Search Results - "OVERDUIN, Michael"

Membranes are functionalized by a proteolipid code by Kervin, Troy A, Overduin, Michael

“…Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are…”
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Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer's Disease by Grant, Paige, Kumar, Jitendra, Kar, Satyabrata, Overduin, Michael

“…Alzheimer's disease (AD) is the most common cause of dementia worldwide. Despite extensive research and targeting of the main molecular components of the…”
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Membrane protein architects: the role of the BAM complex in outer membrane protein assembly by Henderson, Ian R, Knowles, Timothy J, Scott-Tucker, Anthony, Overduin, Michael

“…Key Points The Gram-negative outer membrane protein (OMP) family includes proteins that are associated with basic physiological functions, virulence and…”
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Membrane Proteins Solubilized Intact in Lipid Containing Nanoparticles Bounded by Styrene Maleic Acid Copolymer by Knowles, Timothy J, Finka, Rachael, Smith, Corinne, Lin, Yu-Pin, Dafforn, Tim, Overduin, Michael

“…One-third of eukaryotic proteins are integrated within membranes, as are the targets of 40% of approved drugs. However, the lack of a general means of…”
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Mechanistic Basis of Desmosome-Targeted Diseases by Al-Jassar, Caezar, Bikker, Hennie, Overduin, Michael, Chidgey, Martyn

“…Desmosomes are dynamic junctions between cells that maintain the structural integrity of skin and heart tissues by withstanding shear forces. Mutations in…”
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Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins by Jamshad, Mohammed, Grimard, Vinciane, Idini, Ilaria, Knowles, Tim J., Dowle, Miriam R., Schofield, Naomi, Sridhar, Pooja, Lin, Yupin, Finka, Rachael, Wheatley, Mark, Thomas, Owen R. T., Palmer, Richard E., Overduin, Michael, Govaerts, Cédric, Ruysschaert, Jean-Marie, Edler, Karen J., Dafforn, Tim R.

“…In the past few years there has been a growth in the use of nanoparticles for stabilizing lipid membranes that contain embedded proteins. These…”
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Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting by Lenoir, Marc, Ustunel, Cansel, Rajesh, Sandya, Kaur, Jaswant, Moreau, Dimitri, Gruenberg, Jean, Overduin, Michael

“…Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to…”
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Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX by Bissig, Christin, Lenoir, Marc, Velluz, Marie-Claire, Kufareva, Irina, Abagyan, Ruben, Overduin, Michael, Gruenberg, Jean

“…ALIX plays a role in nucleocapsid release during viral infection, as does lysobisphosphatidic acid (LBPA). However, the mechanism remains unclear. Here we…”
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Native Nanodiscs and the Convergence of Lipidomics, Metabolomics, Interactomics and Proteomics by Overduin, Michael, Esmaili, Mansoore

“…The omics disciplines remain largely distinct sciences due to the necessity of separating molecular classes for different assays. For example, water-soluble…”
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Detergent-free purification of ABC (ATP-binding-cassette) transporters by Gulati, Sonali, Jamshad, Mohammed, Knowles, Timothy J, Morrison, Kerrie A, Downing, Rebecca, Cant, Natasha, Collins, Richard, Koenderink, Jan B, Ford, Robert C, Overduin, Michael, Kerr, Ian D, Dafforn, Timothy R, Rothnie, Alice J

“…ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these…”
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Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila by Brombacher, Eva, Urwyler, Simon, Ragaz, Curdin, Weber, Stefan S., Kami, Keiichiro, Overduin, Michael, Hilbi, Hubert

“…The causative agent of Legionnaires disease, Legionella pneumophila, forms a replicative vacuole in phagocytes by means of the intracellular…”
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The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses by Gräßel, Linda, Fast, Laura Aline, Scheffer, Konstanze D., Boukhallouk, Fatima, Spoden, Gilles A., Tenzer, Stefan, Boller, Klaus, Bago, Ruzica, Rajesh, Sundaresan, Overduin, Michael, Berditchevski, Fedor, Florin, Luise

“…Human papillomaviruses enter host cells via a clathrin-independent endocytic pathway involving tetraspanin proteins. However, post-endocytic trafficking…”
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Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers by Kervin, Troy A., Overduin, Michael

“…The genetic code that dictates how nucleic acids are translated into proteins is well known, however, the code through which proteins recognize membranes…”
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Progressive membrane-binding mechanism of SARS-CoV-2 variant spike proteins by Overduin, Michael, Kervin, Troy A., Tran, Anh

“…Membrane recognition by viral spike proteins is critical for infection. Here we show the host cell membrane-binding surfaces of severe acute respiratory…”
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Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily by Lenoir, Marc, Kufareva, Irina, Abagyan, Ruben, Overduin, Michael

“…The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module…”
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SARS-CoV-2 Omicron Subvariants Balance Host Cell Membrane, Receptor, and Antibody Docking via an Overlapping Target Site by Overduin, Michael, Bhat, Rakesh K, Kervin, Troy A

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are emerging rapidly and offer surfaces that are optimized for recognition of host…”
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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments by Guix, Francesc X, Sannerud, Ragna, Berditchevski, Fedor, Arranz, Amaia M, Horré, Katrien, Snellinx, An, Thathiah, Amantha, Saido, Takaomi, Saito, Takashi, Rajesh, Sundaresan, Overduin, Michael, Kumar-Singh, Samir, Radaelli, Enrico, Corthout, Nikky, Colombelli, Julien, Tosi, Sébastien, Munck, Sebastian, Salas, Isabel H, Annaert, Wim, De Strooper, Bart

“…The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer's disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ…”
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Multifaceted membrane binding head of the SARS-CoV-2 spike protein by Tran, Anh, Kervin, Troy A., Overduin, Michael

“…The SARS-CoV-2 spike protein presents a surface with enormous membrane binding potential to host tissues and organelles of infected cells. Its exposed trimeric…”
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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy by Chan, Jordan S.F., Tabatabaei Dakhili, Seyed Amirhossein, Lorenzana-Carrillo, Maria Areli, Gopal, Keshav, Pulente, Serena M., Greenwell, Amanda A., Yang, Kunyan, Saed, Christina T., Stenlund, Magnus J., Ferrari, Sally R., Mangra-Bala, Indiresh A., Shafaati, Tanin, Bhat, Rakesh K., Eaton, Farah, Overduin, Michael, Jørgensen, Sebastian Beck, Steinberg, Gregory R., Mulvihill, Erin E., Sutendra, Gopinath, Ussher, John R.

“…Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the…”
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Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin by Fogl, Claudia, Mohammed, Fiyaz, Al-Jassar, Caezar, Jeeves, Mark, Knowles, Timothy J., Rodriguez-Zamora, Penelope, White, Scott A., Odintsova, Elena, Overduin, Michael, Chidgey, Martyn

“…Plakin proteins form critical connections between cell junctions and the cytoskeleton; their disruption within epithelial and cardiac muscle cells cause…”
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