Search Results - "Obukowicz, Mark G"

The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation by Hu, Xiao, Du, Sarah, Tunca, Cansu, Braden, Timothy, Long, Kelly R, Lee, Jamie, Webb, Elizabeth G, Dietz, Jessica D, Hummert, Susan, Rouw, Sharon, Hegde, Shridhar G, Webber, R. Keith, Obukowicz, Mark G

“…A synthetic glucocorticoid receptor (GR) ligand with the efficacy of a glucocorticoid, but without the accompanying side effects, would meet an unmet medical…”
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Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2 by Levin, Galit, Duffin, Kevin L, Obukowicz, Mark G, Hummert, Susan L, Fujiwara, Hideji, Needleman, Philip, Raz, Amiram

“…Prostaglandin (PG) E(1) has been shown to possess anti-inflammatory properties and to modulate vascular reactivity. These activities are sometimes distinct…”
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Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis by Hansen-Petrik, Melissa B, McEntee, Michael F, Johnson, Benjamin T, Obukowicz, Mark G, Masferrer, Jaime, Zweifel, Ben, Chiu, Chun-Hung, Whelan, Jay

“…Arachidonic acid is an important polyunsaturated fatty acid involved in cell signaling. It is derived primarily from dietary linoleic acid, and the…”
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Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats by Chinn, Kevin S., Welsch, Dean J., Salsgiver, William J., Mehta, Aniali, Raz, Amiram, Obukowicz, Mark G.

“…Controlled feeding of linoleic acid (LA) or arachidonic acid (AA) to essential fatty acid‐deficient (EFAD) rats was used to define the relationship between…”
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Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice by Petrik, M B, McEntee, M F, Johnson, B T, Obukowicz, M G, Whelan, J

“…We showed previously that dietary eicosapentaenoic acid [EPA, 20:5(n-3)] is antitumorigenic in the APC:(Min/+) mouse, a genetic model of intestinal…”
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Secretion of active kringle-2-serine protease in Escherichia coli by Obukowicz, Mark G, Gustafson, Mark E, Junger, Kurt D, Leimgruber, Richard M, Wittwer, Arthur J, Wun, Tze Chein, Warren, Thomas G, Bishop, Bruce F, Mathis, Karl J

“…Active human tissue plasminogen activator variant kringle-2-serine protease (K2 + SP domains; referred to as MB1004) was synthesized as a secreted protein in…”
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Lipid remodeling in mouse liver and plasma resulting from Δ6 fatty acid desaturase inhibition by Duffin, Kevin L., Obukowicz, Mark G., Salsgiver, William J., Welsch, Dean J., Shieh, Caroline, Raz, Amiram, Needleman, Philip

“…Electrospray/tandem mass spectrometry was used to quantify lipid remodeling in mouse liver and plasma during inhibition of polyunsaturated fatty acid synthesis…”
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Identification and Characterization of a Novel Δ6/Δ5 Fatty Acid Desaturase Inhibitor As a Potential Anti-Inflammatory Agent by Obukowicz, Mark G., Raz, Amiram, Pyla, Paul D., Rico, Joseph G., Wendling, Jay M., Needleman, Philip

“…The anti-inflammatory properties of essential fatty acid deficiency or n-3 polyunsaturated fatty acid supplementation have been attributed to a reduced content…”
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Fish oil inhibits Δ6 desaturase activity in vivo: Utility in a dietary paradigm to obtain mice depleted of arachidonic acid by Raz, Amiram, Kamin-Belsky, Nurit, Przedecki, Fiorenza, Obukowicz, Mark G.

