Search Results - "OWEN, M.J"

S.06.01 Copy number variations as risk and protective factors for schizophrenia in 22q11.2DS by Van den Bree, M.B.M, Cunningham, A.C, Owen, M.J

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Neuropsychological effects of the CSMD1 genome‐wide associated schizophrenia risk variant rs10503253 by Donohoe, G., Walters, J., Hargreaves, A., Rose, E.J., Morris, D.W., Fahey, C., Bellini, S., Cummins, E., Giegling, I., Hartmann, A.M., Möller, H.‐J., Muglia, P., Owen, M.J., Gill, M., O'Donovan, M.C., Tropea, D., Rujescu, D., Corvin, A.

“…The single‐nucleotide polymorphism (SNP) rs10503253, located within the CUB and Sushi multiple domains‐1 (CSMD1) gene on 8p23.2, was recently identified as…”
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Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia by Carroll, L.S., Williams, H.J., Walters, J., Kirov, G., O'Donovan, M.C., Owen, M.J.

“…Deletion of chromosome 3q29, which is associated with mental retardation and autism, was recently identified as being present in excess or occurring de novo in…”
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Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia by Mundlos, S, Otto, F, Mundlos, C, Mulliken, J.B, Aylsworth, A.S, Albright, S, Lindhout, D, Cole, W.G, Henn, W, Knoll, J.H.M, Owen, M.J, Mertelsmann, R, Zabel, B.U, Olsen, B.R

“…Cleidocranial dysplasia (CCD) is an autosomal-dominant condition characterized by hypoplasia/aplasia of clavicles, patent fontanelles, supernumerary teeth,…”
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S.16.02 Schizophrenia and the neurodevelopmental continuum; new support from genomics by Owen, M.J.

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P.4.016 Follow-up of schizophrenia genome-wide association studies implicates the MHC region in cognition by Walters, J, O'Donovan, M.C, Giegling, I, Rujescu, D, Owen, M.J

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Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease by Morgan, A.R., Hamilton, G., Turic, D., Jehu, L., Harold, D., Abraham, R., Hollingworth, P., Moskvina, V., Brayne, C., Rubinsztein, D.C., Lynch, A., Lawlor, B., Gill, M., O'Donovan, M., Powell, J., Lovestone, S., Williams, J., Owen, M.J.

“…Late‐onset Alzheimer's disease (LOAD) is a genetically complex neurodegenerative disorder. Currently, only the ε4 allele of the Apolipoprotein E gene has been…”
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Hydrophobicity loss and recovery of silicone HV insulation by Kim, J, Chaudhury, M K, Owen, M J

“…Most of the silicone materials used for HV outdoor insulation are high-consistency, heat cured polydimethylsiloxane (PDMS) elastomers. The unique properties of…”
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The p24 family member p23 is required for early embryonic development by Denzel, A., Otto, F., Girod, A., Pepperkok, R., Watson, R., Rosewell, I., Bergeron, J.J.M., Solarie, R.C.E., Owen, M.J.

“…The p24 family of type I integral-membrane proteins, which are localised in the endoplasmic reticulum (ER) [1–3], the intermediate compartment and the Golgi…”
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An examination of MUTED as a schizophrenia susceptibility gene by Gerrish, A, Williams, H, Moskvina, V, Owen, M.J, O'Donovan, M.C, Williams, N.M

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Association analysis of the glial cell line-derived neurotrophic factor ( GDNF ) gene in schizophrenia by Williams, H.J, Norton, N, Peirce, T, Dwyer, S, Williams, N.M, Moskvina, V, Owen, M.J, O'Donovan, M.C

“…Abstract The glial cell line-derived neurotrophic factor (GDNF) gene is located within a region of chromosome 5 (5p14.1–q13.3) that has been highlighted as a…”
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Expanded CAG repeats in schizophrenia and bipolar disorder by O'Donovan, M.C, Guy, C, Craddock, N, Murphy, K.C, Cardno, A.G, Jones, L.A, Owen, M.J, McGuffin, P

“…Recent studies have supported an old proposal that anticipation occurs in multiplex families transmitting schizophrenia and bipolar disorder. While the…”
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Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder by Børglum, A.D., Kirov, G., Craddock, N., Mors, O., Muir, W., Murray, V., McKee, I., Collier, D.A., Ewald, H., Owen, M.J., Blackwood, D., Kruse, T.A.

“…Dopa decarboxylase (DDC) catalyses the synthesis of both dopamine and serotonin as well as trace amines suggested to possess neuromodulating capabilities. We…”
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Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior by Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M.B.M., Craddock, N., Kent, L., Owen, M.J., O'Donovan, M.C., Thapar, A.

“…Gene × environment (G × E) interactions are increasingly thought to have substantial influence on the aetiology and clinical manifestations of complex…”
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Evaluating historical candidate genes for schizophrenia by Farrell, M S, Werge, T, Sklar, P, Owen, M J, Ophoff, R A, O'Donovan, M C, Corvin, A, Cichon, S, Sullivan, P F

“…Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the…”
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European multicentre association study of schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms by Spurlock, G., Williams, J., McGuffin, P., Aschauer, H.N., Lenzinger, E., Fuchs, K., Sieghart, W.C., Meszaros, K., Fathi, N., Laurent, C., Mallet, J., Macciardi, F., Pedrini, S., Gill, M., Hawi, Z., Gibson, S., Jazin, E.E., Yang, Hai-Tao, Adolfsson, R., Pato, C.N., Dourado, A.M., Owen, M.J.

“…As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The…”
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Copy number variation in bipolar disorder by Green, E K, Rees, E, Walters, J T R, Smith, K-G, Forty, L, Grozeva, D, Moran, J L, Sklar, P, Ripke, S, Chambert, K D, Genovese, G, McCarroll, S A, Jones, I, Jones, L, Owen, M J, O'Donovan, M C, Craddock, N, Kirov, G

“…Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar…”
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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia by Kirov, G, Pocklington, A J, Holmans, P, Ivanov, D, Ikeda, M, Ruderfer, D, Moran, J, Chambert, K, Toncheva, D, Georgieva, L, Grozeva, D, Fjodorova, M, Wollerton, R, Rees, E, Nikolov, I, van de Lagemaat, L N, Bayés, À, Fernandez, E, Olason, P I, Böttcher, Y, Komiyama, N H, Collins, M O, Choudhary, J, Stefansson, K, Stefansson, H, Grant, S G N, Purcell, S, Sklar, P, O'Donovan, M C, Owen, M J

“…A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of…”
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Common alleles contribute to schizophrenia in CNV carriers by Tansey, K E, Rees, E, Linden, D E, Ripke, S, Chambert, K D, Moran, J L, McCarroll, S A, Holmans, P, Kirov, G, Walters, J, Owen, M J, O'Donovan, M C

“…The genetic architecture of schizophrenia is complex, involving risk alleles ranging from common alleles of weak effect to rare alleles of large effect, the…”
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Copy number variation in schizophrenia in Sweden by Szatkiewicz, J P, O'Dushlaine, C, Chen, G, Chambert, K, Moran, J L, Neale, B M, Fromer, M, Ruderfer, D, Akterin, S, Bergen, S E, Kähler, A, Magnusson, P K E, Kim, Y, Crowley, J J, Rees, E, Kirov, G, O'Donovan, M C, Owen, M J, Walters, J, Scolnick, E, Sklar, P, Purcell, S, Hultman, C M, McCarroll, S A, Sullivan, P F

“…Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of…”
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