Search Results - "Obis, Èlia"

Oxidative stress and altered lipid metabolism in Friedreich ataxia by Tamarit, Jordi, Obis, Èlia, Ros, Joaquim

“…Friedreich ataxia is a genetic disease caused by the deficiency of frataxin, a mitochondrial protein. Frataxin deficiency impacts in the cell physiology at…”
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Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism by Obis, Èlia, Irazusta, Verónica, Sanchís, Daniel, Ros, Joaquim, Tamarit, Jordi

“…Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis,…”
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Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age by Jové, Mariona, Cabré, Rosanna, Mota-Martorell, Natàlia, Martin-Garí, Meritxell, Obis, Èlia, Ramos, Paula, Canales, Iván, Galo-Licona, José Daniel, Sol, Joaquim, Nogueras, Lara, Torres, Pascual, Portero-Otín, Manuel, Ayala, Victòria, Ferrer, Isidro, Pamplona, Reinald

“…Lipids are closely associated with brain structure and function. However, the potential changes in the lipidome induced by aging remain to be elucidated. In…”
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Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity by Moreno-Navarrete, José María, Jove, Mariona, Ortega, Francisco, Xifra, Gemma, Ricart, Wifredo, Obis, Èlia, Pamplona, Reinald, Portero-Otin, Manuel, Fernández-Real, José Manuel

“…Aims/hypothesis We aimed to investigate the potential mechanisms involved in the compromised adipogenesis of visceral (VAT) vs subcutaneous adipose tissue…”
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Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolome by Sol, Joaquim, Obis, Èlia, Mota‐Martorell, Natalia, Pradas, Irene, Galo‐Licona, Jose Daniel, Martin‐Garí, Meritxell, Fernández‐Bernal, Anna, Ortega‐Bravo, Marta, Mayneris‐Perxachs, Jordi, Borrás, Consuelo, Viña, José, Fuente, Mónica, Mate, Ianire, Biarnes, Carles, Pedraza, Salvador, Vilanova, Joan C., Brugada, Ramon, Ramos, Rafel, Serena, Joaquin, Ramió‐Torrentà, Lluís, Pineda, Víctor, Daunis‐I‐Estadella, Pepus, Thió‐Henestrosa, Santiago, Barretina, Jordi, Garre‐Olmo, Josep, Portero‐Otin, Manuel, Fernández‐Real, José Manuel, Puig, Josep, Jové, Mariona, Pamplona, Reinald

“…Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of “omic” techniques…”
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High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage by Berdún, Rebeca, Obis, Èlia, Mota-Martorell, Natàlia, Bassols, Anna, Valent, Daniel, Serrano, José C E, Martín-Garí, Meritxell, Rodríguez-Palmero, María, Moreno-Muñoz, José Antonio, Tibau, Joan, Quintanilla, Raquel, Pamplona, Reinald, Portero-Otín, Manuel, Jové, Mariona

“…Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein…”
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Frataxin Depletion in Yeast Triggers Up-regulation of Iron Transport Systems before Affecting Iron-Sulfur Enzyme Activities by Moreno-Cermeño, Armando, Obis, Èlia, Bellí, Gemma, Cabiscol, Elisa, Ros, Joaquim, Tamarit, Jordi

“…The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of…”
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Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex by Cabré, Rosanna, Jové, Mariona, Naudí, Alba, Ayala, Victoria, Piñol-Ripoll, Gerard, Gil-Villar, Maria P, Dominguez-Gonzalez, Mayelin, Obis, Èlia, Berdun, Rebeca, Mota-Martorell, Natalia, Portero-Otin, Manuel, Ferrer, Isidre, Pamplona, Reinald

“…Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and…”
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LIPIDS ALTERATION IN TDP-43 by Toledo, Irene García, Corchuelo, Juan Miguel Godoy, Ali, Zeinab, Jimenez-Rodriguez, Jesús, Jimenez-Coca, Irene, Fernández-Bernal, Anna, Jové, Mariona, Obis, Èlia, Matias-Guiu, Jorge, Cunningham, Thommas, Portero-Otin, Manuel, Pamplona, Reinald, Area-Gomez, Estela, Corrochano, Silvia

