The effects of zoledronic acid and hyperbaric oxygen on posterior lumbar fusion in a rabbit model

We studied the effects of hyperbaric oxygen (HBO) and zoledronic acid (ZA) on posterior lumbar fusion using a validated animal model. A total of 40 New Zealand white rabbits underwent posterior lumbar fusion at L5-6 with autogenous iliac bone grafting. They were divided randomly into four groups as...

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Bibliographic Details
Published in:	Journal of bone and joint surgery. British volume Vol. 93; no. 6; pp. 793 - 800
Main Authors:	YALCIN, N, OZTIIRK, A, OZKAN, Y, CELIMLI, N, OZOCAK, E, ERDOGAN, A, AHIN, N, ILGEZDI, S
Format:	Journal Article
Language:	English
Published:	London British Editorial Society of Bone and Joint Surgery 01-06-2011
Subjects:	Animals Biological and medical sciences Bone Density Conservation Agents - therapeutic use Bone Transplantation - methods Bones, joints and connective tissue. Antiinflammatory agents Diphosphonates - therapeutic use Disease Models, Animal Diseases of the osteoarticular system Hyperbaric Oxygenation - methods Ilium - transplantation Imidazoles - therapeutic use Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - physiology Male Medical sciences Orthopedic surgery Palpation Pharmacology. Drug treatments Rabbits Radiography Spinal Fusion - methods Stress, Mechanical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome Antiosteoporotic Lumbar spine Hyperbaric oxygen Antiresorptive agent Rabbit Diphosphonic acid derivatives Lagomorpha Bisphosphonates Vertebrata Mammalia Orthopedic surgery Treatment Antiosteoclastic agent Animal Posterior Zoledronic acid Models
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Summary:	We studied the effects of hyperbaric oxygen (HBO) and zoledronic acid (ZA) on posterior lumbar fusion using a validated animal model. A total of 40 New Zealand white rabbits underwent posterior lumbar fusion at L5-6 with autogenous iliac bone grafting. They were divided randomly into four groups as follows: group 1, control; group 2, HBO (2.4 atm for two hours daily); group 3, local ZA (20 μg of ZA mixed with bone graft); and group 4, combined HBO and local ZA. All the animals were killed six weeks after surgery and the fusion segments were subjected to radiological analysis, manual palpation, biomechanical testing and histological examination. Five rabbits died within two weeks of operation. Thus, 35 rabbits (eight in group 1 and nine in groups 2, 3 and 4) completed the study. The rates of fusion in groups 3 and 4 (p = 0.015) were higher than in group 1 (p < 0.001) in terms of radiological analysis and in group 4 was higher than in group 1 with regard to manual palpation (p = 0.015). We found a statistically significant difference in the biomechanical analysis between groups 1 and 4 (p = 0.024). Histological examination also showed a statistically significant difference between groups 1 and 4 (p = 0.036). Our results suggest that local ZA combined with HBO may improve the success rate in posterior lumbar spinal fusion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0301-620X 2044-5377
DOI:	10.1302/0301-620X.93B6.24257