Search Results - "Obata, Toshio"

Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP +)-induced hydroxyl radical generation in the rat striatum by Obata, Toshio

“…The present study was examined that the desferrioxamine, a strong iron (III) chelator, enhanced 1 methyl-4-phenylpyridinium ion (MPP +)-induced hydroxyl…”
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Evidence for existence of thyroid hormone inducible semicarbazide-sensitive amine oxidase (SSAO) in rat heart cytosol by Obata, Toshio, Nakashima, Michiko

“…Abstract Background Despite semicarbazide-sensitive amine oxidase (SSAO; EC; 1.4.3.6.) widespread tissue distribution, the physiological role of SSAO is quite…”
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Blocking cardiac ATP-sensitive K + channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium by Obata, Toshio

“…The current study examined whether opening of the ATP-sensitive K + (K ATP) channel can induce hydroxyl free radical ( OH) generation, as detected by increases…”
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Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping by Obata, Toshio

“…Reactive oxygen species have been implicated in dopaminergic toxicity caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and iron. Although MPTP…”
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Glutaminergic tonic action potentiate MPP+-induced hydroxyl radical production in rat striatum by Obata, Toshio

“…•The effect of glycine on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (OH) formation of rat striatum were investigated.•MPP+-induced OH…”
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Formation of hydroxy radicals by environmental estrogen-like chemicals in rat striatum by Obata, Toshio, Kubota, Shunichiro

“…We investigated effects of environmental estrogen-like chemicals, para-nonylphenol and bisphenol A, on hydroxy radical formation in the striatum of adult rats,…”
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Imidaprilat suppresses nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP +)-induced hydroxyl radical generation in rat striatum by Obata, Toshio

“…The present study examined the antioxidant effects of angiotensin-converting enzyme inhibitor (ACE), imidaprilat, on para-nonylphenol and…”
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The effect of tamoxifen on opening ATP-sensitive K+ channels enhances hydroxyl radical generation in rat striatum by Obata, Toshio

“…•The present study was undertaken to clarify whether the OH generation is due to opening of KATP channels in rat striatum.•Tamoxifen significantly decreased…”
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Voltammetric Behavior of Mediator-Modified Electrode by Electrochemical Polymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain by Kashiwagi, Yoshitomo, Ono, Tetsuya, Tsunoda, Makiko, Takahashi, Shigehiro, Obata, Toshio, Sone, Takanori

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Block of Cardiac ATP-Sensitive K+ Channels Reduces Hydroxyl Radicals in the Rat Myocardium by Obata, Toshio, Yamanaka, Yasumitsu

“…The present study examined whether opening of an ATP-sensitive K+ (KATP) channel can induce hydroxyl free radical (•OH) generation in the rat myocardium…”
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Oxidative stress inactivates ecto-5'-nucleotidase by inhibiting protein kinase C in rat hearts in vivo by Obata, Toshio, Nakashima, Michiko

“…Examined in the present study, allopurinol are xanthine oxidase inhibitors for use in rat hearts in vivo dialysis technology and ventricular myocardial…”
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Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium by Obata, Toshio, Nakashima, Michiko

“…The present study examined whether ischemia-reperfusion-induced hydroxyl radical (·OH) generation was attenuated by myo-inositol hexaphosphoric acid (phytic…”
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Modulation of the stress response by coffee: an in vivo microdialysis study of hippocampal serotonin and dopamine levels in rat by Yamato, Takako, Yamasaki, Satomi, Misumi, Yukiko, Kino, Mayuko, Obata, Toshio, Aomine, Masahiro

“…We studied whether coffee and its components (caffeine and chlorogenic acid) have stress-relaxing effects. In vivo brain microdialysis was used to characterize…”
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Opening of ATP-sensitive K+ (KATP ) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum by Obata, Toshio, Nakashima, Michiko

“…Abstract The present study examined whether opening of adenosine triphosphate (ATP) sensitive K+ (KATP ) channels can enhance 1-methyl-4-phenylpyridinium (MPP+…”
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Protective effect of imidaprilat, a new angiotensin-converting enzyme inhibitor against 1-methyl-4-phenylpyridinium ion-induced ⋅OH generation in rat striatum by Obata, Toshio

“…We examined the antioxidant effects of angiotensin-converting enzyme inhibitor on 1-methyl-4-phenylpyridinium ion (MPP +)-induced hydroxyl radical (⋅OH)…”
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Fluvastatin, an HMG-CoA reductase inhibitor, facilitate adenosine production in the rat hearts via activation of ecto-5′-nucleotidase by Obata, Toshio, Nakashima, Michiko

“…The present study was examined whether fluvastatin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can increase the production of…”
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Use of Microdialysis for In-vivo Monitoring of Hydroxyl Free-radical Generation in the Rat by OBATA, TOSHIO

“…Free‐radicals are reported to cause the tissue‐damage associated with some toxins and diseases, yet there is no suitable method for routine in‐vivo monitoring…”
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Protective effect of histidine on para-nonylphenol-enhanced hydroxyl free radical generation induced by 1-methyl-4-phenylpyridinium ion (MPP +) in rat striatum by Obata, Toshio, Kubota, Shunichiro, Yamanaka, Yasumitsu

“…The present study examined the antioxidant effect of histidine, a singlet oxygen ( 1O 2) scavenger, on para-nonylphenol (an environmental estrogen-like…”
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Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: effects of MPP by Chiueh, C C, Krishna, G, Tulsi, P, Obata, T, Lang, K, Huang, S J, Murphy, D L

“…Ringer's solution containing salicylic acid (5 nmol/microliters/min) was infused directly through an intracranial microdialysis probe to detect the generation…”
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Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5'-nucleotidase in rat hearts by Obata, Toshio, Yonemochi, Hidetoshi, Arita, Makoto

“…We examined whether the increase of the extracellular potassium ion concentration, [K(+)](o), can increase the production of interstitial adenosine in the…”
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