Search Results - "Ocampo, Alejandro"

Regulation of Stem Cell Aging by Metabolism and Epigenetics by Ren, Ruotong, Ocampo, Alejandro, Liu, Guang-Hui, Izpisua Belmonte, Juan Carlos

“…Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated declines in stem cell function are characterized by…”
Get full text

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming by Ocampo, Alejandro, Reddy, Pradeep, Martinez-Redondo, Paloma, Platero-Luengo, Aida, Hatanaka, Fumiyuki, Hishida, Tomoaki, Li, Mo, Lam, David, Kurita, Masakazu, Beyret, Ergin, Araoka, Toshikazu, Vazquez-Ferrer, Eric, Donoso, David, Roman, Jose Luis, Xu, Jinna, Rodriguez Esteban, Concepcion, Nuñez, Gabriel, Nuñez Delicado, Estrella, Campistol, Josep M., Guillen, Isabel, Guillen, Pedro, Izpisua Belmonte, Juan Carlos

“…Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age,…”
Get full text

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling by Pan, Yong, Schroeder, Elizabeth A., Ocampo, Alejandro, Barrientos, Antoni, Shadel, Gerald S.

“…Here we show that yeast strains with reduced target of rapamycin (TOR) signaling have greater overall mitochondrial electron transport chain activity during…”
Get full text

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging by Zhang, Weiqi, Li, Jingyi, Suzuki, Keiichiro, Qu, Jing, Wang, Ping, Zhou, Junzhi, Liu, Xiaomeng, Ren, Ruotong, Xu, Xiuling, Ocampo, Alejandro, Yuan, Tingting, Yang, Jiping, Li, Ying, Shi, Liang, Guan, Dee, Pan, Huize, Duan, Shunlei, Ding, Zhichao, Li, Mo, Yi, Fei, Bai, Ruijun, Wang, Yayu, Chen, Chang, Yang, Fuquan, Li, Xiaoyu, Wang, Zimei, Aizawa, Emi, Goebl, April, Soligalla, Rupa Devi, Reddy, Pradeep, Esteban, Concepcion Rodriguez, Tang, Fuchou, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua

“…Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic…”
Get full text

Selective elimination of mitochondrial mutations in the germline by genome editing by Reddy, Pradeep, Ocampo, Alejandro, Suzuki, Keiichiro, Luo, Jinping, Bacman, Sandra R, Williams, Sion L, Sugawara, Atsushi, Okamura, Daiji, Tsunekawa, Yuji, Wu, Jun, Lam, David, Xiong, Xiong, Montserrat, Nuria, Esteban, Concepcion Rodriguez, Liu, Guang-Hui, Sancho-Martinez, Ignacio, Manau, Dolors, Civico, Salva, Cardellach, Francesc, Del Mar O'Callaghan, Maria, Campistol, Jaime, Zhao, Huimin, Campistol, Josep M, Moraes, Carlos T, Izpisua Belmonte, Juan Carlos

“…Mitochondrial diseases include a group of maternally inherited genetic disorders caused by mutations in mtDNA. In most of these patients, mutated mtDNA…”
Get full text

Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes by Kim, Min Woo, Ahn, Ki Hoon, Ryu, Ki-Jin, Hong, Soon-Cheol, Lee, Ji Sung, Nava-Ocampo, Alejandro A, Oh, Min-Jeong, Kim, Hai-Joong

“…Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube…”
Get full text

Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry by Ocampo, Alejandro, Barrientos, Antoni

“…• We present a new method to assess yeast chronological life span (CLS). • The method involves staining with propidium iodide (PI) and flow cytometry (FCM). •…”
Get full text

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction by Suzuki, Keiichiro, Yamamoto, Mako, Hernandez-Benitez, Reyna, Li, Zhe, Wei, Christopher, Soligalla, Rupa Devi, Aizawa, Emi, Hatanaka, Fumiyuki, Kurita, Masakazu, Reddy, Pradeep, Ocampo, Alejandro, Hishida, Tomoaki, Sakurai, Masahiro, Nemeth, Amy N., Nuñez Delicado, Estrella, Campistol, Josep M., Magistretti, Pierre, Guillen, Pedro, Rodriguez Esteban, Concepcion, Gong, Jianhui, Yuan, Yilin, Gu, Ying, Liu, Guang-Hui, López-Otín, Carlos, Wu, Jun, Zhang, Kun, Izpisua Belmonte, Juan Carlos

“…In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to…”
Get full text

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21 by Agius, Thomas, Emsley, Raffaella, Lyon, Arnaud, MacArthur, Michael R., Kiesworo, Kevin, Faivre, Anna, Stavart, Louis, Lambelet, Martine, Legouis, David, de Seigneux, Sophie, Golshayan, Déla, Lazeyras, Francois, Yeh, Heidi, Markmann, James F., Uygun, Korkut, Ocampo, Alejandro, Mitchell, Sarah J., Allagnat, Florent, Déglise, Sébastien, Longchamp, Alban

