Search Results - "Obase, Hiroyuki"

Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1, 2, 3-Benzotriazine Derivatives by NOMOTO, Yuji, OBASE, Hiroyuki, TAKAI, Haruki, TERANISHI, Masayuki, NAKAMURA, Joji, KUBO, Kazuhiro

“…A series of phthalazine and 1, 2, 3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in…”
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Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives by Ohshima, Etsuo, Otaki, Shizuo, Sato, Hideyuki, Kumazawa, Toshiaki, Obase, Hiroyuki, Ishii, Akio, Ishii, Hidee, Ohmori, Kenji, Hirayama, Noriaki

“…A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives was synthesized and demonstrated to be orally active antiallergic…”
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(E)-4-{2-[[3-(Indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy}butyric Acid Derivatives: A New Class of Steroid 5.alpha.-Reductase Inhibitors in the Rat Prostate. 1 by Kumazawa, Toshiaki, Takami, Hitoshi, Kishibayashi, Nobuyuki, Ishii, Akio, Nagahara, Yoshitomo, Hirayama, Noriaki, Obase, Hiroyuki

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Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives by NOMOTO, Yuji, OBASE, Hiroyuki, TAKAI, Haruki, HIRATA, Tadashi, TERANISHI, Masayuki, NAKAMURA, Joji, KUBO, Kazuhiro

“…A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in…”
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Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines by Kumazawa, Toshiaki, Harakawa, Hiroyuki, Obase, Hiroyuki, Oiji, Yoshimasa, Tanaka, Hiroshi, Shuto, Katsuichi, Ishii, Akio, Oka, Tetsuo, Nakamizo, Nobuhiro

“…A series of substituted 5,11-dihydro[1]benzoxepino[3,4-b]pyridines was synthesized and evaluated for antiulcer activity in water immersion/restrained stress…”
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Synthesis of a Dibenz(b,e)oxepin-Bovine Serum Albumin Conjugate for Radioimmunoassay of KW-4679((Z)-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic Acid Hydrochloride) by OHSHIMA, Etsuo, SATO, Hideyuki, OBASE, Hiroyuki, UCHIMURA, Tatsuo, KUWABARA, Takashi, KOBAYASHI, Satoshi

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Synthesis of 1′-Substituted 2-Amino-spiro [4H-3, 1-benzoxazine-4, 4′-piperidine] Derivatives by TAKAI, HARUKI, OBASE, HIROYUKI, TERANISHI, MASAYUKI

“…In the cyclization reaction of 4-hydroxy-4-[2-(N/-substituted carbamoyl) aminophenyl] piperidine derivatives (3) by treatment with acid, 2-amino-spiro [4H/-3,…”
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Cyclofunctionalization of Olefinic Urethanes and Ureas with Halogens. Synthesis of 1-Substituted Spiro [piperidine-4, 4'(3'H)-quinazolin]-2'(1'H)-one Derivatives by TAKAI, HARUKI, OBASE, HIROYUKI, TERANISHI, MASAYUKI

“…The cyclization reaction of 4-(2-carbamoylaminopheny1)-1, 2, 5, 6-tetrahydropyridine derivatives (9) and a4-(2-methoxycarbonylaminophenyl)-1, 2, 5,…”
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Studies on cardiotonic agents. III. Synthesis of 1-(1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl)-3-substituted 2-imidazolidinone and 2-imidazolidinethione derivatives by NOMOTO, Yuji, OBASE, Hiroyuki, TAKAI, Haruki, HIRATA, Tadashi, TERANISHI, Masayuki, NAKAMURA, Joji, OHNO, Tetsuji, KUBO, Kazuhiro

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A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6, 11-dihydrodibenz[b, e]oxepin Derivatives by OHSHIMA, Etsuo, KUMAZAWA, Toshiaki, TAKIZAWA, Hiroshi, HARAKAWA, Hiroyuki, SATO, Hideyuki, OBASE, Hiroyuki, OIJI, Yoshimasa, ISHII, Akio, ISHII, Hidee, OHMORI, Kenji

“…A new series of 11-substituted 6, 11-dihydrodibenz[b, e]oxepin derivatives was synthesized and evaluated for antiallergic activity. Convenient methods for the…”
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A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6, 11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives by KUMAZAWA, Toshiaki, OHSHIMA, Etsuo, HARAKAWA, Hiroyuki, SATO, Hideyuki, OBASE, Hiroyuki, OIJI, Yoshimasa, ISHII, Akio, ISHII, Hidee, OHMORI, Kenji

