Search Results - "Oakley, Robert H."

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease by Oakley, Robert H., PhD, Cidlowski, John A., PhD

“…Glucocorticoids are primary stress hormones necessary for life that regulate numerous physiologic processes in an effort to maintain homeostasis. Synthetic…”
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Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids by Oakley, Robert H., Cidlowski, John A.

“…Glucocorticoids regulate numerous physiological processes and are mainstays in the treatment of inflammation, autoimmune disease, and cancer. The traditional…”
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Dual Role for Glucocorticoids in Cardiomyocyte Hypertrophy and Apoptosis by Ren, Rongqin, Oakley, Robert H, Cruz-Topete, Diana, Cidlowski, John A

“…Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids…”
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Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice by Oakley, Robert H, Cruz-Topete, Diana, He, Bo, Foley, Julie F, Myers, Page H, Xu, Xiaojiang, Gomez-Sanchez, Celso E, Chambon, Pierre, Willis, Monte S, Cidlowski, John A

“…Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates in patients with cardiometabolic disease. Glucocorticoids are…”
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Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer by Perez Kerkvliet, Carlos, Dwyer, Amy R, Diep, Caroline H, Oakley, Robert H, Liddle, Christopher, Cidlowski, John A, Lange, Carol A

“…Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR…”
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Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization by Whirledge, Shannon D., Oakley, Robert H., Myers, Page H., Lydon, John P., DeMayo, Francesco, Cidlowski, John A.

“…In addition to thewell-characterized role of the sex steroid receptors in fertility and reproduction, organs of the female reproductive tract are also…”
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Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression by Hauger, Richard L., Risbrough, Victoria, Oakley, Robert H., Olivares-Reyes, J. Alberto, Dautzenberg, Frank M.

“…Markers of hyperactive central corticotropin releasing factor (CRF) systems and CRF‐related single nucleotide polymorphisms (SNPs) have been identified in…”
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Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease by Oakley, Robert H., Ren, Rongqin, Cruz-Topete, Diana, Bird, Gary S., Myers, Page H., Boyle, Michael C., Schneider, Michael D., Willis, Monte S., Cidlowski, John A.

“…Heart failure is a leading cause of death in humans, and stress is increasingly associated with adverse cardiac outcomes. Glucocorticoids are primary stress…”
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Glucocorticoid Signaling and the Aging Heart by Cruz-Topete, Diana, Oakley, Robert H., Cidlowski, John A.

“…A decline in normal physiological functions characterizes the aging process. While some of these changes are benign, the decrease in the function of the…”
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Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus by Oakley, Robert H., Riddick, Natallia V., Moy, Sheryl S., Cidlowski, John A.

“…Many stress-related neuropsychiatric disorders display pronounced sex differences in their frequency and clinical symptoms. Glucocorticoids are primary stress…”
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Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors by Oakley, Robert H, Revollo, Javier, Cidlowski, John A

“…G protein-coupled receptors (GPCRs) compose the largest family of cell surface receptors and are the most common target of therapeutic drugs. The nonvisual…”
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Overcoming apoptotic resistance afforded by Bcl-2 in lymphoid tumor cells: a critical role for dexamethasone by Bortner, Carl D., Oakley, Robert H., Cidlowski, John A.

“…Bcl-2 is an anti-apoptotic protein that promotes cell survival and resistance to cell death. Predictably, Bcl-2 as well as other anti-apoptotic Bcl-2 family…”
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Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy by Hauger, Richard L., Olivares-Reyes, J. Alberto, Dautzenberg, Frank M., Lohr, James B., Braun, Sandra, Oakley, Robert H.

“…The reasons for differences in vulnerability or resilience to the development of posttraumatic stress disorder (PTSD) are unclear. Here we review key genetic…”
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Glucocorticoid Inhibition of Estrogen Regulation of the Serotonin Receptor 2B in Cardiomyocytes Exacerbates Cell Death in Hypoxia/Reoxygenation Injury by Dhaibar, Hemangini A, Carroll, Natalie G, Amatya, Shripa, Kamberov, Lilly, Khanna, Pranshu, Orr, A Wayne, Bailey, Steven R, Oakley, Robert H, Cidlowski, John A, Cruz-Topete, Diana

“…Background Stress has emerged as an important risk factor for heart disease in women. Stress levels have been shown to correlate with delayed recovery and…”
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Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure by Cruz-Topete, Diana, Oakley, Robert H, Carroll, Natalie G, He, Bo, Myers, Page H, Xu, Xiaojiang, Watts, Megan N, Trosclair, Krystle, Glasscock, Edward, Dominic, Paari, Cidlowski, John A

“…Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually…”
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Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus by Oakley, Robert H., Whirledge, Shannon D., Petrillo, Maria G., Riddick, Natallia V., Xu, Xiaojiang, Moy, Sheryl S., Cidlowski, John A.

“…Chronic stress contributes to numerous human pathologies including cognition impairments and psychiatric disorders. Glucocorticoids are primary stress hormones…”
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Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration by Corrales, Wladimir A, Silva, Juan P, Parra, Claudio S, Olave, Felipe A, Aguayo, Felipe I, Román-Albasini, Luciano, Aliaga, Esteban, Venegas-Zamora, Leslye, Avalos, Ana M, Rojas, Paulina S, Maracaja-Coutinho, Vinicius, Oakley, Robert H, Cidlowski, John A, Fiedler, Jenny L

“…We explored sex-biased effects of the primary stress glucocorticoid hormone corticosterone on the miRNA expression profile in the rat hippocampus. Adult…”
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Intestinal epithelial glucocorticoid receptor promotes chronic inflammation-associated colorectal cancer by Tang, Shuang, Zhang, Zhan, Oakley, Robert H, Li, Wenling, He, Weijing, Xu, Xiaojiang, Ji, Ming, Xu, Qing, Chen, Liang, Wellman, Alicia S, Li, Qingguo, Li, Leping, Li, Jian-Liang, Li, Xinxiang, Cidlowski, John A, Li, Xiaoling

“…Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory bowel disease (IBD). However, the impact of GC signaling on…”
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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice by Tejos-Bravo, Macarena, Oakley, Robert H., Whirledge, Shannon D., Corrales, Wladimir A., Silva, Juan P., García-Rojo, Gonzalo, Toledo, Jorge, Sanchez, Wendy, Román-Albasini, Luciano, Aliaga, Esteban, Aguayo, Felipe, Olave, Felipe, Maracaja-Coutinho, Vinicius, Cidlowski, John A., Fiedler, Jenny L.

“…Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This…”
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Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice by Oakley, Robert H, Campen, Matthew J, Paffett, Michael L, Chen, Xin, Wang, Zhongjing, Parry, Traci L, Hillhouse, Carolyn, Cidlowski, John A, Willis, Monte S

“…We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by…”
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