“…Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term…”
Get full text

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells by Sancho-Martinez, Ignacio, Nivet, Emmanuel, Xia, Yun, Hishida, Tomoaki, Aguirre, Aitor, Ocampo, Alejandro, Ma, Li, Morey, Robert, Krause, Marie N., Zembrzycki, Andreas, Ansorge, Olaf, Vazquez-Ferrer, Eric, Dubova, Ilir, Reddy, Pradeep, Lam, David, Hishida, Yuriko, Wu, Min-Zu, Esteban, Concepcion Rodriguez, O’Leary, Dennis, Wahl, Geoffrey M., Verma, Inder M., Laurent, Louise C., Izpisua Belmonte, Juan Carlos

“…Glioma tumour-initiating cells (GTICs) can originate upon the transformation of neural progenitor cells (NPCs). Studies on GTICs have focused on primary…”
Get full text

Is headache during pregnancy a higher risk for serious secondary headache cause? A HEAD study report by Kelly, Anne‐Maree, Chu, Kevin H, Kuan, Win Sen, Keijzers, Gerben, Kinnear, Frances B, Cardozo‐Ocampo, Alejandro

“…Objectives Pregnancy is defined as a ‘red flag’ in headache assessment. We aimed to describe the prevalence and causes of serious secondary headache in…”
Get full text

Repression of small toxic protein synthesis by the Sib and OhsC small RNAs by Fozo, Elizabeth M, Kawano, Mitsuoki, Fontaine, Fanette, Kaya, Yusuf, Mendieta, Kathy S, Jones, Kristi L, Ocampo, Alejandro, Rudd, Kenneth E, Storz, Gisela

“…The sequences encoding the QUAD1 RNAs were initially identified as four repeats in Escherichia coli. These repeats, herein renamed SIB, are conserved in…”
Get full text

Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation by Villarreal-Reyna, Gustavo, Garza-Morales, Rodolfo, Soto-Domínguez, Adolfo, Montañez-Guerrero, Lorena, Saucedo-Cárdenas, Odila, Gómez-Flores, Minerva, Ocampo-Garza, Jorge Alejandro, Pérez-Trujillo, José Juan, Montes-de-Oca-Luna, Roberto

“…Hair graying, a prototypical sign of human aging, is a progressive loss of pigmentation from growing hair shafts caused by disease and as a side effect of…”
Get full text

Association between the CTLA4 +49A/G (rs231775) and CT60 (rs3087243) gene variants with vitiligo: study on a Mexican population by Salinas-Santander, Mauricio Andrés, Suárez-Valencia, Víctor de Jesús, Ángel-Martínez, Mayela del, Kubelis-Lopez, David Emmanuel, Zapata-Salazar, Natalia Aranza, Ocampo-Garza, Jorge Alejandro, Ocampo-Candiani, Jorge

“…Vitiligo is characterized by an autoimmune response targeting melanocytes, thus resulting in skin depigmentation. There are several genetic components involved…”
Get full text

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging by Paine, Patrick Treat, Rechsteiner, Cheyenne, Morandini, Francesco, Desdín-Micó, Gabriela, Mrabti, Calida, Parras, Alberto, Haghani, Amin, Brooke, Robert, Horvath, Steve, Seluanov, Andrei, Gorbunova, Vera, Ocampo, Alejandro

“…Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can…”
Get full text

Hydrodynamic and experimental characterization of pumps as turbines by Tobón-Espinosa, Daniel Felipe, Mejía-Ocampo, David Alejandro, Moreno-Sánchez, Ricardo, Botero-Herrera, Francisco Javier

“…To estimate the performance, efficacy, modes of operation, hydrodynamic instabilities, and methodologies for harnessing energy from the pump as turbine (PAT),…”
Get full text

Dose-response and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure by Kwak, Ho-Seok, Han, Jung-Yeol, Choi, June-Seek, Ahn, Hyun-Kyong, Kwak, Dong-Wook, Lee, Yeon-Kyung, Koh, Sun-Young, Jeong, Go-Un, Velázquez-Armenta, E. Yadira, Nava-Ocampo, Alejandro A.

“…ABSTRACT Objectives Little is known on how the dose and timing of exposure co‐influence the cumulative concentration of fatty acid ethyl esters (FAEEs) in…”
Get full text

Fetal and neonatal outcomes in women reporting ingestion of licorice (Glycyrrhiza uralensis) during pregnancy by Choi, June-Seek, Han, Jung-Yeol, Ahn, Hyun-Kyong, Ryu, Hyun-Mee, Kim, Moon-Young, Chung, Jin-Hoon, Nava-Ocampo, Alejandro A, Koren, Gideon

“…Maternal intake of licorice from dietary sources has been associated with adverse maternal and fetal outcomes. We prospectively studied the outcome of 185…”
Get more information

Could a first-trimester blood phosphatidylethanol concentration ⩾4 nM be useful to identify women with moderate-to-heavy prenatal alcohol exposure who are at high risk of adverse pregnancy outcomes? by Yang, Jun-Young, Kwak, Ho-Seok, Han, Jung-Yeol, Choi, June-Seek, Ahn, Hyun-Kyong, Oh, Young-Jun, Velázquez-Armenta, E. Yadira, Nava-Ocampo, Alejandro A

“…Abstract It is accepted that blood phosphatidylethanol (PEth) concentrations are reliable biomarkers of ethanol (alcohol) exposure. We therefore conducted a…”
Get full text

From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders by Ocampo, Alejandro, Barrientos, Antoni

“…In the last decade, the budding yeast Saccharomyces cerevisiae has been used as a model system to study the mechanisms of the human aging process and of…”
Get full text