Search Results - "Oakley, C"

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response by Olson, Oakley C., Joyce, Johanna A.

“…Key Points In many cancer types cathepsin proteases are upregulated and display altered trafficking and localization. Increased cathepsin expression generally…”
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Obesity and the tumor microenvironment by Olson, Oakley C., Quail, Daniela F., Joyce, Johanna A.

“…Obesity-associated inflammation promotes tumor growth and metastatic spread Obesity is a growing global epidemic and rivals smoking as the leading preventable…”
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Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis by Yamashita, Masayuki, Dellorusso, Paul V., Olson, Oakley C., Passegué, Emmanuelle

“…Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages of blood and immune cells. The maintenance of blood homeostasis…”
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Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy by Hughes, Russell, Qian, Bin-Zhi, Rowan, Charlotte, Muthana, Munitta, Keklikoglou, Ioanna, Olson, Oakley C, Tazzyman, Simon, Danson, Sarah, Addison, Christina, Clemons, Mark, Gonzalez-Angulo, Ana Maria, Joyce, Johanna A, De Palma, Michele, Pollard, Jeffrey W, Lewis, Claire E

“…Tumor relapse after chemotherapy-induced regression is a major clinical problem, because it often involves inoperable metastatic disease. Tumor-associated…”
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Made to order: emergency myelopoiesis and demand-adapted innate immune cell production by Swann, James W., Olson, Oakley C., Passegué, Emmanuelle

“…Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haematopoietic cell lineages in healthy…”
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CSF-1R inhibition alters macrophage polarization and blocks glioma progression by Pyonteck, Stephanie M, Akkari, Leila, Schuhmacher, Alberto J, Bowman, Robert L, Sevenich, Lisa, Quail, Daniela F, Olson, Oakley C, Quick, Marsha L, Huse, Jason T, Teijeiro, Virginia, Setty, Manu, Leslie, Christina S, Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W, Sutton, James C, Holland, Eric C, Daniel, Dylan, Joyce, Johanna A

“…The authors provide preclinical testing of a CSFR-1 inhibitor in proneural glioma models. The compound targets macrophages in the tumor microenvironment rather…”
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Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF by Quail, Daniela F., Olson, Oakley C., Bhardwaj, Priya, Walsh, Logan A., Akkari, Leila, Quick, Marsha L., Chen, I-Chun, Wendel, Nils, Ben-Chetrit, Nir, Walker, Jeanne, Holt, Peter R., Dannenberg, Andrew J., Joyce, Johanna A.

“…Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between…”
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Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer by Shree, Tanaya, Olson, Oakley C, Elie, Benelita T, Kester, Jemila C, Garfall, Alfred L, Simpson, Kenishana, Bell-McGuinn, Katherine M, Zabor, Emily C, Brogi, Edi, Joyce, Johanna A

“…The microenvironment is known to critically modulate tumor progression, yet its role in regulating treatment response is poorly understood. Here we found…”
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Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents by Olson, Oakley C., Kim, Hyunjung, Quail, Daniela F., Foley, Emily A., Joyce, Johanna A.

“…Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of…”
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Polystyrene Upcycling into Fungal Natural Products and a Biocontrol Agent by Rabot, Chris, Chen, Yuhao, Lin, Shu-Yi, Miller, Ben, Chiang, Yi-Ming, Oakley, C. Elizabeth, Oakley, Berl R., Wang, Clay C. C., Williams, Travis J.

“…Polystyrene (PS) is one of the most used yet infrequently recycled plastics. Although manufactured on the scale of 300 million tons per year globally, current…”
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Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans by Elramli, Nadia, Karahoda, Betim, Sarikaya-Bayram, Özlem, Frawley, Dean, Ulas, Mevlüt, Oakley, C Elizabeth, Oakley, Berl R, Seiler, Stephan, Bayram, Özgür

“…Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes that control many cellular processes including development, cellular…”
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Commentary on ‘Physical Activity Monitoring in Patients with Peripheral Arterial Occlusive Disease: Validation of an Activity Monitor’ by Oakley, C

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Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing by Mitchell, Carl A., Verovskaya, Evgenia V., Calero-Nieto, Fernando J., Olson, Oakley C., Swann, James W., Wang, Xiaonan, Hérault, Aurélie, Dellorusso, Paul V., Zhang, Si Yi, Svendsen, Arthur Flohr, Pietras, Eric M., Bakker, Sietske T., Ho, Theodore T., Göttgens, Berthold, Passegué, Emmanuelle

“…Haematopoietic ageing is marked by a loss of regenerative capacity and skewed differentiation from haematopoietic stem cells (HSCs), leading to impaired blood…”
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Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration by Olson, Oakley C, Kang, Yoon-A, Passegué, Emmanuelle

“…The hematopoietic system is highly organized to maintain its functional integrity and to meet lifelong organismal demands. Hematopoietic stem cells (HSCs) must…”
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Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression by Bakst, Richard L, Xiong, Huizhong, Chen, Chun-Hao, Deborde, Sylvie, Lyubchik, Anna, Zhou, Yi, He, Shizhi, McNamara, William, Lee, Sei-Young, Olson, Oakley C, Leiner, Ingrid M, Marcadis, Andrea R, Keith, James W, Al-Ahmadie, Hikmat A, Katabi, Nora, Gil, Ziv, Vakiani, Efsevia, Joyce, Johanna A, Pamer, Eric, Wong, Richard J

“…Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells…”
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Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome by Cheah, Christine S, Yu, Frank H, Westenbroek, Ruth E, Kalume, Franck K, Oakley, John C, Potter, Gregory B, Rubenstein, John L, Catterall, William A

“…Heterozygous loss-of-function mutations in the brain sodium channel Na V1.1 cause Dravet syndrome (DS), a pharmacoresistant infantile-onset epilepsy syndrome…”
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Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin by Chiang, Yi-Ming, Ahuja, Manmeet, Oakley, C. Elizabeth, Entwistle, Ruth, Asokan, Anabanadam, Zutz, Christoph, Wang, Clay C. C., Oakley, Berl R.

“…To reduce the secondary metabolite background in Aspergillus nidulans and minimize the rediscovery of compounds and pathway intermediates, we created a…”
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A Versatile and Efficient Gene-Targeting System for Aspergillus nidulans by Nayak, Tania, Szewczyk, Edyta, Oakley, C. Elizabeth, Osmani, Aysha, Ukil, Leena, Murray, Sandra L, Hynes, Michael J, Osmani, Stephen A, Oakley, Berl R

“…Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as…”
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Fusion PCR and gene targeting in Aspergillus nidulans by Oakley, Berl R, Szewczyk, Edyta, Nayak, Tania, Oakley, C Elizabeth, Edgerton, Heather, Xiong, Yi, Taheri-Talesh, Naimeh, Osmani, Stephen A

“…We describe a rapid method for the production of fusion PCR products that can be used, generally without band purification, to transform Aspergillus nidulans…”
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An Efficient System for Heterologous Expression of Secondary Metabolite Genes in Aspergillus nidulans by Chiang, Yi-Ming, Oakley, C. Elizabeth, Ahuja, Manmeet, Entwistle, Ruth, Schultz, Aric, Chang, Shu-Lin, Sung, Calvin T, Wang, Clay C. C, Oakley, Berl R

“…Fungal secondary metabolites (SMs) are an important source of medically valuable compounds. Genome projects have revealed that fungi have many SM biosynthetic…”
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