Search Results - "Obenauf, Anna C."

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer by Bindea, Gabriela, Mlecnik, Bernhard, Tosolini, Marie, Kirilovsky, Amos, Waldner, Maximilian, Obenauf, Anna C., Angell, Helen, Fredriksen, Tessa, Lafontaine, Lucie, Berger, Anne, Bruneval, Patrick, Fridman, Wolf Herman, Becker, Christoph, Pagès, Franck, Speicher, Michael R., Trajanoski, Zlatko, Galon, Jérôme

“…The complex interactions between tumors and their microenvironment remain to be elucidated. Combining large-scale approaches, we examined the spatio-temporal…”
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Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment by Haas, Lisa, Obenauf, Anna C

“…For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was…”
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Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis by Valiente, Manuel, Obenauf, Anna C., Jin, Xin, Chen, Qing, Zhang, Xiang H.-F., Lee, Derek J., Chaft, Jamie E., Kris, Mark G., Huse, Jason T., Brogi, Edi, Massagué, Joan

“…Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the brain die of unknown causes. Here, we identify plasmin from…”
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SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis by Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J, Herzog, Veronika A, Reichholf, Brian, Cisneros, David A, Hoffmann, Thomas, Schlapansky, Moritz F, Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C, Popow, Johannes, Ameres, Stefan L, Zuber, Johannes

“…Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. We combined SLAM-seq…”
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The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis by Mlecnik, Bernhard, Bindea, Gabriela, Kirilovsky, Amos, Angell, Helen K, Obenauf, Anna C, Tosolini, Marie, Church, Sarah E, Maby, Pauline, Vasaturo, Angela, Angelova, Mihaela, Fredriksen, Tessa, Mauger, Stéphanie, Waldner, Maximilian, Berger, Anne, Speicher, Michael R, Pagès, Franck, Valge-Archer, Viia, Galon, Jérôme

“…Although distant metastases account for most of the deaths in cancer patients, fundamental questions regarding mechanisms that promote or inhibit metastasis…”
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Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters by Umkehrer, Christian, Holstein, Felix, Formenti, Laura, Jude, Julian, Froussios, Kimon, Neumann, Tobias, Cronin, Shona M., Haas, Lisa, Lipp, Jesse J., Burkard, Thomas R., Fellner, Michaela, Wiesner, Thomas, Zuber, Johannes, Obenauf, Anna C.

“…We developed a functional lineage tracing tool termed CaTCH (CRISPRa tracing of clones in heterogeneous cell populations). CaTCH combines precise clonal…”
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Germline mutations in BAP1 predispose to melanocytic tumors by Wiesner, Thomas, Bastian, Boris C, Speicher, Michael R, Obenauf, Anna C, Murali, Rajmohan, Fried, Isabella, Griewank, Klaus G, Ulz, Peter, Windpassinger, Christian, Wackernagel, Werner, Loy, Shea, Wolf, Ingrid, Viale, Agnes, Lash, Alex E, Pirun, Mono, Socci, Nicholas D, Rütten, Arno, Palmedo, Gabriele, Abramson, David, Offit, Kenneth, Ott, Arthur, Becker, Jürgen C, Cerroni, Lorenzo, Kutzner, Heinz

“…Common acquired melanocytic nevi are benign neoplasms that are composed of small, uniform melanocytes and are typically present as flat or slightly elevated…”
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Alternative transcription initiation leads to expression of a novel ALK isoform in cancer by Wiesner, Thomas, Lee, William, Obenauf, Anna C., Ran, Leili, Murali, Rajmohan, Zhang, Qi Fan, Wong, Elissa W. P., Hu, Wenhuo, Scott, Sasinya N., Shah, Ronak H., Landa, Iñigo, Button, Julia, Lailler, Nathalie, Sboner, Andrea, Gao, Dong, Murphy, Devan A., Cao, Zhen, Shukla, Shipra, Hollmann, Travis J., Wang, Lu, Borsu, Laetitia, Merghoub, Taha, Schwartz, Gary K., Postow, Michael A., Ariyan, Charlotte E., Fagin, James A., Zheng, Deyou, Ladanyi, Marc, Busam, Klaus J., Berger, Michael F., Chen, Yu, Chi, Ping

“…A novel ALK transcript expressed in a subset of human cancers, arising from a de novo alternative transcription initiation site within the ALK gene, is…”
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LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma by Leiendecker, Lukas, Jung, Pauline S, Krecioch, Izabela, Neumann, Tobias, Schleiffer, Alexander, Mechtler, Karl, Wiesner, Thomas, Obenauf, Anna C

“…Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies…”
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Metastatic colonization by circulating tumour cells by Massagué, Joan, Obenauf, Anna C.

