Search Results - "Oberstein, Adam"

Subconfluent ARPE-19 Cells Display Mesenchymal Cell-State Characteristics and Behave like Fibroblasts, Rather Than Epithelial Cells, in Experimental HCMV Infection Studies by Golconda, Preethi, Andrade-Medina, Mariana, Oberstein, Adam

“…Human cytomegalovirus (HCMV) has a broad cellular tropism and epithelial cells are important physiological targets during infection. The retinal pigment…”
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Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology by Park, Jihye, Gill, Kevin Sean, Aghajani, Ali Asghar, Heredia, Jeremiah Dallas, Choi, Hannah, Oberstein, Adam, Procko, Erik

“…A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate…”
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Human cytomegalovirus pUL97 kinase induces global changes in the infected cell phosphoproteome by Oberstein, Adam, Perlman, David H., Shenk, Thomas, Terry, Laura J.

“…Replication of human cytomegalovirus (HCMV) is regulated in part by cellular kinases and the single viral Ser/Thr kinase, pUL97. The virus‐coded kinase…”
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A tumor-specific endogenous repetitive element is induced by herpesviruses by Nogalski, Maciej T., Solovyov, Alexander, Kulkarni, Anupriya S., Desai, Niyati, Oberstein, Adam, Levine, Arnold J., Ting, David T., Shenk, Thomas, Greenbaum, Benjamin D.

“…Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and…”
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Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry by Shi, Yigong, Wu, Zhuoru, Yan, Nieng, Feng, Liang, Oberstein, Adam, Yan, Hanchi, Baker, Rosanna P, Gu, Lichuan, Jeffrey, Philip D, Urban, Sinisa

“…Intramembrane proteolysis regulates diverse biological processes. Cleavage of substrate peptide bonds within the membrane bilayer is catalyzed by integral…”
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role of binding site cluster strength in Bicoid-dependent patterning in Drosophila by Ochoa-Espinosa, A, Yucel, G, Kaplan, L, Pare, A, Pura, N, Oberstein, A, Papatsenko, D, Small, S

“…The maternal morphogen Bicoid (Bcd) is distributed in an embryonic gradient that is critical for patterning the anterior-posterior (AP) body plan in…”
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Site-specific transgenesis by Cre-mediated recombination in Drosophila by Small, Stephen, Oberstein, Adam, Pare, Adam, Kaplan, Leah

“…Transposons such as P elements are routinely used to stably transfer exogenous DNA (transgenes) into the Drosophila genome. Transgene insertion events,…”
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Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype by Oberstein, Adam, Shenk, Thomas

“…Human cytomegalovirus (HCMV) is the prototypical human β-herpes virus. Here we perform a systems analysis of the HCMV host-cell transcriptome, using gene set…”
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Groucho-dependent repression by Sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo by Andrioli, Luiz P., Oberstein, Adam L., Corado, Maria S.G., Yu, Danyang, Small, Stephen

“…The Drosophila body plan is composed of a linear array of cephalic, thoracic, and abdominal segments along the anterior posterior axis. The number and…”
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Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms by Andrioli, Luiz Paulo Moura, Vasisht, Vikram, Theodosopoulou, Ekaterina, Oberstein, Adam, Small, Stephen

“…The striped expression pattern of the pair-rule gene even skipped ( eve ) is established by five stripe-specific enhancers, each of which responds in a unique…”
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Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts by Wu, Kai, Oberstein, Adam, Wang, Wei, Shenk, Thomas

“…Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein complexes: a trimeric complex (gH/gL/gO) that facilitates viral…”
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Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex by Oberstein, Adam, Jeffrey, Philip D., Shi, Yigong

“…Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to…”
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Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex: BECLIN 1 IS A NOVEL BH3-ONLY PROTEIN by Oberstein, Adam, Jeffrey, Philip D, Shi, Yigong

“…Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to…”
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Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity by Mathias, Rommel A., Greco, Todd M., Oberstein, Adam, Budayeva, Hanna G., Chakrabarti, Rumela, Rowland, Elizabeth A., Kang, Yibin, Shenk, Thomas, Cristea, Ileana M.

“…Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and…”
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Crystal Structure of the Bcl-X sub(L)-Beclin 1 Peptide Complex: BECLIN 1 IS A NOVEL BH3-ONLY PROTEIN by Oberstein, Adam, Jeffrey, Philip D, Shi, Yigong

“…Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to…”
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Structural and functional analysis of the autophagy protein Beclin-1 by Oberstein, Adam

“…Autophagy is a conserved cellular response which serves to recycle macromolecules during nutrient limitation. In mammals, it involves the sequestration of…”
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