“…New methods for the preparation of multi-functionallized-6, 11-dihydrodibenz[b, e]oxepins were developed. The structural requirements of KW-4994 (1), a…”
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Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1 by Sasho, Setsuya, Obase, Hiroyuki, Ichikawa, Shunji, Kitazawa, Takio, Nonaka, Hiromi, Yoshizaki, Rika, Ishii, Akio, Shuto, Katsuichi

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Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1, 2, 3, 4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents by TAKAI, HARUKI, OBASE, HIROYUKI, NAKAMIZO, NOBUHIRO, TERANISHI, MASAYUKI, KUBO, KAZUHIRO, SHUTO, KATSUICHI, KASUYA, YUTAKA, SHIGENOBU, KOKI, HASHIKAMI, MAKIKO, KARASHIMA, NAOKO

“…A series of 1-and 3-(1-substituted 4-piperidinyl)-1, 2, 3, 4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the…”
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Effects of KW-3635, a Novel Dibenzoxepin Derivative of a Selective Thromboxane A2 Antagonist, on Human, Guinea Pig and Rat Platelets by Miki, Ichiro, Kishibayashi, Nobuyuki, Nonaka, Hiromi, Ohshima, Etsuo, Takami, Hitoshi, Obase, Hiroyuki, Ishii, Akio

“…We examined the binding of [3H]U-46619, a thromboxane A2 agonist, to human and guinea pig platelets and the binding of [3H]SQ 29, 548, a thromboxane A2…”
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New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones by OBASE, HIROYUKI, NAKAMIZO, NOBUHIRO, TAKAI, HARUKI, TERANISHI, MASAYUKI, KUBO, KAZUHIRO, SHUTO, KATSUICHI, KASUYA, YUTAKA, SHIGENOBU, KOKI

“…As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only…”
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New Antihypertensive Agents. III. Synthesis and Antihypertensive Activity of Some Arylalkyl Piperidines Carrying a Heterocycle at the 4-Position by OBASE, HIROYUKI, NAKAMIZO, NOBUHIRO, TAKAI, HARUKI, TERANISHI, MASAYUKI, KUBO, KAZUHIRO, SHUTO, KATSUICHI, KASUYA, YUTAKA, SHIGENOBU, KOKI, HASHIKAMI, MAKIKO

“…We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the…”
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New Antihypertensive Agents. I. Synthesis and Antihypertensive Activity of Some 4-Piperidylbenzimidazolinone Derivatives by OBASE, HIROYUKI, NAKAMIZO, NOBUHIRO, TAKAI, HARUKI, TERANISHI, MASAYUKI, KUBO, KAZUHIRO, SHUTO, KATSUICHI, KASUYA, YUTAKA, KATO, HITOSHI, SHIGENOBU, KOKI, KURIHARA, JUNICHI

“…A series of 4-piperidylbenzimidazolinones, of formula I, has been synthesized. Selective syntheses of erythro and threo isomers of α-alkyl phenylethanolamines…”
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Synthesis and Adrenergic β-Blocking Activity of Some Propanolamine Derivatives by OBASE, HIROYUKI, TATSUNO, HIDEKO, GOTO, KATSUTOSHI, SHIGENOBU, KOKI, KASUYA, YUTAKA, YAMADA, YOSHIYUKI, FUJII, KYOICHI, YADA, SEIICHI

“…Some propanolamine derivatives were synthesized and their β-adrenergic blocking activities were determined. Among the compounds tested, all compounds with…”
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Effects of KW-3635, a Novel Dibenzoxepin Derivative of a Selective Thromboxane A2 Antagonist, on Human, Guinea Pig and Rat Platelets by Miki, Ichiro, Kishibayashi, Nobuyuki, Nonaka, Hiromi, Ohshima, Etsuo, Takami, Hitoshi, Obase, Hiroyuki, Ishii, Akio

“…We examined the binding of [3H]U-46619, a thromboxane A2 agonist, to human and guinea pig platelets and the binding of [3H]SQ 29,548, a thromboxane A2…”
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Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. 1. Synthesis and Hypocholesterolemic Activity of Dibenz[b,e]oxepin-11-carboxanilides by Kumazawa, Toshiaki, Yanase, Masashi, Harakawa, Hiroyuki, Obase, Hiroyuki, Shirakura, Shiro, Ohishi, Eiko, Oda, Shoji, Kubo, Kazuhiro, Yamada, Koji

“…A series of N-phenyl-6,11-dihydrodibenz[b,e]oxepin-11-carboxamides and related derivatives were prepared on the basis of structures of the reported inhibitors…”
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