Search Results - "Obermeyer, Allie C"

Phase Separation Behavior of Supercharged Proteins and Polyelectrolytes by Cummings, Chad S, Obermeyer, Allie C

“…Membraneless organelles, like membrane-bound organelles, are essential to cell homeostasis and provide discrete cellular subcompartments. Unlike classical…”
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Ionic polypeptide tags for protein phase separation by Kapelner, Rachel A, Obermeyer, Allie C

“…Polyelectrolytes of opposite charge in aqueous solution can undergo a liquid-liquid phase separation known as complex coacervation. Complex coacervation of…”
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Genetic and Covalent Protein Modification Strategies to Facilitate Intracellular Delivery by Horn, Justin M, Obermeyer, Allie C

“…Protein-based therapeutics represent a rapidly growing segment of approved disease treatments. Successful intracellular delivery of proteins is an important…”
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Synthesis and Application of Protein-Containing Block Copolymers by Obermeyer, Allie C, Olsen, Bradley D

“…Proteins possess an impressive array of functionality ranging from catalytic activity to selective binding and mechanical strength, making them highly…”
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Intracellular phase separation of globular proteins facilitated by short cationic peptides by Yeong, Vivian, Wang, Jou-wen, Horn, Justin M., Obermeyer, Allie C.

“…Phase separation provides intracellular organization and underlies a variety of cellular processes. These biomolecular condensates exhibit distinct physical…”
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Macro- and Microphase Separated Protein-Polyelectrolyte Complexes: Design Parameters and Current Progress by Horn, Justin M, Kapelner, Rachel A, Obermeyer, Allie C

“…Protein-containing polyelectrolyte complexes (PECs) are a diverse class of materials, composed of two or more oppositely charged polyelectrolytes that condense…”
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Oxidative Modification of Native Protein Residues Using Cerium(IV) Ammonium Nitrate by Seim, Kristen L, Obermeyer, Allie C, Francis, Matthew B

“…A new protein modification strategy has been developed that is based on an oxidative coupling reaction that targets electron-rich amino acids. This strategy…”
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Selectivity of Complex Coacervation in Multiprotein Mixtures by Ahn, So Yeon, Obermeyer, Allie C.

“…Liquid–liquid phase separation of biomolecules is increasingly recognized as being relevant to various cellular functions, and complex coacervation of…”
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Three‐Dimensional Ordered Antibody Arrays Through Self‐Assembly of Antibody–Polymer Conjugates by Dong, Xue‐Hui, Obermeyer, Allie C., Olsen, Bradley D.

“…Three‐dimensional (3D) ordered arrays of human immunoglobulin G (IgG) were fabricated using well‐defined full‐length antibody–polymer conjugates (APCs). The…”
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Designing negative feedback loops in enzymatic coacervate droplets by Modi, Nisha, Chen, Siwei, Adjei, Imelda N. A, Franco, Briana L, Bishop, Kyle J. M, Obermeyer, Allie C

“…Membraneless organelles within the living cell use phase separation of biomolecules coupled with enzymatic reactions to regulate cellular processes. The…”
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Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics by Yeong, Vivian, Werth, Emily G, Brown, Lewis M, Obermeyer, Allie C

“…While eukaryotic cells have a myriad of membrane-bound organelles enabling the isolation of different chemical environments, prokaryotic cells lack these…”
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Photoactivated Bioconjugation Between ortho-Azidophenols and Anilines: A Facile Approach to Biomolecular Photopatterning by El Muslemany, Kareem M, Twite, Amy A, ElSohly, Adel M, Obermeyer, Allie C, Mathies, Richard A, Francis, Matthew B

“…Methods for the surface patterning of small molecules and biomolecules can yield useful platforms for drug screening, synthetic biology applications,…”
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Multivalent viral capsids with internal cargo for fibrin imaging by Obermeyer, Allie C, Capehart, Stacy L, Jarman, John B, Francis, Matthew B

“…Thrombosis is the cause of many cardiovascular syndromes and is a significant contributor to life-threatening diseases, such as myocardial infarction and…”
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Giving the green light by Liao, Jane, Obermeyer, Allie C.

“…Jane Liao and Allie C. Obermeyer explore the discovery, modification and applications of green fluorescent protein, best known for its use as a tool to cast…”
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Viscoelasticity of globular protein-based biomolecular condensates by Fisher, Rachel S., Obermeyer, Allie C.

“…The phase separation of biomolecules into biomolecular condensates has emerged as a ubiquitous cellular process. Understanding how intrinsically disordered…”
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Investigating Fundamental Principles of Nonequilibrium Assembly Using Temperature-Sensitive Copolymers by Chittari, Supraja S., Obermeyer, Allie C., Knight, Abigail S.

“…Both natural biomaterials and synthetic materials benefit from complex energy landscapes that provide the foundation for structure–function relationships and…”
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Charge-Patterned Disordered Peptides Tune Intracellular Phase Separation in Bacteria by Liao, Jane, Yeong, Vivian, Obermeyer, Allie C.

“…Subcellular phase-separated compartments, known as biomolecular condensates, play an important role in the spatiotemporal organization of cells. To understand…”
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N‑Terminal Modification of Proteins with o‑Aminophenols by Obermeyer, Allie C, Jarman, John B, Francis, Matthew B

“…The synthetic modification of proteins plays an important role in chemical biology and biomaterials science. These fields provide a constant need for chemical…”
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Self-assembly of globular proteins with intrinsically disordered protein polyelectrolytes and block copolymers by Horn, Justin M, Zhu, Yuncan, Ahn, So Yeon, Obermeyer, Allie C

“…Intrinsically disordered polypeptides are a versatile class of materials, combining the biocompatibility of peptides with the disordered structure and diverse…”
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Complex coacervation of supercharged proteins with polyelectrolytes by Obermeyer, Allie C, Mills, Carolyn E, Dong, Xue-Hui, Flores, Romeo J, Olsen, Bradley D

“…Complexation of proteins with polyelectrolytes or block copolymers can lead to phase separation to generate a coacervate phase or self-assembly of coacervate…”
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