Search Results - "Oberhauser, Thomas"
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The Synthetic-Technical Development of Oseltamivir Phosphate Tamiflu™: A Race against Time
Published in Chimia (28-03-2007)“…The clinical development of the first orally available neuraminidase inhibitor prodrug oseltamivir phosphate (Tamiflu™) proceeded very fast. In order to…”
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Industrial Synthesis of the Key Precursor in the Synthesis of the Anti-Influenza Drug Oseltamivir Phosphate (Ro 64-0796/002, GS-4104-02): Ethyl (3R,4S,5S)-4,5-epoxy-3-(1-ethyl-propoxy)-cyclohex-1-ene-1-carboxylate
Published in Organic process research & development (01-07-1999)“…Starting from (−)-quinic acid, the title compound was synthesized in seven chemical steps and an overall yield of 35−38%. The route of the improved Gilead…”
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A New Bromination Method for Phenols and Anisoles: NBS/HBF4·Et2O in CH3CN
Published in Journal of organic chemistry (27-06-1997)Get full text
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A New Bromination Method for Phenols and Anisoles: NBS/HBF 4 ·Et 2 O in CH 3 CN
Published in Journal of organic chemistry (01-06-1997)Get full text
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Novel Hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4-c]pyrroles]: Highly Selective Small-Molecule Nociceptin/Orphanin FQ Receptor Agonists
Published in Journal of medicinal chemistry (16-01-2003)“…Novel hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4-c]pyrroles that act as potent and selective orphanin FQ/nociceptin (N/OFQ) receptor (NOP) agonists were…”
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A New Bromination Method for Phenols and Anisoles: NBS/HBF(4).Et(2)O in CH(3)CN
Published in Journal of organic chemistry (27-06-1997)Get full text
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7
On the stereochemical purity of (+)-7-aminocephalosporanic acid
Published in Tetrahedron (27-05-1996)“…(±)-7-Aminocephalosporanic acid ( 18a) and (±)-7- epi-aminocephalosporanic acid ( 4a) have been synthesized. A chiral HPLC method has been developed for the…”
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