Search Results - "Obi, Andrea"

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis by Kimball, Andrew S, Obi, Andrea T, Diaz, Jose A, Henke, Peter K

“…Venous thrombosis (VT), a leading cause of morbidity and mortality worldwide, has recently been linked to neutrophil activation and release of neutrophil…”
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Validation of the Caprini Venous Thromboembolism Risk Assessment Model in Critically Ill Surgical Patients by Obi, Andrea T, Pannucci, Christopher J, Nackashi, Andrew, Abdullah, Newaj, Alvarez, Rafael, Bahl, Vinita, Wakefield, Thomas W, Henke, Peter K

“…Appropriate risk stratification for venous thromboembolism (VTE) is essential to providing appropriate thromboprophylaxis and avoiding morbidity and mortality…”
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Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms by Davis, Frank M, Tsoi, Lam C, Melvin, William J, denDekker, Aaron, Wasikowski, Rachael, Joshi, Amrita D, Wolf, Sonya, Obi, Andrea T, Billi, Allison C, Xing, Xianying, Audu, Christopher, Moore, Bethany B, Kunkel, Steven L, Daugherty, Alan, Lu, Hong S, Gudjonsson, Johann E, Gallagher, Katherine A

“…Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA…”
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Solving the Rubik’s Cube of AAA mortality in Brazil using space-time cube analysis by Brown, Craig S, Rocha, Oscar Moreno, Obi, Andrea T

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Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing by Boniakowski, Anna E., Kimball, Andrew S., Joshi, Amrita, Schaller, Matt, Davis, Frank M., denDekker, Aaron, Obi, Andrea T, Moore, Bethany B., Kunkel, Steve L., Gallagher, Katherine A.

“…Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury. Following injury, CCR2+ monocytes are…”
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The operating room may be hazardous to your health by Smith, Margaret E., Obi, Andrea T.

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Critical Review of Mouse Models of Venous Thrombosis by Diaz, Jose A, Obi, Andrea T, Myers, Daniel D, Wrobleski, Shirley K, Henke, Peter K, Mackman, Nigel, Wakefield, Thomas W

“…Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to…”
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Calf muscle pump dysfunction and VTE risk by Obi, Andrea T., Wakefield, Thomas W.

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The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair by Kimball, Andrew S., Davis, Frank M., denDekker, Aaron, Joshi, Amrita D., Schaller, Matthew A., Bermick, Jennifer, Xing, Xianying, Burant, Charles F., Obi, Andrea T., Nysz, Dylan, Robinson, Scott, Allen, Ron, Lukacs, Nicholas W., Henke, Peter K., Gudjonsson, Johann E., Moore, Bethany B., Kunkel, Steve L., Gallagher, Katherine A.

“…Macrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined…”
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Advances in understanding the interplay between adaptive and innate immunity in experimental venous thrombus resolution by Henke, Peter K., Obi, Andrea T.

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Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing by Davis, Frank M, Schaller, Matthew A, Dendekker, Aaron, Joshi, Amrita D, Kimball, Andrew S, Evanoff, Holly, Wilke, Carol, Obi, Andrea T, Melvin, William J, Cavassani, Karen, Scola, Melissa, Carson, Beau, Moser, Stephanie, Blanc, Victoria, Engoren, Milo, Moore, Bethany B, Kunkel, Steven L, Gallagher, Katherine A

“…OBJECTIVE:Sepsis represents an acute life-threatening disorder resulting from a dysregulated host response. For patients who survive sepsis, there remains…”
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The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery by Obi, Andrea T., MD, Park, Yeo Jung, PhD, Bove, Paul, MD, Cuff, Robert, MD, Kazmers, Andris, MD, MSPH, Gurm, Hitinder S., MD, Grossman, P. Michael, MD, Henke, Peter K., MD

“…Objective Blood transfusions are common among patients undergoing major vascular surgery. Prior studies suggest an association between blood transfusion and…”
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SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism by Kumar, Nitin, Zuo, Yu, Yalavarthi, Srilakshmi, Hunker, Kristina L, Knight, Jason S, Kanthi, Yogendra, Obi, Andrea T, Ganesh, Santhi K

“…Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The…”
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Recognizing the evolving and beneficial role of regulatory T cells in aneurysm growth by Davis, Frank M., Obi, Andrea T.

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IL-4–STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock by Krempski, James, Yamani, Amnah, Thota, Lakshmi Narasimha Rao, Marella, Sahiti, Ganesan, Varsha, Sharma, Ankit, Kaneshige, Atsunori, Bai, Longchuan, Zhou, Haibin, Foster, Paul S., Wang, Shaomeng, Obi, Andrea T., Hogan, Simon P.

“…Mast cell–derived mediators induce vasodilatation and fluid extravasation, leading to cardiovascular failure in severe anaphylaxis. We previously revealed a…”
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Flow dynamics, false lumens and implications for endografting by Obi, Andrea T, Figueroa, C Alberto

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The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor by Stanger, Livia, Yamaguchi, Adriana, Yalavarthi, Pooja, Lambert, Sylviane, Gilmore, Devin, Rickenberg, Andrew, Luke, Catherine, Kumar, Kiran, Obi, Andrea T., White, Andrew, Bergh, Niklas, Dahlof, Bjorn, Holinstat, Michael

“…•CS585 is a novel prostacyclin receptor agonist that effectively inhibits integrin activation, granule secretion, and aggregation.•CS585 is a highly potent and…”
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Comparative evaluation of transcutaneous oxygen tension and ankle-brachial index as predictors of reoperation following below-knee amputation by Braet, Drew J., Pourak, Kian, Delbono, Luciano, Powell, Chloe, Smith, Margaret E., Schechtman, David, Obi, Andrea T., Coleman, Dawn M., Corriere, Matthew A.

“…Decision-making regarding level of lower extremity amputation is sometimes challenging. Selecting an appropriate anatomic level for major amputation requires…”
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SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair by Boniakowski, Anna M., denDekker, Aaron D., Davis, Frank M., Joshi, Amrita, Kimball, Andrew S., Schaller, Matthew, Allen, Ron, Bermick, Jennifer, Nycz, Dylan, Skinner, Mary E., Robinson, Scott, Obi, Andrea T., Moore, Bethany B., Gudjonsson, Johann E., Lombard, David, Kunkel, Steve L., Gallagher, Katherine A.

“…Control of inflammation is critical for the treatment of nonhealing wounds, but a delicate balance exists between early inflammation that is essential for…”
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Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients by Obi, Andrea T., Tignanelli, Christopher J., Jacobs, Benjamin N., Arya, Shipra, Park, Pauline K., Wakefield, Thomas W., Henke, Peter K., Napolitano, Lena M.

“…An association between increased venous thromboembolism (VTE) events and influenza A H1N1 (H1N1) was noted in the first 10 patients with severe acute…”
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