Military risk factors for Alzheimer's disease

Abstract Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Vete...

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Bibliographic Details
Published in:	Alzheimer's & dementia Vol. 9; no. 4; pp. 445 - 451
Main Authors:	Weiner, Michael W, Friedl, Karl E, Pacifico, Anthony, Chapman, Julie C, Jaffee, Michael S, Little, Deborah M, Manley, Geoffrey T, McKee, Ann, Petersen, Ronald C, Pitman, Roger K, Yaffe, Kristine, Zetterberg, Henrik, Obana, Robert, Bain, Lisa J, Carrillo, Maria C
Format:	Journal Article Conference Proceeding
Language:	English
Published:	United States Elsevier Inc 01-07-2013
Subjects:	Afghan Campaign 2001 afghanistan Aging Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer's disease Alzheimer's Disease Neuroimaging Initiative Apolipoprotein E e4 Beta-amyloid Biomarkers blast Blast Injuries - epidemiology Blast Injuries - psychology Blast injury Brain Damage, Chronic - epidemiology Brain Damage, Chronic - etiology Brain Injuries - diagnosis Brain Injuries - epidemiology Brain Injuries - psychology care Chronic traumatic encephalopathy cognitive reserve Databases, Factual - statistics & numerical data Early Diagnosis encephalopathy Government Programs - methods Government Programs - organization & administration head-injury health Health initiatives Humans Iraq Iraq War, 2003-2011 Medical research Military medicine Military Medicine - organization & administration Military Personnel - psychology Military Personnel - statistics & numerical data Multicenter Studies as Topic - statistics & numerical data National Institute of Neurological Disorders and Stroke (U.S.) Neuroimaging Neurologi Neurology postconcussive Posttraumatic stress disorder Posttraumatie stress Risk Factors Stress Disorders, Post-Traumatic - epidemiology Stress Disorders, Post-Traumatic - psychology symptoms Tau Traumatic brain injury United States United States Department of Defense - organization & administration United States Department of Veterans Affairs - organization & administration Veterans Veterans Health - statistics & numerical data Vietnam Afghanistan Military medicine Traumatic brain injury Veterans Beta-amyloid Apolipoprotein E e4 Tau Blast injury Posttraumatic stress disorder Risk factors Alzheimer's Disease Neuroimaging Initiative Vietnam Chronic traumatic encephalopathy Biomarkers Alzheimer's disease
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Summary:	Abstract Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.
Bibliography:	ObjectType-Conference-1 SourceType-Conference Papers & Proceedings-1 content type line 25 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1552-5260 1552-5279
DOI:	10.1016/j.jalz.2013.03.005