Search Results - "Oakley, R H"

Correction: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1 by Venturutti, L., Russo, R. I. Cordo, Rivas, M. A., Mercogliano, M. F., Izzo, F., Oakley, R. H., Pereyra, M. G., De Martino, M., Proietti, C. J., Yankilevich, P., Roa, J. C., Guzmán, P., Cortese, E., Allemand, D. H., Huang, T. H., Charreau, E. H., Cidlowski, J. A., Schillaci, R., Elizalde, P. V.

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MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1 by Venturutti, L, Cordo Russo, R I, Rivas, M A, Mercogliano, M F, Izzo, F, Oakley, R H, Pereyra, M G, De Martino, M, Proietti, C J, Yankilevich, P, Roa, J C, Guzmán, P, Cortese, E, Allemand, D H, Huang, T H, Charreau, E H, Cidlowski, J A, Schillaci, R, Elizalde, P V

“…ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2 expression was also found in…”
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Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor by ALLGOOD, V. E, OAKLEY, R. H, CIDLOWSKI, J. A

“…We have investigated the mechanism by which vitamin B6 acts to modulate steroid hormone-mediated gene expression. We show that the level of…”
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Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Caron, Marc G., Barak, Larry S.

“…Visual arrestin, βarrestin1, and βarrestin2 comprise a family of intracellular proteins that desensitize G protein-coupled receptors (GPCRs). In addition,…”
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Proinflammatory Cytokines Regulate Human Glucocorticoid Receptor Gene Expression and Lead to the Accumulation of the Dominant Negative β Isoform: A Mechanism for the Generation of Glucocorticoid Resistance by Webster, Jeffrey C., Oakley, Robert H., Jewell, Christine M., Cidlowski, John A.

“…Inflammatory responses in many cell types are coordinately regulated by the opposing actions of NF-κB and the glucocorticoid receptor (GR). The human…”
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Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Barak, Larry S., Caron, Marc G.

“…β-Arrestins bind agonist-activated G protein-coupled receptors (GPCRs) and mediate their desensitization and internalization. Although β-arrestins dissociate…”
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Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization by Oakley, Robert H., Laporte, Stéphane A., Holt, Jason A., Barak, Larry S., Caron, Marc G.

“…Resensitization of G protein-coupled receptors (GPCRs) following agonist-mediated desensitization is a necessary step for maintaining physiological…”
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The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action by Oakley, R H, Jewell, C M, Yudt, M R, Bofetiado, D M, Cidlowski, J A

“…Alternative splicing of the human glucocorticoid receptor gene generates a nonhormone binding splice variant (hGRbeta) that differs from the wild-type receptor…”
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The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function by Oakley, R H, Sar, M, Cidlowski, J A

“…Alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces two receptor isoforms, hGRalpha and hGRbeta, which differ at their…”
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Constitutive Arrestin-Mediated Desensitization of a Human Vasopressin Receptor Mutant Associated with Nephrogenic Diabetes Insipidus by Barak, Larry S., Oakley, Robert H., Laporte, Stéphane A., Caron, Marc G.

“…Agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCR) are mediated by the binding of arrestins to phosphorylated…”
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Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor by Oakley, R H, Webster, J C, Sar, M, Parker, Jr, C R, Cidlowski, J A

“…Alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces two highly homologous protein isoforms, termed hGR alpha and…”
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The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors by Oakley, Robert H, Hudson, Christine C, Cruickshank, Rachael D, Meyers, Diane M, Payne, Jr, Richard E, Rhem, Shay M, Loomis, Carson R

“…G protein-coupled receptors (GPCRs) have proven to be a rich source of therapeutic targets; therefore, finding compounds that regulate these receptors is a…”
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Homologous down regulation of the glucocorticoid receptor: the molecular machinery by Oakley, R H, Cidlowski, J A

“…The biological action of glucocorticoids is mediated by intracellular glucocorticoid receptors (GR) that, when bound by homologous ligand, function as…”
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Multiple benign mesenchymomata of the chest wall by OAKLEY, R. H, CARTY, H, CUDMORE, R. E

“…Chest wall mesenchymoma is a rare benign tumour arising from the ribs and occurring in infants, being usually present from birth. The few previously documented…”
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Review of spondylolisthesis and spondylolysis in paediatric practice by Oakley, R H, Carty, H

“…Presenting radiographs of 30 children with spondylolisthesis and spondylolysis were reviewed. A 67% incidence of spina bifida occulta was noted, a 13-fold…”
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Immunocytochemical analysis of the glucocorticoid receptor alpha isoform (GRα) using a GRα-specific antibody by Oakley, Robert H, Webster, Jeffrey C, Jewell, Christine M, Sar, Madhabananda, Cidlowski, John A

“…The alpha isoform of the glucocorticoid receptor (GRα) binds glucocorticoids and functions as a ligand-dependent transcription factor. Although GRα is…”
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Analysis of the chest radiograph in Legionnaires' disease by Evans, A F, Oakley, R H, Whitehouse, G H

“…The serial chest radiographic findings of 10 patients with Legionnaires' disease seen in Liverpool during 1980 are described. A unilateral lobar pneumonia was…”
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Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors by Oakley, Robert H, Revollo, Javier, Cidlowski, John A

“…G protein-coupled receptors (GPCRs) compose the largest family of cell surface receptors and are the most common target of therapeutic drugs. The nonvisual…”
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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation by Tohgo, Akira, Choy, Eric W, Gesty-Palmer, Diane, Pierce, Kristen L, Laporte, Stephane, Oakley, Robert H, Caron, Marc G, Lefkowitz, Robert J, Luttrell, Louis M

“…By binding to agonist-activated G protein-coupled receptors (GPCRs), beta-arrestins mediate homologous receptor desensitization and endocytosis via…”
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The glucocorticoid receptor: One gene, many proteins — New mechanisms for tissue specific anti-inflammatory actions of glucocorticoids in health and disease by Cidlowski, J.A, Lu, N.Z, Jewell, C.M, Beckley, A, Ren, R, Revollo, J, Lannan, E, Duma, D, Gross, K, Oakley, R.H

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