Search Results - "Oberg, Kerby C"

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer by Chirshev, Evgeny, Oberg, Kerby C., Ioffe, Yevgeniya J., Unternaehrer, Juli J.

“…Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let - 7 (MIRLET7) family controls…”
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Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing by Fu, Ya-Wen, Dai, Xin-Yue, Wang, Wen-Tian, Yang, Zhi-Xue, Zhao, Juan-Juan, Zhang, Jian-Ping, Wen, Wei, Zhang, Feng, Oberg, Kerby C, Zhang, Lei, Cheng, Tao, Zhang, Xiao-Bing

“…Abstract Investigations of CRISPR gene knockout editing profiles have contributed to enhanced precision of editing outcomes. However, for homology-directed…”
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Review of the Molecular Development of the Thumb: Digit Primera by Oberg, Kerby C.

“…Background The thumb, or digit 1, is not a typical digit. In addition to its unusual mobility and function, its formation is also unusual. It is the last digit…”
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Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity by Castilla-Ibeas, Alejandro, Zdral, Sofía, Galán, Laura, Haro, Endika, Allou, Lila, Campa, Víctor M., Icardo, Jose M., Mundlos, Stefan, Oberg, Kerby C., Ros, Marian A.

“…Mammalian digit tip regeneration is linked to the presence of nail tissue, but a nail-explicit model is missing. Here, we report that nail-less double-ventral…”
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Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development by Haro, Endika, Delgado, Irene, Junco, Marisa, Yamada, Yoshihiko, Mansouri, Ahmed, Oberg, Kerby C, Ros, Marian A

“…The formation and maintenance of the apical ectodermal ridge (AER) is critical for the outgrowth and patterning of the vertebrate limb. The induction of the…”
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Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome pathogenicity by Haro, Endika, Petit, Florence, Pira, Charmaine U., Spady, Conor D., Lucas-Toca, Sara, Yorozuya, Lauren I., Gray, Austin L., Escande, Fabienne, Jourdain, Anne-Sophie, Nguyen, Andy, Fellmann, Florence, Good, Jean-Marc, Francannet, Christine, Manouvrier-Hanu, Sylvie, Ros, Marian A., Oberg, Kerby C.

“…LMX1B haploinsufficiency causes Nail-patella syndrome (NPS; MIM 161200), characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease,…”
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Developmental Biology and Classification of Congenital Anomalies of the Hand and Upper Extremity by Oberg, Kerby C., MD, PhD, Feenstra, Jennifer M., BS, Manske, Paul R., MD, Tonkin, Michael A., MD

“…Recent investigations into the mechanism of limb development have clarified the roles of several molecules, their pathways, and interactions. Characterization…”
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Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis by Chirshev, Evgeny, Hojo, Nozomi, Bertucci, Antonella, Sanderman, Linda, Nguyen, Anthony, Wang, Hanmin, Suzuki, Tise, Brito, Emmanuel, Martinez, Shannalee R., Castañón, Christine, Mirshahidi, Saied, Vazquez, Marcelo E., Wat, Pamela, Oberg, Kerby C., Ioffe, Yevgeniya J., Unternaehrer, Juli J.

“…We studied ovarian cancer patient‐derived cells to determine their epithelial vs. mesenchymal phenotype, and their stemness, migration, invasion, and tumor…”
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Lmx1b-targeted cis -regulatory modules involved in limb dorsalization by Haro, Endika, Watson, Billy A, Feenstra, Jennifer M, Tegeler, Luke, Pira, Charmaine U, Mohan, Subburaman, Oberg, Kerby C

“…Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal…”
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Classification of Congenital Anomalies of the Hand and Upper Limb: Development and Assessment of a New System by Tonkin, Michael A., MD, Tolerton, Sarah K., MBBS, Quick, Tom J., MA, Harvey, Isaac, MBBS, Lawson, Richard D., MBBS, Smith, Nicholas C., MBBS, Oberg, Kerby C., MD, PhD

“…The Oberg, Manske, and Tonkin (OMT) classification of congenital hand and upper limb anomalies was proposed in 2010 as a replacement for the Swanson…”
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Sox, Fox, and Lmx1b binding sites differentially regulate a Gdf5-Associated regulatory region during elbow development by Yeboah, Ruth-Love, Pira, Charmaine U, Shankel, Matthew, Cooper, Allen M, Haro, Endika, Ly, Van-Dai, Wysong, Kenrick, Zhang, Michael, Sandoval, Nicole, Oberg, Kerby C

“…The articulating ends of limb bones have precise morphology and asymmetry that ensures proper joint function. Growth differentiation factor 5 (Gdf5) is a…”
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Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias by Magaki, Shino, Raghavan, Ravi, Mueller, Claudius, Oberg, Kerby C., Vinters, Harry V., Kirsch, Wolff M.

“…Accumulating evidence implicates a role for altered iron and copper metabolism in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease…”
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CORR Insights®: Is EDTA Irrigation Effective in Reducing Bacterial Infection in a Rat Model of Contaminated Intra-articular Implants? by Oberg, Kerby C.

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Detection of genes regulated by Lmx1b during limb dorsalization by Feenstra, Jennifer M., Kanaya, Kohei, Pira, Charmaine U., Hoffman, Sarah E., Eppey, Richard J., Oberg, Kerby C.

“…Lmx1b is a homeodomain transcription factor that regulates dorsal identity during limb development. Lmx1b knockout (KO) mice develop distal ventral–ventral…”
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Classification of congenital upper limb anomalies: towards improved communication, diagnosis, and discovery by Oberg, Kerby C.

“…Recently the International Federation of Societies for Surgery of the Hand replaced the Swanson scheme for classifying congenital upper limb anomalies with the…”
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Necrotizing fasciitis: a fourteen-year retrospective study of 163 consecutive patients by Childers, Ben J, Potyondy, Louis D, Nachreiner, Ryan, Rogers, Frank R, Childers, Ellyn R, Oberg, Kerby C, Hendricks, Douglas L, Hardesty, Robert A

“…This review was prompted by continued public and professional interest of necrotizing fasciitis as well as worldwide increases in the incidence of…”
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Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome by Chen, Haixu, Lun, Yi, Ovchinnikov, Dmitry, Kokubo, Hiroki, Oberg, Kerby C, Pepicelli, Carmen V, Can, Lin, Lee, Brendan, Johnson, Randy L

“…Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally…”
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The Oberg-Manske-Tonkin (OMT) Classification of Congenital Upper Extremities: Update for 2020 by Goldfarb, Charles A., Ezaki, Marybeth, Wall, Lindley B., Lam, Wee L., Oberg, Kerby C.

“…A new classification for congenital upper-extremity anomalies was first published in 2010. It has come to be known as the OMT classification highlighting the…”
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An E‐Box Binding Site is Sufficient for ZPA Regulatory Sequence (ZRS) Activity in the Limb by Ball, Kathryn F., Pira, Charmaine U., Oberg, Kerby C.

“…The zone of polarizing activity (ZPA) is a cluster of mesodermal cells that secrete Sonic hedgehog (Shh) to regulate anterior‐posterior patterning during limb…”
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The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration by Castilla-Ibeas, Alejandro, Zdral, Sofía, Oberg, Kerby C, Ros, Marian A

“…The limb anatomy displays well-defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb…”
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