Search Results - "Oare, David"

Minimization of a Polypeptide Hormone by Li, Bing, Jeff Y. K. Tom, Oare, David, Yen, Randy, Fairbrother, Wayne J., Wells, James A., Cunningham, Brian C.

“…A stepwise approach for reducing the size of a polypeptide hormone, atrial natriuretic peptide (ANP), from 28 residues to 15 while retaining high biopotency is…”
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Acyclic stereoselection. 47. Stereochemistry of the Michael addition of ester and ketone enolates to .alpha.,.beta.-unsaturated ketones by Oare, David A, Heathcock, Clayton H

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Acyclic stereoselection. 46. Stereochemistry of the Michael addition of N,N-disubstituted amide and thioamide enolates to .alpha.,.beta.-unsaturated ketones by Oare, David A, Henderson, Mark A, Sanner, Mark A, Heathcock, Clayton H

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Acyclic stereoselection. 31. Stereoselection in the Michael addition reaction. 3. Relationship between ester enolate geometry and adduct stereochemistry in the kinetic Michael reaction of lithium enolates with enones by Heathcock, Clayton H, Oare, David A

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Substituted imidazopyridines as potent inhibitors of HCV replication by Vliegen, Inge, Paeshuyse, Jan, De Burghgraeve, Tine, Lehman, Laura S, Paulson, Matthew, Shih, I-Hung, Mabery, Eric, Boddeker, Nina, De Clercq, Erik, Reiser, Hans, Oare, David, Lee, William A, Zhong, Weidong, Bondy, Steven, Pürstinger, Gerhard, Neyts, Johan

“…Background/Aims Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV…”
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Acyclic stereoselection. 30. Stereoselection in the Michael addition reaction. 2. Stereochemistry of the kinetic Michael reaction of amide enolates with enones by Heathcock, Clayton H, Henderson, Mark A, Oare, David A, Sanner, Mark A

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Substituted Imidazopyridines as Potent Inhibitors of Hepatitis C Virus Replication that Target the Viral Polymerase by Vliegen, Inge, Paeshuyse, Jan, Lehman, Laura S., Zhong, Weidong, Roofthooft, Sofie, Dutartre, Hélène, Selisko, Barbara, Canard, Bruno, Boddeker, Nina, Bondy, Steven, Oare, David, De Clercq, Erik, Lee, William A., Pürstinger, Gerhard, Neyts, Johan

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Novel analog of atrial natriuretic peptide selective for receptor-A produces increased diuresis and natriuresis in rats by Jin, H, Li, B, Cunningham, B, Tom, J, Yang, R, Sehl, P, Thomas, G R, Ko, A, Oare, D, Lowe, D G

“…Atrial natriuretic peptide (ANP) binds to natriuretic peptide receptor-A (NPR-A), a membrane guanylyl cyclase, and to natriuretic peptide receptor-C (NPR-C),…”
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Benzodiazepine peptidomimetic inhibitors of farnesyltransferase by Marsters, Jr, J C, McDowell, R S, Reynolds, M E, Oare, D A, Somers, T C, Stanley, M S, Rawson, T E, Struble, M E, Burdick, D J, Chan, K S

“…A structural survey of protein Zn2+ binding geometries was instigated based upon the functional requirement of Ras farnesyltransferase for Zn2+. The…”
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Receptor-specific ligands distinguish natriuretic peptide receptors-A and -C in primate tissues by Sehl, P, Tom, J Y, Oare, D, Lowe, D G

“…Systemic clearance of atrial natriuretic peptide (ANP) is in part due to neutral endopeptidase (NEP) proteolysis and natriuretic peptide receptor-C (NPR-C)…”
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