Search Results - "Obata, Koichi"

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury by Miyoshi, Kan, Obata, Koichi, Kondo, Takashi, Okamura, Haruki, Noguchi, Koichi

“…Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here we show that both the IL-18 and IL-18 receptor (IL-18R), which are…”
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BDNF in sensory neurons and chronic pain by Obata, Koichi, Noguchi, Koichi

“…Neurotrophic factors, which support neuronal survival and growth during development of the nervous system, have been shown to play significant roles in the…”
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MAPK activation in nociceptive neurons and pain hypersensitivity by Obata, Koichi, Noguchi, Koichi

“…Extracellular signal-regulated protein kinase (ERK) is a mitogen-activated protein kinase (MAPK) that mediates intracellular signal transduction in response to…”
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Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain by Wang, Shenglan, Dai, Yi, Fukuoka, Tetsuo, Yamanaka, Hiroki, Kobayashi, Kimiko, Obata, Koichi, Cui, Xiuyu, Tominaga, Makoto, Noguchi, Koichi

“…Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors. TRPA1…”
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Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain by Dai, Yi, Wang, Shenglan, Tominaga, Makoto, Yamamoto, Satoshi, Fukuoka, Tetsuo, Higashi, Tomohiro, Kobayashi, Kimiko, Obata, Koichi, Yamanaka, Hiroki, Noguchi, Koichi

“…Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation…”
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Activation of Src-Family Kinases in Spinal Microglia Contributes to Mechanical Hypersensitivity after Nerve Injury by Katsura, Hirokazu, Obata, Koichi, Mizushima, Toshiyuki, Sakurai, Jun, Kobayashi, Kimiko, Yamanaka, Hiroki, Dai, Yi, Fukuoka, Tetsuo, Sakagami, Masafumi, Noguchi, Koichi

“…Hypersensitivity to mechanical stimulation is a well documented symptom of neuropathic pain, for which there is currently no effective therapy. Src-family…”
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Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord by Kobayashi, Kimiko, Fukuoka, Tetsuo, Yamanaka, Hiroki, Dai, Yi, Obata, Koichi, Tokunaga, Atsushi, Noguchi, Koichi

“…We examined the precise distribution of mRNAs for six cloned rat P2Y receptor subtypes, P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, and P2Y14, in the dorsal root ganglion…”
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Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation by Obata, Koichi, Yamanaka, Hiroki, Kobayashi, Kimiko, Dai, Yi, Mizushima, Toshiyuki, Katsura, Hirokazu, Fukuoka, Tetsuo, Tokunaga, Atsushi, Noguchi, Koichi

“…To investigate whether activation of mitogen-activated protein kinase (MAPK) in damaged and/or undamaged primary afferents participates in neuropathic pain…”
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Differential Activation of Extracellular Signal-Regulated Protein Kinase in Primary Afferent Neurons Regulates Brain-Derived Neurotrophic Factor Expression after Peripheral Inflammation and Nerve Injury by Obata, Koichi, Yamanaka, Hiroki, Dai, Yi, Tachibana, Toshiya, Fukuoka, Tetsuo, Tokunaga, Atsushi, Yoshikawa, Hideki, Noguchi, Koichi

“…To investigate the intracellular signal transduction pathways involved in regulating the gene expression of brain-derived neurotrophic factor (BDNF) in primary…”
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Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury by Katsura, Hirokazu, Obata, Koichi, Miyoshi, Kan, Kondo, Takashi, Yamanaka, Hiroki, Kobayashi, Kimiko, Dai, Yi, Fukuoka, Tetsuo, Sakagami, Masafumi, Noguchi, Koichi

“…Mitogen‐activated protein kinase (MAPK) plays an important role in the induction and maintenance of neuropathic pain. Transforming growth factor‐activated…”
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Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats by Obata, Koichi, Yamanaka, Hiroki, Fukuoka, Tetsuo, Yi, Dai, Tokunaga, Atsushi, Hashimoto, Norio, Yoshikawa, Hideki, Noguchi, Koichi

