Traditional herbal remedies that influence cell adhesion molecule activity

Many traditional medicines have demonstrated immune activity, however, research has largely neglected their effects on cell adhesion molecules (CAMs). This review reports on extracts from 37 medicinal plant species, similar to or replicating traditional preparations, that up- or downregulate either...

Full description

Saved in:

Bibliographic Details
Published in:	Phytotherapy research Vol. 25; no. 4; pp. 473 - 483
Main Authors:	Spelman, K, Aldag, R, Hamman, A, Kwasnik, E.M, Mahendra, M.A, Obasi, T.M, Morse, J, Williams, E.J
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-04-2011 Wiley
Subjects:	Artemisia Biological and medical sciences Boswellia serrata cell adhesion cell adhesion molecules Cell Adhesion Molecules - physiology Cinnamomum Ganoderma lucidum General pharmacology Ginkgo biloba Herbal Medicine Hypericum perforatum ICAM integrins Juglans regia Lycopus lucidus Mahonia aquifolium Medical sciences medicinal plants Medicine, Traditional Panax notoginseng Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytotherapy plant extracts Plants - classification Rheum Salvia miltiorrhiza selectins Species Specificity traditional medicine VCAM cell adhesion molecules ICAM Pharmacognosy Cell adhesion molecule selectins Medicinal plant VCAM integrins Integrin Treatment Folk medicine Plant origin Phytotherapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Many traditional medicines have demonstrated immune activity, however, research has largely neglected their effects on cell adhesion molecules (CAMs). This review reports on extracts from 37 medicinal plant species, similar to or replicating traditional preparations, that up- or downregulate either gene or protein activity of CAMs. The majority of the investigations were in vitro, primarily of the immunoglobulin superfamily of CAMs, specifically intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and secondarily on the integrin (CD11b or MAC-1) and selectin (E-selectin and P-selectin) families of CAMs. The following plant species have demonstrated modulation of multiple CAMs: Artemisia asiatica, Boswellia serrata, Canscora decussata, Cinnamomum povectum, Dehaasia incrassate, Ganoderma lucidum, Ginkgo biloba, Hypericum perforatum, Juglans regia, Lycopus lucidus, Panax notoginseng, Rheum undulatum, Salvia miltiorrhiza. Many other species have documented activity on one CAM. Currently there are limited in vivo/ex vivo investigations, including a clinical trial on Mahonia aquifolium. Although further evidence is needed, the data suggest that the reviewed botanical medicines may have the potential to provide therapeutic potential in disease processes involving CAMs. Additionally, the reported success of many of these plant extracts by traditional cultures and modern phytotherapists may involve the modulation of CAMs. Copyright © 2010 John Wiley & Sons, Ltd.
Bibliography:	http://dx.doi.org/10.1002/ptr.3350 ArticleID:PTR3350 ark:/67375/WNG-QR1CFCPM-Z istex:647FA6FBBACEB510E3B71DFF2E91D3FC24AD01C8 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.3350