Search Results - "Oakley, Berl R."
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The functions of myosin II and myosin V homologs in tip growth and septation in Aspergillus nidulans
Published in PloS one (16-02-2012)“…Because of the industrial and medical importance of members of the fungal genus Aspergillus, there is considerable interest in the functions of cytoskeletal…”
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Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans
Published in Journal of the American Chemical Society (14-03-2012)“…Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid…”
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3
Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex
Published in Nature communications (14-11-2023)“…Production of secondary metabolites is controlled by a complicated regulatory network in eukaryotic cells. Several layers of regulators are involved in this…”
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A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
Published in Journal of the American Chemical Society (04-03-2009)“…The genome sequencing of Aspergillus species including A. nidulans reveals that the products of many of the secondary metabolism pathways in these fungi have…”
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5
Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
Published in Current opinion in chemical biology (01-02-2011)“…Secondary metabolites from microorganisms have a broad spectrum of applications, particularly in therapeutics. The growing number of sequenced microbial…”
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Genome-Based Deletion Analysis Reveals the Prenyl Xanthone Biosynthesis Pathway in Aspergillus nidulans
Published in Journal of the American Chemical Society (23-03-2011)“…Xanthones are a class of molecules that bind to a number of drug targets and possess a myriad of biological properties. An understanding of xanthone…”
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Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans
Published in PLoS genetics (18-03-2019)“…Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes that control many cellular processes including development, cellular…”
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Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor
Published in ACS chemical biology (19-08-2016)“…Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce…”
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Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans
Published in Journal of the American Chemical Society (16-05-2012)“…Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining…”
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10
Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster
Published in Applied and Environmental Microbiology (01-04-2010)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
Published in PloS one (17-04-2017)“…The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions…”
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12
A Versatile and Efficient Gene-Targeting System for Aspergillus nidulans
Published in Genetics (Austin) (01-03-2006)“…Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as…”
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Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
Published in Molecular microbiology (01-10-2012)“…Summary Regulation of secondary metabolite (SM) gene clusters in Aspergillus nidulans has been shown to occur through cluster‐specific transcription factors or…”
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The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus
Published in Frontiers in microbiology (07-05-2020)“…In order for eukaryotes to efficiently detect and respond to environmental stimuli, a myriad of protein signaling pathways are utilized. An example of highly…”
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15
Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans
Published in Applied and Environmental Microbiology (01-12-2008)“…The sequencing of Aspergillus genomes has revealed that the products of a large number of secondary metabolism pathways have not yet been identified. This is…”
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Identification and analysis of essential Aspergillus nidulans genes using the heterokaryon rescue technique
Published in Nature protocols (01-12-2006)“…In the heterokaryon rescue technique, gene deletions are carried out using the pyrG nutritional marker to replace the coding region of target genes via…”
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Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
Published in Organic letters (16-11-2012)“…Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene…”
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18
Identification of the chaA and fwA Spore Color Genes of Aspergillus nidulans
Published in Journal of fungi (Basel) (01-02-2024)“…Wild-type asexual spores (conidia) are green due to a pigment that protects the spores against ultraviolet light. The pigment is produced by a biosynthetic…”
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Onychomycosis and its Chemotherapy
Published in Current medicinal chemistry (27-05-2016)“…Onychomycosis (fungal nail infections) is very common worldwide but is fortunately not often lethal. Several powerful drugs have been introduced into clinical…”
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Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases
Published in Organic letters (21-03-2014)“…A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed exchange of the starter unit ACP transacylase (SAT) domain in the…”
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