Search Results - "OYAMA, TETSUNARI"

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages by Takahashi, Hideyuki, Sakakura, Koichi, Kudo, Takeshi, Toyoda, Minoru, Kaira, Kyoichi, Oyama, Tetsunari, Chikamatsu, Kazuaki

“…Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated…”
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Correlation of L‐type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis by Furuya, Mio, Horiguchi, Jun, Nakajima, Hiroki, Kanai, Yoshikatsu, Oyama, Tetsunari

“…Triple negative breast cancer (TNBC) is a heterogeneous, aggressive cancer for which there is no effective chemotherapy or targeted therapy. We aimed to…”
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Histologic assessment of tumor budding in preoperative biopsies to predict nodal metastasis in squamous cell carcinoma of the tongue and floor of the mouth by Seki, Mai, Sano, Takaaki, Yokoo, Satoshi, Oyama, Tetsunari

“…Background In squamous cell carcinoma (SCC) of the tongue and the floor of the mouth (FOM), it is important to predict lymph node metastasis, including occult…”
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FDG uptake reflects breast cancer immunological features: the PD-L1 expression and degree of TILs in primary breast cancer by Hirakata, Tomoko, Fujii, Takaaki, Kurozumi, Sasagu, Katayama, Ayaka, Honda, Chikako, Yanai, Keiko, Tokuda, Shoko, Nakazawa, Yuko, Obayashi, Sayaka, Yajima, Reina, Kaira, Kyoichi, Oyama, Tetsunari, Shirabe, Ken

“…Background High F18-fluorodeoxyglucose (FDG) uptake has been reported to be a predictor of poor prognosis in patients with breast cancer. We investigated the…”
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Prognostic utility of tumor-infiltrating lymphocytes in residual tumor after neoadjuvant chemotherapy with trastuzumab for HER2-positive breast cancer by Kurozumi, Sasagu, Inoue, Kenichi, Matsumoto, Hiroshi, Fujii, Takaaki, Horiguchi, Jun, Oyama, Tetsunari, Kurosumi, Masafumi, Shirabe, Ken

“…Predictive utility of tumor-infiltrating lymphocytes (TILs) in HER2-positive breast cancer patients receiving neoadjuvant chemotherapy (NAC) with concurrent…”
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Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer by Kurozumi, Sasagu, Kaira, Kyoichi, Matsumoto, Hiroshi, Kurosumi, Masafumi, Yokobori, Takehiko, Kanai, Yoshikatsu, Sekine, Chikako, Honda, Chikako, Katayama, Ayaka, Furuya, Mio, Shiino, Sho, Makiguchi, Takaya, Mongan, Nigel P., Rakha, Emad A., Oyama, Tetsunari, Fujii, Takaaki, Shirabe, Ken, Horiguchi, Jun

“…L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor metabolism and be associated with tumor proliferation. In…”
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Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling by Dolgormaa, Gantumur, Harimoto, Norifumi, Ishii, Norihiro, Yamanaka, Takahiro, Hagiwara, Kei, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Handa, Tadashi, Yokobori, Takehiko, Oyama, Tetsunari, Kuwano, Hiroyuki, Shirabe, Ken

“…Background Wisteria floribunda agglutinin (WFA) + Mac-2-binding protein (M2BPGi) is a novel serum marker for liver fibrosis. Although an elevated serum level…”
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Clinicopathological values of PD-L1 expression in HER2-positive breast cancer by Kurozumi, Sasagu, Inoue, Kenichi, Matsumoto, Hiroshi, Fujii, Takaaki, Horiguchi, Jun, Oyama, Tetsunari, Kurosumi, Masafumi, Shirabe, Ken

“…Several ongoing clinical trials are investigating the use of immuno-targeting therapy with programmed cell death protein-1 and programmed death-ligand 1…”
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Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice by Kobayashi, Ryosuke, Kawabata‐Iwakawa, Reika, Sugiyama, Makoto, Oyama, Tetsunari, Ohtsuka, Masato, Horii, Takuro, Morita, Sumiyo, Nishiyama, Masahiko, Hatada, Izuho

“…Synergistic effects among multiple gene mutations are involved in cancer development and progression. However, developing genetically modified mouse models to…”
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Predictors of pathological complete response to neoadjuvant treatment and changes to post-neoadjuvant HER2 status in HER2-positive invasive breast cancer by Katayama, Ayaka, Miligy, Islam M., Shiino, Sho, Toss, Michael S., Eldib, Karim, Kurozumi, Sasagu, Quinn, Cecily M., Badr, Nahla, Murray, Ciara, Provenzano, Elena, Callagy, Grace, Martyn, Cian, Millican-Slater, Rebecca, Purdie, Colin, Purnell, Dave, Pinder, Sarah E., Oyama, Tetsunari, Shaaban, Abeer M., Ellis, Ian, Lee, Andrew H.S., Rakha, Emad A.

