Search Results - "Oatman, Nicole"

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival by Muraleedharan, Ranjithmenon, Gawali, Mruniya V., Tiwari, Durgesh, Sukumaran, Abitha, Oatman, Nicole, Anderson, Jane, Nardini, Diana, Bhuiyan, Mohammad Alfrad Nobel, Tkáč, Ivan, Ward, Amber Lynne, Kundu, Mondira, Waclaw, Ronald, Chow, Lionel M., Gross, Christina, Rao, Raghavendra, Schirmeier, Stefanie, Dasgupta, Biplab

“…Lactate is used as an energy source by producer cells or shuttled to neighboring cells and tissues. Both glucose and lactate fulfill the bioenergetic demand of…”
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HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells by De Vos, Tamara, Oatman, Nicole, Boehme, Lena, Putteman, Tom, Velghe, Imke, Van Droogenbroeck, Yana, De Munter, Stijn, Cesnekova, Michaela, Van Nieuwerburgh, Filip, Vandekerckhove, Bart, Philippe, Jan, Taghon, Tom

“…Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the…”
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Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer by Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V, Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A, Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T, D'Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab

“…The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a…”
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The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas by Anderson, Jane L, Muraleedharan, Ranjithmenon, Oatman, Nicole, Klotter, Amanda, Sengupta, Satarupa, Waclaw, Ronald R, Wu, Jianqiang, Drissi, Rachid, Miles, Lili, Raabe, Eric H, Weirauch, Matthew L, Fouladi, Maryam, Chow, Lionel M, Hoffman, Lindsey, DeWire, Mariko, Dasgupta, Biplab

“…Diffuse intrinsic pontine glioma (DIPG) is a high-grade brainstem glioma of children with dismal prognosis. There is no single unifying model about the cell of…”
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EXTH-50. THE COMPLEXITIES OF FATTY ACID DESATURATION IN GLIOBLASTOMA by Oatman, Nicole, Dasgupta, Biplab

“…Abstract Fatty acid desaturation is an enzymatic reaction in which a double bond is introduced into an acyl chain. Monounsaturated fatty acids (MUFA) are…”
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DDRE-15. THE EVOLUTIONARY ENIGMA OF FATTY ACID DESATURATION IN GLIOBLASTOMA by Oatman, Nicole, Dasgupta, Biplab

“…Abstract Fatty acid desaturation is an enzymatic reaction in which a double bond is introduced into an acyl chain. Of the four functionally distinct desaturase…”
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TAMI-55. THE EVOLUTIONARY ENIGMA OF FATTY ACID DESATURATION IN GLIOBLASTOMA by Oatman, Nicole, Reisz, Julie, D’Alessandro, Angelo, Dasgupta, Biplab

“…Abstract Fatty acid desaturation is an enzymatic reaction in which a double bond is introduced into an acyl chain. Of the four functionally distinct desaturase…”
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HES6knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells by De Vos, Tamara, Oatman, Nicole, Boehme, Lena, Putteman, Tom, Velghe, Imke, Van Droogenbroeck, Yana, De Munter, Stijn, Cesnekova, Michaela, Van Nieuwerburgh, Filip, Vandekerckhove, Bart, Philippe, Jan, Taghon, Tom

“…Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the…”
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An unexpected role for IRF8 during human T cell development by Taghon, Tom N, Liang, Kai Ling, Lavaert, Marieke, Roels, Juliette, Strubbe, Steven, Lambrechts, Nina, De Vos, Tamara, Boehme, Lena, Van Hulle, Jolien, Oatman, Nicole, Putteman, Tom, Velghe, Imke

“…Abstract Lineage tracing studies or other genetic approaches have allowed investigators to obtain detailed insights into the molecular mechanisms that control…”
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A multimodal drug-diet-immunotherapy combination restrains melanoma progression and metastasis by Oatman, Nicole, Gawali, Mruniya V, Congrove, Sunny, Caceres, Roman, Sukumaran, Abitha, Gupta, Nishtha, Murugesan, Narmadha, Arora, Priyanka, Subramanian, Sri Vidhya, Choi, Kwangmin, Abdel-Malek, Zalfa, Reisz, Julie A, Stephenson, Daniel, Amaravadi, Ravi, Desai, Pankaj, D'Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab

“…The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to…”
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Abstract 1399: Passenger deletion vulnerability in glioblastoma by Oatman, Nicole, Komurov, Kakajan, Arora, Priyanka, Desai, Pankaj, Dasgupta, Nupur, Choi, Kwangmin, Dasgupta, Biplab

“…Abstract Glioblastoma multiforme (GBM) is the most common, aggressive and lethal primary brain tumor in humans. Despite aggressive therapy the median survival…”
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Mechanisms Regulating Cancer Cell Sensitivity and Acquired Resistance to Stearoyl-CoA Desaturase Inhibition by Oatman, Nicole

“…Glioblastoma (GBM) is the most common malignant glioma in adults. It is highly infiltrative and incurable. Several key enzymes of the lipogenic pathway are…”
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CBMT-05. GENETIC AND EPIGENETIC MECHANISMS REGULATING SCD INHIBITOR SENSITIVITY IN GLIOBLASTOMA by Oatman, Nicole, Dasgupta, Nupur, Dasgupta, Biplab, Dasgupta, Biplab, Choi, Kwangmin, Gawali, Mruniya, Gupta, Nishtha, Parameswaran, Sreeja, Lawler, Sean, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Desai, Pankaj, Weirauch, Matthew, Komurov, Kakajan

“…Abstract A status-quo in targeted cancer therapy is that out of the thousands of somatic alterations found in a cancer cell, alterations only in driver genes…”
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TMOD-40. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS by White, Angela, Kumar, Shiva, Smith, Amanda, Ramkissoon, Annmarie, Oatman, Nicole, Dasgupta, Biplab, Breese, Erin, Stevenson, Charles, Fuller, Christine, Fouladi, Maryam, DeWire, Mariko, Drissi, Rachid, Chow, Lionel M L

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TMOD-10. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS by White, Angela R., Kumar, Shiva Senthil, Smith, Amanda R., Ramkissoon, Annmarie, Oatman, Nicole, Dasgupta, Biplab, Breese, Erin H., Stevenson, Charles, Fuller, Christine, Fouladi, Maryam, DeWire, Mariko D., Drissi, Rachid, Chow, Lionel M.L.

“…BACKGROUND: Pediatric glioblastomas (pGBM) are characterized by overlapping and unique molecular driver mutations compared to their adult counterparts. Primary…”
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Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer by Facista, Alexander, Nguyen, Huy, Lewis, Cristy, Prasad, Anil R, Ramsey, Lois, Zaitlin, Beryl, Nfonsam, Valentine, Krouse, Robert S, Bernstein, Harris, Payne, Claire M, Stern, Stephen, Oatman, Nicole, Banerjee, Bhaskar, Bernstein, Carol

“…Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or…”
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