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Methionine transsulfuration pathway is upregulated in long-lived humans by Mota-Martorell, Natàlia, Jové, Mariona, Borrás, Consuelo, Berdún, Rebeca, Obis, Èlia, Sol, Joaquim, Cabré, Rosanna, Pradas, Irene, Galo-Licona, José Daniel, Puig, Josep, Viña, José, Pamplona, Reinald

“…Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma…”
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The Lipidome Fingerprint of Longevity by Jové, Mariona, Mota-Martorell, Natàlia, Pradas, Irene, Galo-Licona, José Daniel, Martín-Gari, Meritxell, Obis, Èlia, Sol, Joaquim, Pamplona, Reinald

“…Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings…”
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Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals by Mota-Martorell, Natalia, Jové, Mariona, Berdún, Rebeca, Òbis, Èlia, Barja, Gustavo, Pamplona, Reinald

“…Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a…”
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Ether Lipid-Mediated Antioxidant Defense in Alzheimer's Disease by Jové, Mariona, Mota-Martorell, Natàlia, Obis, Èlia, Sol, Joaquim, Martín-Garí, Meritxell, Ferrer, Isidre, Portero-Otin, Manuel, Pamplona, Reinald

“…One of the richest tissues in lipid content and diversity of the human body is the brain. The human brain is constitutively highly vulnerable to oxidative…”
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Lipid alterations in human frontal cortex in ALS‐FTLD‐TDP43 proteinopathy spectrum are partly related to peroxisome impairment by Andrés‐Benito, Pol, Gelpi, Ellen, Jové, Mariona, Mota‐Martorell, Natalia, Obis, Èlia, Portero‐Otin, Manuel, Povedano, Mònica, Pujol, Aurora, Pamplona, Reinald, Ferrer, Isidro

“…Aim Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X‐adrenoleukodystrophy…”
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Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain by Jové, Mariona, Mota-Martorell, Natàlia, Obis, Èlia, Sol, Joaquim, Martín-Garí, Meritxell, Ferrer, Isidre, Portero-Otín, Manuel, Pamplona, Reinald

“…It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical…”
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Metabolomic Profiling in Children with Celiac Disease: Beyond the Gluten-Free Diet by Martín-Masot, Rafael, Jiménez-Muñoz, María, Herrador-López, Marta, Navas-López, Víctor Manuel, Obis, Elia, Jové, Mariona, Pamplona, Reinald, Nestares, Teresa

“…Celiac disease (CD) is included in the group of complex or multifactorial diseases, i.e., those caused by the interaction of genetic and environmental factors…”
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Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides by Tamarit, Jordi, de Hoogh, Anouk, Obis, Elia, Alsina, David, Cabiscol, Elisa, Ros, Joaquim

“…Protein carbonyl detection has been commonly used to analyze the degree of damage to proteins under oxidative stress conditions. Most laboratories rely on…”
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Specific metabolomics adaptations define a differential regional vulnerability in the adult human cerebral cortex by Cabré, Rosanna, Jove, Mariona, Naudi, Alba, Ayala, Victòria, Piñol Ripoll, Gerard, Gil Villar, Maria P, Domínguez González, Mayelín, Obis, Èlia, Berdun, Rebeca, Mota-Martorell, Natalia, Portero Otin, Manuel, Ferrer, Isidro (Ferrer Abizanda), Pamplona, Reinald

“…Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and…”
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Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein by Mincheva-Tasheva, Stefka, Obis, Elia, Tamarit, Jordi, Ros, Joaquim

“…Friedreich ataxia (FRDA) is a neurodegenerative disease characterized by a decreased expression of the mitochondrial protein frataxin. Major neurological…”
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Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-x sub(L) protein by Mincheva-Tasheva, Stefka, Obis, Elia, Tamarit, Jordi, Ros, Joaquim

“…Friedreich ataxia (FRDA) is a neurodegenerative disease characterized by a decreased expression of the mitochondrial protein frataxin. Major neurological…”
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