“…Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through…”
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Humanized large-scale expanded endothelial colony–forming cells function in vitro and in vivo by Reinisch, Andreas, Hofmann, Nicole A., Obenauf, Anna C., Kashofer, Karl, Rohde, Eva, Schallmoser, Katharina, Flicker, Karin, Lanzer, Gerhard, Linkesch, Werner, Speicher, Michael R., Strunk, Dirk

“…Endothelial progenitor cells are critically involved in essential biologic processes, such as vascular homeostasis, regeneration, and tumor angiogenesis…”
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Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions by SCHALLMOSER, Katharina, BARTMANN, Christina, WAGNER, Wolfgang, ROHDE, Eva, BORK, Simone, GUELLY, Christian, OBENAUF, Anna C, REINISCH, Andreas, HORN, Patrick, HO, Anthony D, STRUNK, Dirk

“…Research on mesenchymal stromal cells has created high expectations for a variety of therapeutic applications. Extensive propagation to yield enough…”
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p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice by Speicher, Michael R, Schlaudraff, Falk, Peit, Elvira, Clevers, Hans, Lechel, André, Danenberg, Esther, Begus-Nahrmann, Yvonne, Nalapareddy, Kodandaramireddy, Liss, Birgit, Kestler, Hans, Rudolph, K Lenhard, Hoffmann, Eva, Schirmacher, Peter, Obenauf, Anna C, Barker, Nick

“…Telomere dysfunction limits the proliferative capacity of human cells and induces organismal aging by activation of p53 and p21 (refs. 1, 2, 3, 4, 5, 6)…”
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Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum by Schallmoser, Katharina, Rohde, Eva, Reinisch, Andreas, Bartmann, Christina, Thaler, Daniela, Drexler, Camilla, Obenauf, Anna C, Lanzer, Gerhard, Linkesch, Werner, Strunk, Dirk

“…Adult mesenchymal stem cells (MSCs) are considered as valuable mediators for tissue regeneration and cellular therapy. This study was performed to develop…”
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Therapy-induced tumour secretomes promote resistance and tumour progression by Obenauf, Anna C., Zou, Yilong, Ji, Andrew L., Vanharanta, Sakari, Shu, Weiping, Shi, Hubing, Kong, Xiangju, Bosenberg, Marcus C., Wiesner, Thomas, Rosen, Neal, Lo, Roger S., Massagué, Joan

“…Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that…”
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Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability by Mlecnik, Bernhard, Bindea, Gabriela, Angell, Helen K., Maby, Pauline, Angelova, Mihaela, Tougeron, David, Church, Sarah E., Lafontaine, Lucie, Fischer, Maria, Fredriksen, Tessa, Sasso, Maristella, Bilocq, Amélie M., Kirilovsky, Amos, Obenauf, Anna C., Hamieh, Mohamad, Berger, Anne, Bruneval, Patrick, Tuech, Jean-Jacques, Sabourin, Jean-Christophe, Le Pessot, Florence, Mauillon, Jacques, Rafii, Arash, Laurent-Puig, Pierre, Speicher, Michael R., Trajanoski, Zlatko, Michel, Pierre, Sesboüe, Richard, Frebourg, Thierry, Pagès, Franck, Valge-Archer, Viia, Latouche, Jean-Baptiste, Galon, Jérôme

“…Microsatellite instability in colorectal cancer predicts favorable outcomes. However, the mechanistic relationship between microsatellite instability,…”
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Mutations in GNA11 in Uveal Melanoma by Van Raamsdonk, Catherine D, Griewank, Klaus G, Crosby, Michelle B, Garrido, Maria C, Vemula, Swapna, Wiesner, Thomas, Obenauf, Anna C, Wackernagel, Werner, Green, Gary, Bouvier, Nancy, Sozen, M. Mert, Baimukanova, Gail, Roy, Ritu, Heguy, Adriana, Dolgalev, Igor, Khanin, Raya, Busam, Klaus, Speicher, Michael R, O'Brien, Joan, Bastian, Boris C

“…A specific amino acid in the Gα 11 subunit of heterotrimeric G proteins was mutated in 32% of primary uveal melanomas and in 57% of uveal melanoma metastases…”
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses by Bayerl, Felix, Meiser, Philippa, Donakonda, Sainitin, Hirschberger, Anna, Lacher, Sebastian B., Pedde, Anna-Marie, Hermann, Chris D., Elewaut, Anais, Knolle, Moritz, Ramsauer, Lukas, Rudolph, Thomas J., Grassmann, Simon, Öllinger, Rupert, Kirchhammer, Nicole, Trefny, Marcel, Anton, Martina, Wohlleber, Dirk, Höchst, Bastian, Zaremba, Anne, Krüger, Achim, Rad, Roland, Obenauf, Anna C., Schadendorf, Dirk, Zippelius, Alfred, Buchholz, Veit R., Schraml, Barbara U., Böttcher, Jan P.

“…Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to sustain…”
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Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients by Mlecnik, Bernhard, Bindea, Gabriela, Angell, Helen K, Sasso, Maria Stella, Obenauf, Anna C, Fredriksen, Tessa, Lafontaine, Lucie, Bilocq, Amelie M, Kirilovsky, Amos, Tosolini, Marie, Waldner, Maximilian, Berger, Anne, Fridman, Wolf Herman, Rafii, Arash, Valge-Archer, Viia, Pagès, Franck, Speicher, Michael R, Galon, Jérôme

“…The tumor microenvironment is host to a complex network of cytokines that contribute to shaping the intratumoral immune reaction. Chromosomal gains and losses,…”
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Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations by Jacob, Leni S, Vanharanta, Sakari, Obenauf, Anna C, Pirun, Mono, Viale, Agnes, Socci, Nicholas D, Massagué, Joan

“…Several experimental models faithfully recapitulate many important facets of human metastatic disease. Here, we have performed whole-exome sequencing in five…”
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