“…In mice that were alternately fasted and then refed an essential fatty acid-deficient (EFAD) diet, there was a rapid and substantial decline in tissue n-3 and…”
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Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect by Whelan, Jay, Petrik, Melissa B Hansen, McEntee, Michael F, Obukowicz, Mark G

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Lipid remodeling in mouse liver and plasma resulting from [Delta]6 fatty acid desaturase inhibition by Duffin, Kevin L, Obukowicz, Mark G, Salsgiver, William J, Welsch, Dean J, Shieh, Caroline, Raz, Amiram, Needleman, Philip

“…Electrospray/tandem mass spectrometry was used to quantify lipid remodeling in mouse liver and plasma during inhibition of polyunsaturated fatty acid synthesis…”
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Selective inhibition of [Delta]-6 desaturase impedes intestinal tumorigenesis by Hansen-Petrik, Melissa B, McEntee, Michael F, Johnson, Benjamin T, Obukowicz, Mark G, Masferrer, Jaime, Zweifel, Ben, Chiu, Chun-Hung, Whelan, Jay

“…Arachidonic acid is an important polyunsaturated fatty acid involved in cell signaling. It is derived primarily from dietary linoleic acid, and the…”
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Refold and characterization of recombinant tissue factor pathway inhibitor expressed in Escherichia coli by Diaz-Collier, J A, Palmier, M O, Kretzmer, K K, Bishop, B F, Combs, R G, Obukowicz, M G, Frazier, R B, Bild, G S, Joy, W D, Hill, S R

“…Human tissue factor pathway inhibitor (TFPI) was expressed in E. coli as a non-glycosylated protein with an additional alanine attached to the aminoterminus of…”
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Enhanced heterologous gene expression in novel rpoH mutants of Escherichia coli by OBUKOWICZ, M. G, STATEN, N. R, KRIVI, G. G

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Renaturation and purification of human tissue factor pathway inhibitor expressed in recombinant E. coli by Gustafson, M E, Junger, K D, Wun, T C, Foy, B A, Diaz-Collier, J A, Welsch, D J, Obukowicz, M G, Bishop, B F, Bild, G S, Leimgruber, R M

“…Tissue factor pathway inhibitor is an inhibitor of the extrinsic coagulation pathway. Evaluation of the pharmacological effects of tissue factor pathway…”
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Integration of the delta-endotoxin gene of Bacillus thuringiensis into the chromosome of root-colonizing strains of pseudomonads using Tn5 by Obukowicz, M G, Perlak, F J, Kusano-Kretzmer, K, Mayer, E J, Watrud, L S

“…The delta-endotoxin gene (tox) from Bacillus thuringiensis subsp. kurstaki HD-1 was cloned into Tn5 and the resulting Tn5-tox element transposed from a vector…”
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Isolation of Point Mutations in Bacteriophage Mu Attachment Regions Cloned in a λ:: Mini-Mu Phage by Burlingame, Richard P., Obukowicz, Mark G., Lynn, Debra L., Howe, Martha M.

“…Twenty-one derivatives of a λ:: mini-Mu phage containing point mutations in the Mu attachment regions were isolated after mutD mutagenesis and selection for…”
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IS50L as a non-self transposable vector used to integrate the Bacillus thuringiensis delta-endotoxin gene into the chromosome of root-colonizing pseudomonads by Obukowicz, M G, Perlak, F J, Bolten, S L, Kusano-Kretzmer, K, Mayer, E J, Watrud, L S

“…Insertion sequence IS50L of transposon Tn5 was used as a non-self transposable vector to integrate the delta-endotoxin gene (tox) from Bacillus thuringiensis…”
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Expression, purification, and in vivo activity of atrial natriuretic factor prohormone produced in Escherichia coli by Gierse, J K, Olins, P O, Devine, C S, Marlay, J D, Obukowicz, M G, Mortensen, L H, McMahon, E G, Blaine, E H, Seetharam, R

“…Atrial muscles of the heart are known to produce polypeptide hormones called atrial natriuretic factors (ANF) which have potent diuretic and hypotensive…”
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Secretion and export of IGF-1 in Escherichia coli strain JM101 by Obukowicz, M G, Turner, M A, Wong, E Y, Tacon, W C

“…The processing of LamB-IGF-1 fusion protein and the export of processed IGF-1 (insulin-like growth-factor-1) into the growth medium was examined in the…”
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