Search Results - "Oakes, A"

The Role of Endoplasmic Reticulum Stress in Human Pathology by Oakes, Scott A, Papa, Feroz R

“…Numerous genetic and environmental insults impede the ability of cells to properly fold and posttranslationally modify secretory and transmembrane proteins in…”
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TBK1: a new player in ALS linking autophagy and neuroinflammation by Oakes, James A, Davies, Maria C, Collins, Mark O

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder affecting motor neurons, resulting in progressive muscle weakness and death by…”
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Signaling cell death from the endoplasmic reticulum stress response by Shore, Gordon C, Papa, Feroz R, Oakes, Scott A

“…Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both…”
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Quantum cosmology with dynamical vacuum in a minimal-length scenario by Gusson, M. F., Gonçalves, A. Oakes O., Furtado, R. G., Fabris, J. C., Nogueira, J. A.

“…In this work, we consider effects of the dynamical vacuum in quantum cosmology in presence of a minimum length introduced by the GUP (generalized uncertainty…”
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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress by Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.

“…When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded…”
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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress by Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.

“…Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER…”
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Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients by Crane, Courtney A., Austgen, Kathryn, Haberthur, Kristen, Hofmann, Carly, Moyes, Kara White, Avanesyan, Lia, Fong, Lawrence, Campbell, Michael J., Cooper, Stewart, Oakes, Scott A., Parsa, Andrew T., Lanier, Lewis L.

“…Myeloid cells are key regulators of the tumor microenvironment, governing local immune responses. Here we report that tumor-infiltrating myeloid cells and…”
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Endoplasmic Reticulum Stress Signaling in Cancer Cells by Oakes, Scott A.

“…To survive, cancer cells must resist numerous internal and environmental insults associated with neoplasia that jeopardize proteostasis within the endoplasmic…”
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Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4 by Steffen, Kristan K., MacKay, Vivian L., Kerr, Emily O., Tsuchiya, Mitsuhiro, Hu, Di, Fox, Lindsay A., Dang, Nick, Johnston, Elijah D., Oakes, Jonathan A., Tchao, Bie N., Pak, Diana N., Fields, Stanley, Kennedy, Brian K., Kaeberlein, Matt

“…In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the…”
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Akt and autophagy cooperate to promote survival of drug-resistant glioma by Fan, Qi-Wen, Cheng, Christine, Hackett, Chris, Feldman, Morri, Houseman, Benjamin T, Nicolaides, Theodore, Haas-Kogan, Daphne, James, C David, Oakes, Scott A, Debnath, Jayanta, Shokat, Kevan M, Weiss, William A

“…Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and…”
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Safety of Transesophageal Echocardiography by Hilberath, Jan N., MD, Oakes, Daryl A., MD, Shernan, Stanton K., MD, Bulwer, Bernard E., MD, D’Ambra, Michael N., MD, Eltzschig, Holger K., MD, PhD

“…Since its introduction into the operating room in the early 1980s, transesophageal echocardiography (TEE) has gained widespread use during cardiac, major…”
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BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis by Scorrano, Luca, Oakes, Scott A., Opferman, Joseph T., Cheng, Emily H., Sorcinelli, Mia D., Pozzan, Tullio, Korsmeyer, Stanley J.

“…BAX and BAK are "multidomain" proapoptotic proteins that initiate mitochondrial dysfunction but also localize to the endoplasmic reticulum (ER). Mouse…”
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Trends in computer navigation and robotic assistance for total knee arthroplasty in the United States: an analysis of patient and hospital factors by Antonios, Joseph K., Korber, Shane, Sivasundaram, Lakshmanan, Mayfield, Cory, Kang, Hyunwoo Paco, Oakes, Daniel A., Heckmann, Nathanael D.

“…Computer navigation and robotic assistance technologies are used to improve the accuracy of component positioning in total knee arthroplasty (TKA), with the…”
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Fast High-Fidelity Single-Shot Readout of Spins in Silicon Using a Single-Electron Box by Oakes, G. A., Ciriano-Tejel, V. N., Wise, D. F., Fogarty, M. A., Lundberg, T., Lainé, C., Schaal, S., Martins, F., Ibberson, D. J., Hutin, L., Bertrand, B., Stelmashenko, N., Robinson, J. W. A., Ibberson, L., Hashim, A., Siddiqi, I., Lee, A., Vinet, M., Smith, C. G., Morton, J. J. L., Gonzalez-Zalba, M. F.

“…Three key metrics for readout systems in quantum processors are measurement speed, fidelity, and footprint. Fast high-fidelity readout enables midcircuit…”
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Proapoptotic BAX and BAK Regulate the Type 1 Inositol Trisphosphate Receptor and Calcium Leak from the Endoplasmic Reticulum by Oakes, Scott A., Scorrano, Luca, Opferman, Joseph T., Bassik, Michael C., Nishino, Mari, Pozzan, Tullio, Korsmeyer, Stanley J.

“…Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic…”
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Dirac δ-function potential in quasiposition representation of a minimal-length scenario by Gusson, M. F., Gonçalves, A. Oakes O., Francisco, R. O., Furtado, R. G., Fabris, J. C., Nogueira, J. A.

“…A minimal-length scenario can be considered as an effective description of quantum gravity effects. In quantum mechanics the introduction of a minimal length…”
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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis by Scorrano, Luca, Ashiya, Mona, Buttle, Karolyn, Weiler, Solly, Oakes, Scott A., Mannella, Carmen A., Korsmeyer, Stanley J.

“…The mechanism during apoptosis by which cytochrome c is rapidly and completely released in the absence of mitochondrial swelling is uncertain. Here, we show…”
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Awakening after cardiac arrest and post resuscitation hypothermia: Are we pulling the plug too early? by Gold, Barbara, Puertas, Laura, Davis, Scott P, Metzger, Anja, Yannopoulos, Demetris, Oakes, Dana A, Lick, Charles J, Gillquist, Debbie L, Holm, Susie Y. Osaki, Olsen, John D, Jain, Sandeep, Lurie, Keith G

“…Abstract Background Time to awakening after out-of-hospital cardiac arrest (OHCA) and post-resuscitation therapeutic hypothermia (TH) varies widely. We…”
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Proteostasis control by the unfolded protein response by Hetz, Claudio, Chevet, Eric, Oakes, Scott A.

“…Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with…”
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Inter-subject correlation of audience facial expressions predicts audience engagement during theatrical performances by Oakes, Richard A., Peschel, Lisa, Barraclough, Nick E.

“…During performances, audiences experience various emotional states, and these are reflected in their ongoing facial expressions. We investigated if audience…”
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