Search Results - "Oberlender, Robert"

Synthesis and evaluation of 2,3-dihydrobenzofuran analogs of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane: drug discrimination studies in rats by Nichols, David E, Hoffman, Andrew J, Oberlender, Robert A, Riggs, Robert M

“…Two analogues, 6-(2-aminopropyl)-5-methoxy-2,3-dihydrobenzofuran and 6-(2-aminopropyl)-5-methoxy-2-methyl-2,3-dihydrobenzofuran, of the hallucinogenic agent…”
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Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2,5-dimethoxy-4-(2-butyl)phenyl]-2-aminopropane and 1-[2,5-dimethoxy-4-(2-methylpropyl)phenyl]-2-aminopropane by Oberlender, Robert A, Kothari, Paresh J, Nichols, David E, Zabik, Joseph E

“…Two novel hallucinogen analogues related to 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM, STP) were synthesized and evaluated in the two-lever drug…”
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Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogs of hallucinogenic phenethylamines: lack of LSD-like biological activity by Nichols, David E, Jadhav, Kiran P, Oberlender, Robert A, Zabik, Joseph E, Bossart, Josef F, Hamada, Akihiko, Miller, Duane D

“…cis- and trans-2-(2,4,5-trimethoxyphenyl)cyclobutylamine and trans-2-(2,5-dimethoxy-4-methylphenyl)cyclobutylamine were synthesized as conformationally…”
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Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class by Nichols, David E, Hoffman, Andrew J, Oberlender, Robert A, Jacob, Peyton, Shulgin, Alexander T

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Drug discrimination studies with MDMA and amphetamine by OBERLENDER, R, NICHOLS, D. E

“…The term entactogen has recently been introduced to describe a new pharmacological class of compounds best represented by 3,4-methylenedioxymethamphetamine,…”
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Structure-activity relationships of MDMA and related compounds: a new class of psychoactive drugs? by Nichols, D E, Oberlender, R

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Nonneurotoxic tetralin and indan analogs of 3,4-(methylenedioxy)amphetamine (MDA) by Nichols, David E, Brewster, William K, Johnson, Michael P, Oberlender, Robert, Riggs, Robert M

“…Four cyclic analogues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied. These congeners, 5,6- and…”
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Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA) by Johnson, Michael P, Frescas, Stewart P, Oberlender, Robert, Nichols, David E

“…The racemate and the enantiomers of 1-(3-methoxy-4-methyphenyl)-2- aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus…”
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The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: An in vivo microdialysis study by Kurata, Kenichi, Ashby Jr, Charles R., Oberlender, Robert, Tanii, Yasuyuki, Kurachi, Masayoshi, Rini, Nancy J., Strecker, Robert E.

“…In this study, we examined the effect of n‐methylquipazine (NMQ), which is a putative 5‐hydroxytryptamine, (5‐HT3) receptor agonist, on the extracellular…”
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2,3-Dihydrobenzofuran analogs of hallucinogenic phenethylamines by Nichols, David E, Snyder, Scott E, Oberlender, Robert, Johnson, Michael P, Huang, Xuemei

“…Two 2,3-dihydrobenzofuran analogues of hallucinogenic amphetamines were prepared and evaluated for activity in the two-lever drug-discrimination paradigm in…”
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Structural variation and (+)-amphetamine-like discriminative stimulus properties by Oberlender, R, Nichols, D E

“…Rats were trained to discriminate (+)-amphetamine sulfate (5.43 mumol/kg, 1 mg/kg) from saline in a food-reinforced, two-lever drug discrimination paradigm…”
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Effect of a Chiral 4-Alkyl Substituent in Hallucinogenic Amphetamines by Oberlender, Robert, Ramachandran, P. V, Johnson, Michael P, Huang, Xuemei, Nichols, David E

“…The potency of hallucinogenic amphetamine derivatives of the 1-(2,5-dimethoxy-4-alkylphenyl)-2-aminopropane type drops dramatically when the length of the…”
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Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane by OBERLENDER, R, PFAFF, R. C, JOHNSON, M. P, XUEMEI HUANG, NICHOLS, D. E

“…The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In rats trained…”
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5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine by Nichols, D E, Johnson, M P, Oberlender, R

“…A rigid analogue, 5-iodo-2-aminoindan (5-IAI), of the serotonin neurotoxic halogenated amphetamine p-iodoamphetamine (PIA) was pharmacologically evaluated for…”
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Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine by Johnson, M P, Huang, X M, Oberlender, R, Nash, J F, Nichols, D E

“…The present set of experiments was designed to examine the effects of extension of the alpha-methyl of p-chloroamphetamine (PCA) to an alpha-ethyl. Therefore,…”
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Stereoselective aspects of hallucinogenic drug action and drug discrimination studies of entactogens by Oberlender, Robert Arthur

“…Stereochemical aspects of the structure-activity relationships of hallucinogenic drugs were explored through the asymmetric syntheses and pharmacological…”
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Stereoselective LSD-like activity in d-lysergic acid amides of R- and S-2-aminobutane by Oberlender, Robert, Pfaff, Robert C, Johnson, Michael P, Huang, Xuemei, Nichols, David E

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Tomoxetine and the stereoselectivity of drug action by Oberlender, R, Nichols, D E, Ramachandran, P V, Srebnik, M

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Unreliability of the rat stomach fundus as a predictor of hallucinogenic activity in substituted phenethylamines by Nichols, D E, Schooler, D, Yeung, M C, Oberlender, R A, Zabik, J E

“…A series of three isomeric 2,4,5-substituted monoethoxy dimethoxy phenylisopropylamines were compared for their contractile effect in the rat fundus as…”
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