Natalie M., Kamel, Hooman, Tagawa, Scott T., Saxena, Ashish, Ocean, Allyson J., Kasner, Scott E., Cushman, Mary, Elkind, Mitchell S. V., Peerschke, Ellinor, DeAngelis, Lisa M.

“…Background Patients with cancer and acute ischemic stroke (AIS) face high rates of recurrent thromboembolism or death. Objectives To examine whether…”
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Phase II Trial Evaluating the Clinical and Biologic Effects of Bevacizumab in Unresectable Hepatocellular Carcinoma by SIEGEL, Abby B, COHEN, Emil I, CHRISTOS, Paul, MAZUMDAR, Madhu, POPA, Elizabeta, BROWN, Robert S, RAFII, Shahin, SCHWARTZ, Jonathan D, OCEAN, Allyson, LEHRER, Deborah, GOLDENBERG, Alec, KNOX, Jennifer J, CHEN, Helen, CLARK-GARVEY, Sean, WEINBERG, Alan, MANDELI, John

“…To determine the clinical and biologic effects of bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in unresectable…”
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A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study by Rodriguez, Nicolette J., Furniss, C. Sloane, Yurgelun, Matthew B., Ukaegbu, Chinedu, Constantinou, Pamela E., Fortes, Ileana, Caruso, Alyson, Schwartz, Alison N., Stopfer, Jill E., Underhill-Blazey, Meghan, Kenner, Barbara, Nelson, Scott H., Okumura, Sydney, Zhou, Alicia Y., Coffin, Tara B., Uno, Hajime, Horiguchi, Miki, Ocean, Allyson J., McAllister, Florencia, Lowy, Andrew M., Klein, Alison P., Madlensky, Lisa, Petersen, Gloria M., Garber, Judy E., Lippman, Scott M., Goggins, Michael G., Maitra, Anirban, Syngal, Sapna

“…Genetic testing uptake for cancer susceptibility in family members of patients with cancer is suboptimal. Among relatives of patients with pancreatic ductal…”
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Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome by Shah, Manish A, Enzinger, Peter, Ko, Andrew H, Ocean, Allyson J, Philip, Philip Agop, Thakkar, Prashant V, Cleveland, Kyle, Lu, Yao, Kortmansky, Jeremy, Christos, Paul J, Zhang, Chao, Kaur, Navjot, Elmonshed, Dina, Galletti, Giuseppe, Sarkar, Sandipto, Bhinder, Bhavneet, Pittman, Meredith E, Plotnikova, Olga Mikhaylovna, Kotlov, Nikita, Frenkel, Felix, Bagaev, Aleksander, Elemento, Olivier, Betel, Doron, Giannakakou, Paraskevi, Lenz, Heinz-Josef

“…We examined cabazitaxel, a novel next-generation taxoid, in patients with metastatic gastric cancer in a multicenter phase II study. Patients who have…”
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Chemotherapy dose intensity predicted by baseline nutrition assessment in gastrointestinal malignancies: A multicentre analysis by Klute, Kelsey A, Brouwer, Julianna, Jhawer, Minaxi, Sachs, Hayley, Gangadin, Anatasia, Ocean, Allyson, Popa, Elizabeta, Dai, Tong, Wu, Guojiao, Christos, Paul, Shah, Manish A

“…Abstract Background Malnutrition is prevalent in cancer patients and is associated with inferior outcomes. We examined the association between malnutrition, as…”
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver by Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David

“…Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular…”
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Sacituzumab Govitecan, a Novel Antibody–Drug Conjugate, in Patients With Metastatic Platinum-Resistant Urothelial Carcinoma by Faltas, Bishoy, Goldenberg, David M, Ocean, Allyson J, Govindan, Serengulam V, Wilhelm, Francois, Sharkey, Robert M, Hajdenberg, Julio, Hodes, Gillian, Nanus, David M, Tagawa, Scott T

“…Abstract Patients with metastatic, platinum-resistant urothelial carcinoma (PRUC) have no Food and Drug Administration–approved therapies. The response rates…”
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Cancer-Related Ischemic Stroke Has a Distinct Blood mRNA Expression Profile by Navi, Babak B, Mathias, Ryna, Sherman, Carla P, Wolfe, Julia, Kamel, Hooman, Tagawa, Scott T, Saxena, Ashish, Ocean, Allyson J, Iadecola, Costantino, DeAngelis, Lisa M, Elkind, Mitchell S.V, Hull, Heather, Jickling, Glen C, Sharp, Frank R, Ander, Bradley P, Stamova, Boryana

“…BACKGROUND AND PURPOSE—Comorbid cancer is common in patients with acute ischemic stroke (AIS). As blood mRNA profiles can distinguish AIS mechanisms, we…”
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