Search Results - "Oakley, Aaron J."

A structural view of bacterial DNA replication by Oakley, Aaron J.

“…DNA replication mechanisms are conserved across all organisms. The proteins required to initiate, coordinate, and complete the replication process are best…”
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Hidden Glutathione Transferases in the Human Genome by Oakley, Aaron J.

“…With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of…”
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Dynamics of Open DNA Sliding Clamps by Oakley, Aaron J

“…A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers. Clamps…”
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Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD by Newing, Timothy P., Oakley, Aaron J., Miller, Michael, Dawson, Catherine J., Brown, Simon H. J., Bouwer, James C., Tolun, Gökhan, Lewis, Peter J.

“…In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to…”
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Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli by Xu, Zhi-Qiang, Jergic, Slobodan, Lo, Allen T. Y., Pradhan, Alok C., Brown, Simon H. J., Bouwer, James C., Ghodke, Harshad, Lewis, Peter J., Tolun, Gökhan, Oakley, Aaron J., Dixon, Nicholas E.

“…Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader…”
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Replisome speed determines the efficiency of the Tus−Ter replication termination barrier by Elshenawy, Mohamed M., Jergic, Slobodan, Xu, Zhi-Qiang, Sobhy, Mohamed A., Takahashi, Masateru, Oakley, Aaron J., Dixon, Nicholas E., Hamdan, Samir M.

“…The Tus– Ter termination site of Escherichia coli is not completely efficient in stopping DNA replication, with about half of replisomes bypassing this…”
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Fragment-based screening by protein crystallography: successes and pitfalls by Chilingaryan, Zorik, Yin, Zhou, Oakley, Aaron J

“…Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These…”
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Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease by Bhatia, Surabhi, Knoch, Bianca, Wong, Jenny, Kim, Woojin S, Else, Paul L, Oakley, Aaron J, Garner, Brett

“…ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the…”
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Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site by Brock, Joseph, Board, Philip G, Oakley, Aaron J

“…Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are…”
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GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity by Menon, Deepthi, Innes, Ashlee, Oakley, Aaron J., Dahlstrom, Jane E., Jensen, Lora M., Brüstle, Anne, Tummala, Padmaja, Rooke, Melissa, Casarotto, Marco G., Baell, Jonathan B., Nguyen, Nghi, Xie, Yiyue, Cuellar, Matthew, Strasser, Jessica, Dahlin, Jayme L., Walters, Michael A., Burgio, Gaetan, O’Neill, Luke A. J., Board, Philip G.

“…Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of…”
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Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93 by Oakley, Aaron J, Bhatia, Surabhi, Ecroyd, Heath, Garner, Brett

“…Recent studies suggest reduction of radical-propagating fatty acid hydroperoxides to inert hydroxides by interaction with apolipoprotein-D (apoD) Met93 may…”
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Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses by Oakley, Aaron J, Barrett, Susan, Peat, Thomas S, Newman, Janet, Streltsov, Victor A, Waddington, Lynne, Saito, Takehiko, Tashiro, Masato, McKimm-Breschkin, Jennifer L

“…We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the neuraminidase (NA), which confers cross-resistance to all NA…”
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Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the α/β-hydrolase fold by Steiner, Roberto A, Janssen, Helge J, Roversi, Pietro, Oakley, Aaron J, Fetzner, Susanne

“…Enzymatic catalysis of oxygenation reactions in the absence of metal or organic cofactors is a considerable biochemical challenge. The CO-forming…”
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Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD by Larsen, Joachim S., Miller, Michael, Oakley, Aaron J., Dixon, Nicholas E., Lewis, Peter J.

“…Efficient control of transcription is essential in all organisms. In bacteria, where DNA replication and transcription occur simultaneously, the replication…”
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Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1 by Oakley, Aaron J.

“…Contamination of drinking water with toxic inorganic arsenic is a major public health issue. The mechanisms of enzymes and transporters in arsenic elimination…”
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The 2.0-Å Crystal Structure of eqFP611, a Far Red Fluorescent Protein from the Sea Anemone Entacmaea quadricolor by Petersen, Jan, Wilmann, Pascal G., Beddoe, Travis, Oakley, Aaron J., Devenish, Rodney J., Prescott, Mark, Rossjohn, Jamie

“…We have crystallized and subsequently determined to 2.0-Å resolution the crystal structure of eqFP611, a far red fluorescent protein from the sea anemone…”
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Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme by Udomsinprasert, Rungrutai, Pongjaroenkit, Saengtong, Wongsantichon, Jantana, Oakley, Aaron J, Prapanthadara, La-aied, Wilce, Matthew C J, Ketterman, Albert J

“…The insect GST (glutathione transferase) supergene family encodes a varied group of proteins belonging to at least six individual classes. Interest in insect…”
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The 2.2 Å Crystal Structure of a Pocilloporin Pigment Reveals a Nonplanar Chromophore Conformation by Prescott, Mark, Ling, Michael, Beddoe, Travis, Oakley, Aaron J., Dove, Sophie, Hoegh-Guldberg, Ove, Devenish, Rodney J., Rossjohn, Jamie

“…Reef-building corals contain host pigments, termed pocilloporins, that function to regulate the light environment of their resident microalgae by acting as a…”
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Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction by Chilingaryan, Zorik, Headey, Stephen J, Lo, Allen T Y, Xu, Zhi-Qiang, Otting, Gottfried, Dixon, Nicholas E, Scanlon, Martin J, Oakley, Aaron J

“…In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during…”
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Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden by Paiva, Leiliane, Marcos, Ricard, Creus, Amadeu, Coggan, Marjorie, Oakley, Aaron J, Board, Philip G

“…OBJECTIVES AND METHODSThe aim of this study was to investigate genetic variation in glutathione transferase omega 1 (GSTO1-1) in Atacameños, an indigenous…”
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