Search Results - "Obertas, Lidiya"

The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change by Jung, Joo Eun, Sun, Guanghua, Bautista Garrido, Jesus, Obertas, Lidiya, Mobley, Alexis S, Ting, Shun-Ming, Zhao, Xiurong, Aronowski, Jaroslaw

“…Astrocytes are an integral component of the neurovascular unit where they act as homeostatic regulators, especially after brain injuries, such as stroke. One…”
Get full text

Transplantation of Astrocytic Mitochondria Modulates Neuronal Antioxidant Defense and Neuroplasticity and Promotes Functional Recovery after Intracerebral Hemorrhage by Tashiro, Ryosuke, Bautista-Garrido, Jesus, Ozaki, Dan, Sun, Guanghua, Obertas, Lidiya, Mobley, Alexis S, Kim, Gab Seok, Aronowski, Jaroslaw, Jung, Joo Eun

“…Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions on entering adjacent cells. We recently demonstrated that these…”
Get full text

Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage by Zhao, Xiurong, Ting, Shun-Ming, Sun, Guanghua, Roy-O’Reilly, Meaghan, Mobley, Alexis S, Bautista Garrido, Jesus, Zheng, Xueping, Obertas, Lidiya, Jung, Joo Eun, Kruzel, Marian, Aronowski, Jaroslaw

“…BACKGROUND AND PURPOSE—Intracerebral hemorrhage (ICH) is a devastating disease with a 30-day mortality of ~50%. There are no effective therapies for ICH. ICH…”
Get full text

Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement by Tashiro, Ryosuke, Ozaki, Dan, Bautista-Garrido, Jesus, Sun, Guanghua, Obertas, Lidiya, Mobley, Alexis S, Kim, Gab Seok, Aronowski, Jaroslaw, Jung, Joo Eun

“…Aging drives cognitive decline, and mitochondrial dysfunction is a hallmark of age-induced neurodegeneration. Recently, we demonstrated that astrocytes secrete…”
Get full text

Abstract 16: Retinoid X Receptors (RXR) Play Essential Roles In Improving Post-ischemic Stroke Recovery In Aged Brain By Restoring Age-associated Dysfunctions Of Microglia/macrophages by Ting, Shun-Ming, Sun, Guanghua, Obertas, Lidiya, Aronowski, Jaroslaw A

“…After stroke, microglia and blood macrophages (MΦ) clear dead cells and cellular debris in the infarcted brain through phagocytosis. However, the phagocytic…”
Get full text

Brain Cleanup as a Potential Target for Poststroke Recovery: The Role of RXR (Retinoic X Receptor) in Phagocytes by Ting, Shun-Ming, Zhao, Xiurong, Sun, Guanghua, Obertas, Lidiya, Ricote, Mercedes, Aronowski, Jaroslaw

“…BACKGROUND AND PURPOSE—Phagocytic cells, such as microglia and blood-derived macrophages, are a key biological modality responsible for phagocytosis-mediated…”
Get full text

Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91 by Zhao, Xiurong, Ting, Shun-Ming, Sun, Guanghua, Bautista Garrido, Jesus, Obertas, Lidiya, Aronowski, Jaroslaw

“…Within hours after intracerebral hemorrhage (ICH) onset, masses of polymorphonuclear neutrophils (PMNs) infiltrate the ICH-affected brain. After degranulation…”
Get full text

Grail controls Th2 cell development by targeting STAT6 for degradation by Sahoo, Anupama, Alekseev, Andrei, Obertas, Lidiya, Nurieva, Roza

“…T helper (Th)-2 cells are the major players in allergic asthma; however, the mechanisms that control Th2-mediated inflammation are poorly understood. Here we…”
Get full text

Batf is important for IL-4 expression in T follicular helper cells by Sahoo, Anupama, Alekseev, Andrei, Tanaka, Kentaro, Obertas, Lidiya, Lerman, Beatrisa, Haymaker, Cara, Clise-Dwyer, Karen, McMurray, John S., Nurieva, Roza

“…Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral…”
Get full text

Brain cleanup as a potential target for post-stroke recovery: the role of RXR in phagocytes by Ting, Shun-Ming, Zhao, Xiurong, Sun, Guanghua, Obertas, Lidiya, Ricote, Mercedes, Aronowski, Jaroslaw

Get full text

Abstract TP345: Humanin, a Mitochondria-Derived Peptide Improves Outcome After Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change by Jung, Joo Eun, Sun, Guanghua, Garrido, Jesus Bautista, Obertas, Lidiya, Mobley, Alexis S, Ting, Shun-Ming, Zhao, Xiurong, Aronowski, Jaroslaw

“…Abstract only Background and Purpose: Astrocytes are the integral components of neurovascular unit where they act as homeostatic regulator, including after…”
Get full text

Abstract P433: Multipotent Adult Progenitor Cells as a Highly Promising Therapy for Treatment of Intracerebral Hemorrhage by Zhao, Xiurong, Obertas, Lidiya, Sun, Guanghua, Ting, Shun Ming, Goh, Andrew, Savitz, Sean, Busch, Sarah, Bogaerts, Annelies, Mays, Robert W, Aronowski, Jaroslaw A

“…BackgroundMultipotent adult progenitor cells (MAPC) are an adherent adult stem cell being evaluated as a treatment for ischemic stroke in humans under the name…”
Get full text

Abstract 182: Rxrα in Microglia Acts as Central Player in the Cleanup and Repair After Ischemic Stroke by Ting, Shun-Ming, Zhao, Xiurong, Sun, Guanghua, Garrido, Juan J, Obertas, Lidiya, Aronowski, Jaroslaw

“…Abstract only Microglia/macrophage (MΦ) are immune response cells with function in clearing cell debris and tissue repair after ischemic brain damage. Retinoid…”
Get full text

Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial by Morais, Andreia, Locascio, Joseph J., Sansing, Lauren H., Lamb, Jessica, Nagarkatti, Karisma, Imai, Takahiko, van Leyen, Klaus, Aronowski, Jaroslaw, Koenig, James I., Bosetti, Francesca, Lyden, Patrick, Ayata, Cenk

“…The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to…”
Get full text