Search Results - "Obrovac, Ljubica Glavaš"
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BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas
Published in International journal of molecular sciences (14-12-2023)“…Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are the most common types of cancers in the head and neck region (HNSCC)…”
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Mechanochemical synthesis and antiproliferative activity of novel ferrocene quinoline/quinolone hybrids
Published in Applied organometallic chemistry (01-07-2023)“…The synthesis of novel 1,1′‐disubstituted ferrocene conjugates appended with N‐1 and O‐4 alkylated quinolone and quinoline was reported. The target compounds…”
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Design, Synthesis, Antitumor, and Antiplasmodial Evaluation of New 7-Chloroquinoline-Benzimidazole Hybrids
Published in Molecules (Basel, Switzerland) (24-06-2024)“…Newly synthesized 7-chloro-4-aminoquinoline-benzimidazole hybrids were characterized by NMR and elemental analysis. Compounds were tested for their effects on…”
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Novel 1,2,3-Triazole-Containing Quinoline-Benzimidazole Hybrids: Synthesis, Antiproliferative Activity, In Silico ADME Predictions, and Docking
Published in Molecules (Basel, Switzerland) (01-10-2023)“…The newly synthesized quinoline-benzimidazole hybrids containing two types of triazole-methyl-phenoxy linkers were characterized via NMR and elemental…”
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Synthesis and biological evaluations of mono‐ and bis‐ferrocene uracil derivatives
Published in Applied organometallic chemistry (01-01-2021)“…Mono‐ (3a–3e and 4a–4e) and bis‐ferrocene (5a–5e and 6a–6e) conjugated 5‐substituted uracil derivatives that are bridged by 1,2,3‐triazole linker were…”
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Rhodanine Derivatives as Anticancer Agents: QSAR and Molecular Docking Studies
Published in Anti-cancer agents in medicinal chemistry (01-01-2023)“…Rhodanine derivatives have a proven wide range of biological activities. The aim of this study was to evaluate the cytotoxic effect of a series of rhodanine…”
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The Mechanism of Anti-Tumor Activity of 6-Morpholino- and 6-Amino-9-Sulfonylpurine Derivatives on Human Leukemia Cells
Published in Molecules (Basel, Switzerland) (01-08-2023)“…The aim of this study was to explore the mechanism of antitumor effect of (E)-6-morpholino-9-(styrylsulfonyl)-9H-purine (6-Morpholino-SPD) and…”
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Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations
Published in Applied organometallic chemistry (01-01-2019)“…Novel O‐alkylated quinoline and N‐alkylated 4‐quinolone derivatives attached to the ferrocene moiety through 4,1‐ (7a–d, 8a–d and 12a–d) and 1,4‐disubstituted…”
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Synthesis, Antiproliferative Evaluation and QSAR Analysis of Novel Halogen- and Amidino-Substituted Benzothiazoles and Benzimidazoles
Published in International journal of molecular sciences (13-12-2022)“…Syntheses of 6-halogen-substituted benzothiazoles were performed by condensation of 4-hydroxybenzaldehydes and 2-aminotiophenoles and subsequent O-alkylation…”
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10
HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 allele and haplotype frequencies defined by next generation sequencing in a population of East Croatia blood donors
Published in Scientific reports (26-03-2020)“…Next-generation sequencing (NGS) is increasingly used in transplantation settings, but also as a method of choice for in-depth analysis of population-specific…”
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A Facile Synthetic Approach toward Obtaining N-Doped Carbon Quantum Dots from Citric Acid and Amino Acids, and Their Application in Selective Detection of Fe(III) Ions
Published in Chemosensors (01-03-2023)“…This work reports the preparation of amino acid-functionalized CQDs from citric acid by facile hydrothermal synthesis. The prepared N-doped CQDs exhibited…”
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12
Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation
Published in Green chemistry letters and reviews (02-04-2020)“…A synthesis of two series of 3-substituted quinazolinones was performed utilizing a green chemistry approach, deep eutectic solvents and microwaves, namely…”
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13
miR-29a-3p/T-bet Regulatory Circuit Is Altered in T Cells of Patients With Hashimoto's Thyroiditis
Published in Frontiers in endocrinology (Lausanne) (24-05-2018)“…Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder that frequently evolves from asymptomatic, T-cell mediated chronic inflammation toward…”
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Altered expression of CTLA-4, CD28, VDR, and CD45 mRNA in T cells of patients with Hashimoto's thyroiditis - a pilot study
Published in Endokrynologia Polska (01-01-2017)“…CD28/T-cell receptor (TCR)/cytotoxic T-lymphocyte antigen 4 (CTLA4) complex controls T-cell tolerance and autoimmunity in Hashimoto's thyroiditis (HT). In…”
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15
Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro
Published in Acta chimica Slovenica (01-09-2019)“…In the frame of this paper, the enzyme-assisted hydrolysis coupled with ultrasound and Soxhlet extraction was applied in order to get extracts of chamomile…”
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Probing the Structural Properties of DNA/RNA Grooves with Sterically Restricted Phosphonium Dyes: Screening of Dye Cytotoxicity and Uptake
Published in ChemMedChem (01-07-2013)“…To explore in greater detail the recently reported rare kinetic differentiation between homo‐polymeric and alternating AT‐DNA sequences by using sterically…”
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The phenanthridine biguanides efficiently differentiate between dGdC, dAdT and rArU sequences by two independent, sensitive spectroscopic methods
Published in Molecular bioSystems (01-05-2011)“…At submicromolar concentrations two novel phenanthridine biguanides exhibit distinctly different spectroscopic signals for dGdC and dAdT sequences,…”
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9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase
Published in The FEBS journal (01-04-2010)“…Genetic deficiency of purine nucleoside phosphorylase (PNP; EC 2.4.2.1) activity leads to a severe selective disorder of T-cell function. Therefore, potent…”
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Synthesis and Biological Activity of Reversed Pyrimidine Nucleosides
Published in Croatica Chemica Acta (01-03-2015)“…An efficient approach to reversed nucleosides which enables their synthesis in gram quantities is described. N-1'-Pyrimidine reversed nucleosides were prepared…”
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Antiproliferative Activity of Purine Nucleoside Phosphorylase Multisubstrate Analogue Inhibitors Containing Difluoromethylene Phosphonic Acid against Leukaemia and Lymphoma Cells
Published in Chemical biology & drug design (01-04-2010)“…Potent inhibitors of purine nucleoside phosphorylase (PNP) are expected to act as selective agents against T-cell tumours. Five compounds with guanine, three…”
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