Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium

Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium

Summary Background & aims Measuring the nutritional status of trace elements in plasma is invalidated in the presence of a systemic inflammatory response. We examined the potential of erythrocytes to assess copper, zinc and selenium status in such situations. Methods Venous blood samples were wi...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Vol. 27; no. 1; pp. 115 - 120
Main Authors: Oakes, Eleanor J.C, Lyon, Thomas D.B, Duncan, Andrew, Gray, Andrew, Talwar, Dinesh, O’Reilly, Denis St.J
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01-02-2008
Elsevier
Subjects:
Acute Disease
Aged
Aged, 80 and over
Arthroplasty, Replacement, Knee
Biological and medical sciences
C-Reactive Protein - analysis
Copper
Copper - analysis
Copper - blood
Erythrocyte
Erythrocytes - chemistry
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Humans
Inflammation - blood
Inflammation - physiopathology
Iron - analysis
Iron - blood
Male
Micronutrient
Middle Aged
Nutritional Status
Selenium
Selenium - analysis
Selenium - blood
Serum Albumin - analysis
Trace Elements - analysis
Trace Elements - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Zinc
Zinc - analysis
Zinc - blood
Micronutrient
Erythrocyte
CRP
C-reactive protein
inductively coupled plasma mass spectrometry
Selenium
ICP-MS
Copper
Zinc
Nutritional status
Blood cell
Acute
Red blood cell
Metabolic diseases
Inflammation
Concentration
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Summary:Summary Background & aims Measuring the nutritional status of trace elements in plasma is invalidated in the presence of a systemic inflammatory response. We examined the potential of erythrocytes to assess copper, zinc and selenium status in such situations. Methods Venous blood samples were withdrawn pre-operatively and at 12, 24, 48, 72 and 168 h post-operatively from 11 patients (6 males and 5 females) who were admitted for elective knee arthroplasty. C-reactive protein, albumin, copper, zinc, selenium and iron were measured in plasma and erythrocytes. Results Plasma zinc and selenium concentrations fell significantly: 95% confidence intervals (CI)=−32% to −44% and −22% to −36%, respectively. Copper concentrations fell transiently and then increased significantly: CI=12–43%. No significant changes were seen in trace element concentrations in erythrocytes expressed either as a ratio of haemoglobin or iron concentration. Erythrocyte iron levels correlated significantly with haemoglobin ( r =0.93). Conclusions Plasma concentrations of copper, zinc and selenium are unreliable markers of status in patients with an acute inflammatory response. Erythrocyte concentrations of these trace elements may provide a more reliable measure in long-term studies of patients with a chronic systemic inflammatory response. Iron can be used instead of haemoglobin as the denominator when expressing erythrocyte concentrations of trace elements.
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ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2007.10.003