Search Results - "Obunike, J."

Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages by RUMSEY, S. C, OBUNIKE, J. C, ARAD, Y, DECKELBAUM, R. J, GOLDBERG, I. J

“…Lipoprotein lipase (LPL), the rate limiting enzyme for hydrolysis of lipoprotein triglyceride, also mediates nonenzymatic interactions between lipoproteins and…”
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Lipoprotein lipase hydrolysis of retinyl ester: possible implications for retinoid uptake by cells by Blaner, W.S, Obunike, J.C, Kurlandsky, S.B, Al-Haideri, M, Piantedos, R, Deckelbaum, R.F, Goldberg, I.J

“…Adipose tissue contains substantial stores of retinoid (retinol + retinyl ester) that, quantitatively, are second only to retinoid stores in the liver. Our…”
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The Heparin-Binding Proteins Apolipoprotein E and Lipoprotein Lipase Enhance Cellular Proteoglycan Production by Obunike, Joseph C, Pillarisetti, Sivaram, Paka, Latha, Kako, Yuko, Butteri, Mathew J, Ho, Yuan-Yaun, Wagner, William D, Yamada, Nobuhiro, Mazzone, Theodore, Deckelbaum, Richard J, Goldberg, Ira J

“…Apolipoprotein E (apoE) and lipoprotein lipase (LPL), key proteins in the regulation of lipoprotein metabolism, bind with high affinity to heparin and…”
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Lipoprotein Lipase Can Function as a Monocyte Adhesion Protein by Obunike, Joseph C, Paka, Swarnalatha, Pillarisetti, Sivaram, Goldberg, Ira J

“…Lipoprotein lipase (LPL) is made by several cell types, including macrophages within the atherosclerotic lesion. LPL, a dimer of identical subunits, has high…”
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Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins by Obunike, J.C, Edwards, I.J, Rumsey, S.C, Curtiss, L.K, Wagner, W.D, Deckelbaum, R.J, Goldberg, I.J

“…Lipoprotein lipase (LPL) increases the cellular uptake and degradation of LDL by fibroblasts and macrophages via a heparin-sensitive process. The roles of the…”
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Transcytosis of Lipoprotein Lipase across Cultured Endothelial Cells Requires Both Heparan Sulfate Proteoglycans and the Very Low Density Lipoprotein Receptor by Obunike, Joseph C., Lutz, E. Peer, Li, Zhaohui, Paka, Lata, Katopodis, Tommy, Strickland, Dudley K., Kozarsky, Karen F., Pillarisetti, Sivaram, Goldberg, Ira J.

“…Lipoprotein lipase (LPL), the major enzyme responsible for the hydrolysis of circulating lipoprotein triglyceride molecules, is synthesized in myocytes and…”
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Subendothelial retention of lipoprotein (a). Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix by Pillarisetti, S, Paka, L, Obunike, J C, Berglund, L, Goldberg, I J

“…Vessel wall subendothelial extracellular matrix, a dense mesh formed of collagens, fibronectin, laminin, and proteoglycans, has important roles in lipid and…”
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High Affinity Binding between Lipoprotein Lipase and Lipoproteins Involves Multiple Ionic and Hydrophobic Interactions, Does Not Require Enzyme Activity, and Is Modulated by Glycosaminoglycans by Hussain, M. Mahmood, Obunike, Joseph C., Shaheen, Afsar, Hussain, M. Jawaad, Shelness, Gregory S., Goldberg, Ira J.

“…Lipoprotein lipase (LPL) physically associates with lipoproteins and hydrolyzes triglycerides. To characterize the binding of LPL to lipoproteins, we studied…”
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Apolipoprotein E containing high density lipoprotein stimulates endothelial production of heparan sulfate rich in biologically active heparin-like domains. A potential mechanism for the anti-atherogenic actions of vascular apolipoprotein e by Paka, L, Kako, Y, Obunike, J C, Pillarisetti, S

“…Reduced heparin and heparan sulfate (HS) proteoglycans (PG) have been observed in both inflammation and atherosclerosis. Methods to increase endogenous heparin…”
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Influence of glucose on production and N-sulfation of heparan sulfate in cultured adipocyte cells by Parthasarathy, N, Gotow, L F, Bottoms, J D, Obunike, J C, Naggi, A, Casu, B, Goldberg, I J, Wagner, W D

“…Altered lipoprotein lipase regulation associated with diabetes leading to the development of hypertriglyceridemia might be attributed to possible changes in…”
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Perlecan mediates the antiproliferative effect of apolipoprotein E on smooth muscle cells. An underlying mechanism for the modulation of smooth muscle cell growth? by Paka, L, Goldberg, I J, Obunike, J C, Choi, S Y, Saxena, U, Goldberg, I D, Pillarisetti, S

“…Apolipoprotein E (apoE) is known to inhibit cell proliferation; however, the mechanism of this inhibition is not clear. We recently showed that apoE stimulates…”
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Lipoprotein lipase degradation by adipocytes: receptor-associated protein (RAP)-sensitive and proteoglycan-mediated pathways by Obunike, J C, Sivaram, P, Paka, L, Low, M G, Goldberg, I J

“…Lipoprotein lipase (LPL), the major enzyme responsible for the hydrolysis of triglycerides, is primarily synthesized by adipocytes and myocytes. In addition to…”
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Differentiated Macrophages Synthesize a Heparan Sulfate Proteoglycan and an Oversulfated Chondroitin Sulfate Proteoglycan That Bind Lipoprotein Lipase by Edwards, Iris J, Xu, Hongzhi, Obunike, Joseph C, Goldberg, Ira J, Wagner, William D

“…Lipoprotein lipase (LpL), which facilitates lipoprotein uptake by macrophages, associates with the cell surface by binding to proteoglycans (PGs). Studies were…”
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Lysolecithin-induced Alteration of Subendothelial Heparan Sulfate Proteoglycans Increases Monocyte Binding to Matrix (∗) by Sivaram, Pillarisetti, Obunike, Joseph C., Goldberg, Ira J.

“…The cause and consequence of altered proteoglycans in atherosclerosis are poorly understood. To determine whether proteoglycans affect monocyte binding, we…”
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Catechin and sulfated polysaccharide nutriceuticals inhibit MMP-2 (gelatinase-A) of fibroblasts cultured from abdominal aortic aneurysms (AAAs) by Belsley, S.J., Obunike, J., Collin, P., Tilson, M.D.

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3.P.300 Oxidized LDL and lysolecithin induced decrease in subendothelial heparan sulfate is due to the actions of an endothelial heparanase by Pillarisetti, S., Paka, S., Obunike, J., Goldberg, I.J.

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Differential macrophages synthesize a heparan sulfate proteoglycan and an oversulfated chondroitin sulfate proteoglycan that bind lipoprotein lipase by EDWARDS, I. J, HONGZHI XU, OBUNIKE, J. C, GOLDBERG, I. J, WAGNER, W. D

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