“…Neuropathic pain models, such as the chronic constriction injury (CCI) model, are partial nerve injury models where there exist both intact and injured…”
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Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats by Obata, Koichi, Yamanaka, Hiroki, Dai, Yi, Mizushima, Toshiyuki, Fukuoka, Tetsuo, Tokunaga, Atsushi, Noguchi, Koichi

“…To investigate the intracellular signal transduction pathways involved in the pathophysiological mechanisms of neuropathic pain after partial nerve injury, we…”
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The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint by Seino, Daisuke, Tokunaga, Atsushi, Tachibana, Toshiya, Yoshiya, Shinichi, Dai, Yi, Obata, Koichi, Yamanaka, Hiroki, Kobayashi, Kimiko, Noguchi, Koichi

“…Pain during inflammatory joint diseases is enhanced by the generation of hypersensitivity in nociceptive neurons in the peripheral nervous system. To explore…”
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Roles of extracellular signal‐regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain by Obata, Koichi, Katsura, Hirokazu, Mizushima, Toshiyuki, Sakurai, Jun, Kobayashi, Kimiko, Yamanaka, Hiroki, Dai, Yi, Fukuoka, Tetsuo, Noguchi, Koichi

“…Neuropathic pain that occurs after peripheral nerve injury is poorly controlled by current therapies. Increasing evidence shows that mitogen‐activated protein…”
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Suppression of the p75 Neurotrophin Receptor in Uninjured Sensory Neurons Reduces Neuropathic Pain after Nerve Injury by Obata, Koichi, Katsura, Hirokazu, Sakurai, Jun, Kobayashi, Kimiko, Yamanaka, Hiroki, Dai, Yi, Fukuoka, Tetsuo, Noguchi, Koichi

“…The p75 neurotrophin receptor (p75NTR) has been implicated in diverse neuronal responses, including survival, cell death, myelination, and inhibition of…”
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Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat by Kobayashi, Kimiko, Fukuoka, Tetsuo, Yamanaka, Hiroki, Dai, Yi, Obata, Koichi, Tokunaga, Atsushi, Noguchi, Koichi

“…The ionotropic purine receptors, P2X receptors, are composed of an assembly of multiple P2X subunits. At present, seven subunits have been cloned and named…”
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Differential Activation of p38 and Extracellular Signal-Regulated Kinase in Spinal Cord in a Model of Bee Venom-Induced Inflammation and Hyperalgesia by Cui, Xiu-Yu, Dai, Yi, Wang, Sheng-Lan, Yamanaka, Hiroki, Kobayashi, Kimiko, Obata, Koichi, Chen, Jun, Noguchi, Koichi

“…Background: Honeybee's sting on human skin can induce ongoing pain, hyperalgesia and inflammation. Injection of bee venom (BV) into the intraplantar surface of…”
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Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury by Kozai, Toyoko, Yamanaka, Hiroki, Dai, Yi, Obata, Koichi, Kobayashi, Kimiko, Mashimo, Takashi, Noguchi, Koichi

“…Dorsal root injury is known to induce alteration of the extracellular environment in the spinal cord and synaptic reorganization with degradation of injured…”
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Activation of Extracellular Signal-Regulated Protein Kinase in Sensory Neurons After Noxious Gastric Distention and Its Involvement in Acute Visceral Pain in Rats by Sakurai, Jun, Obata, Koichi, Ozaki, Noriyuki, Tokunaga, Atsushi, Kobayashi, Kimiko, Yamanaka, Hiroki, Dai, Yi, Kondo, Takashi, Miyoshi, Kan, Sugiura, Yasuo, Matsumoto, Takayuki, Miwa, Hiroto, Noguchi, Koichi

“…Background & Aims: Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about…”
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Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia by Mizushima, Toshiyuki, Obata, Koichi, Yamanaka, Hiroki, Dai, Yi, Fukuoka, Tetsuo, Tokunaga, Atsushi, Mashimo, Takashi, Noguchi, Koichi

“…Alterations in the intracellular signal transduction pathway in primary afferents may contribute to pain hypersensitivity. We demonstrated that very rapid…”
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