Antifungal Activity of Sodium Bicarbonate Against Fungal Agents Causing Superficial Infections

Antifungal Activity of Sodium Bicarbonate Against Fungal Agents Causing Superficial Infections

Although sodium bicarbonate—NaHCO 3 (SB) has many domestic and medical, traditional and empirical uses, only little scientific documentation of its activity is available. The aims of this study were to investigate the antifungal activity of SB on the three fungal groups (yeasts, dermatophytes and mo...

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Bibliographic Details
Published in:Mycopathologia (1975) Vol. 175; no. 1-2; pp. 153 - 158
Main Authors: Letscher-Bru, V., Obszynski, C. M., Samsoen, M., Sabou, M., Waller, J., Candolfi, E.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-02-2013
Springer
Springer Nature B.V
Subjects:
Antibacterial agents
Antifungal agents
Antifungal Agents - pharmacology
Arthrodermataceae - drug effects
Arthrodermataceae - isolation & purification
Biomedical and Life Sciences
Carbonates
Dermatomycoses - microbiology
Dextrose
Eukaryotic Microbiology
Fungal infections
Fungi
Fungi - drug effects
Fungi - isolation & purification
Glucose
Glucose metabolism
Health aspects
Humans
Infection
Life Sciences
Medical Microbiology
Microbial Ecology
Microbial Sensitivity Tests
Microbiology
Mycoses
Plant Sciences
Skin
Sodium
Sodium bicarbonate
Sodium Bicarbonate - pharmacology
Solanum tuberosum
Yeasts - drug effects
Yeasts - isolation & purification
France
Molds
Yeasts
Sodium bicarbonate
Cutaneous fungal infection
Dermatophytes
Onychomycosis
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Summary:Although sodium bicarbonate—NaHCO 3 (SB) has many domestic and medical, traditional and empirical uses, only little scientific documentation of its activity is available. The aims of this study were to investigate the antifungal activity of SB on the three fungal groups (yeasts, dermatophytes and molds) responsible for human skin and nail infections. We first evaluated the in vitro antifungal activity of SB on 70 fungal strains isolated from skin and nail infections: 40 dermatophytes, 18 yeasts and 12 molds. A concentration of 10 g/L SB inhibited the growth of 80 % of all the fungal isolates tested on Sabouraud dextrose agar. The minimal inhibitory concentration 90 (MIC90) of SB measured on Sabouraud dextrose agar, Sabouraud dextrose broth and potato dextrose broth was 5 g/L for the yeasts, 20 g/L for the dermatophytes and 40 g/L for the molds. In a second step, we prospectively evaluated the ex vivo antifungal activity of SB on 24 infected (15 dermatophytes, 7 yeasts and 2 molds) clinical specimens (15 nails and 9 skin scrapings). The fungal growth was completely inhibited for 19 (79 %) specimens and reduced for 4 (17 %) specimens after 7 days of incubation on Sabouraud dextrose–chloramphenicol agar supplemented with 10 g/L of SB as compared to Sabouraud dextrose–chloramphenicol agar without SB. In conclusion, we documented the antifungal activity of SB on the most common agents of cutaneous fungal infection and onychomycosis, and we specified the effective concentrations for the different groups of pathogenic fungi. The mechanism of action of SB has yet to be explored.
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ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-012-9583-2