“…The response of human epidermal growth factor receptor2 (HER2)- positive breast cancer (BC) patients to anti-HER2 targeted therapy is significant. However, the…”
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AKT3 is a key regulator of head and neck squamous cell carcinoma by Takahashi, Hideyuki, Rokudai, Susumu, Kawabata‐Iwakawa, Reika, Sakakura, Koichi, Oyama, Tetsunari, Nishiyama, Masahiko, Chikamatsu, Kazuaki

“…The phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a vital role in cell proliferation, apoptosis, metabolism, and…”
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Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment by Sakakura, Koichi, Takahashi, Hideyuki, Kaira, Kyoichi, Toyoda, Minoru, Murata, Takaaki, Ohnishi, Hiroshi, Oyama, Tetsunari, Chikamatsu, Kazuaki

“…Tumor-associated macrophages (TAM) have been classified into an immunostimulatory M1 subset against microbes and malignancies, and an immunoregulatory M2…”
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Expression of L‐type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma by Isoda, Atsushi, Kaira, Kyoichi, Iwashina, Masanori, Oriuchi, Noboru, Tominaga, Hideyuki, Nagamori, Shushi, Kanai, Yoshikatsu, Oyama, Tetsunari, Asao, Takayuki, Matsumoto, Morio, Sawamura, Morio

“…L‐type amino‐acid transporter 1 (LAT1) plays a key role in cell growth and survival. To determine the prognostic significance of LAT1 in multiple myeloma (MM),…”
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In vitro assessment of antitumor immune responses using tumor antigen proteins produced by transgenic silkworms by Yamada, Kanae, Masuda, Kei, Ida, Shota, Tada, Hiroe, Bando, Minori, Abe, Kanako, Tatematsu, Ken-ichiro, Sezutsu, Hideki, Oyama, Tetsunari, Chikamatsu, Kazuaki, Takeda, Shigeki

“…The evaluation of antitumor immune responses is essential for immune monitoring to predict clinical outcomes as well as treatment efficacies in cancer…”
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Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma by Sakakura, Koichi, Takahashi, Hideyuki, Kaira, Kyoichi, Toyoda, Minoru, Oyama, Tetsunari, Chikamatsu, Kazuaki

“…The immunological significance of autophagy in the tumor microenvironment remains unclear. To explore the relationship between autophagy and anti‐tumor immune…”
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Power of PgR expression as a prognostic factor for ER-positive/HER2-negative breast cancer patients at intermediate risk classified by the Ki67 labeling index by Kurozumi, Sasagu, Matsumoto, Hiroshi, Hayashi, Yuji, Tozuka, Katsunori, Inoue, Kenichi, Horiguchi, Jun, Takeyoshi, Izumi, Oyama, Tetsunari, Kurosumi, Masafumi

“…The Ki67 labeling index (LI) is regarded as a significant prognostic marker in ER-positive/HER2-negative breast cancer patients. The expression of PgR has…”
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High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence by Muranushi, Ryo, Araki, Kenichiro, Yokobori, Takehiko, Chingunjav, Batbayar, Hoshino, Kouki, Dolgormaa, Gantumur, Hagiwara, Kei, Yamanaka, Takahiro, Ishii, Norihiro, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Harimoto, Norifumi, Shimoda, Yuki, Sano, Rie, Oyama, Tetsunari, Saeki, Hiroshi, Shirabe, Ken

“…CKLF‐like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD‐L1 expression by controlling its endosomal recycling. However, in…”
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Impact of combining the progesterone receptor and preoperative endocrine prognostic index (PEPI) as a prognostic factor after neoadjuvant endocrine therapy using aromatase inhibitors in postmenopausal ER positive and HER2 negative breast cancer by Kurozumi, Sasagu, Matsumoto, Hiroshi, Inoue, Kenichi, Tozuka, Katsunori, Hayashi, Yuji, Kurosumi, Masafumi, Oyama, Tetsunari, Fujii, Takaaki, Horiguchi, Jun, Kuwano, Hiroyuki

“…The preoperative endocrine prognostic index (PEPI) predicts survival after neoadjuvant endocrine therapy (NAE) using aromatase inhibitors (AIs) for women with…”
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FDG-PET reflects tumor viability on SUV in colorectal cancer liver metastasis by Watanabe, Akira, Harimoto, Norifumi, Yokobori, Takehiko, Araki, Kenichiro, Kubo, Norio, Igarashi, Takamichi, Tsukagoshi, Mariko, Ishii, Norihiro, Yamanaka, Takahiro, Handa, Tadashi, Oyama, Tetsunari, Higuchi, Tetsuya, Shirabe, Ken

“…Background Liver resection is the most effective procedure for colorectal cancer liver metastasis (CRLM); however, early recurrence is an important problem…”
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Dynamic alterations of circulating T lymphocytes and the clinical response in patients with head and neck squamous cell carcinoma treated with nivolumab by Tada, Hiroe, Takahashi, Hideyuki, Yamada, Kanae, Masuda, Kei, Nagata, Yurino, Uchida, Miho, Shino, Masato, Ida, Shota, Mito, Ikko, Matsuyama, Toshiyuki, Oyama, Tetsunari, Tatematsu, Ken-Ichiro, Sezutsu, Hideki, Takeda, Shigeki, Chikamatsu, Kazuaki

“…Cancer immunotherapy using immune checkpoint inhibitors (ICIs) has been recognized as a novel therapeutic option for head and neck squamous cell carcinoma…”
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