Search Results - "OVERBERGH, L."

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity by Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E

“…Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce…”
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Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations by Bensellam, M., Van Lommel, L., Overbergh, L., Schuit, F. C., Jonas, J. C.

“…Aims/hypothesis Survival and function of insulin-secreting pancreatic beta cells are markedly altered by changes in nutrient availability. In vitro, culture in…”
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Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance by Maris, M., Overbergh, L., Gysemans, C., Waget, A., Cardozo, A. K., Verdrengh, E., Cunha, J. P. M., Gotoh, T., Cnop, M., Eizirik, D. L., Burcelin, R., Mathieu, C.

“…Aims/hypothesis Endoplasmic reticulum (ER) stress has been implicated in the development of type 2 diabetes, via effects on obesity, insulin resistance and…”
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Glucagon-like peptide-1: modulator of β-cell dysfunction and death by Rondas, D., D'Hertog, W., Overbergh, L., Mathieu, C.

“…Glucagon‐like peptide‐1 (GLP‐1) is one of the hormones responsible for the incretin effect, a term that refers to the observation that orally administered…”
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Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice by GIULIETTI, A, GYSEMANS, C, STOFFELS, K, VAN ETTEN, E, DECALLONNE, B, OVERBERGH, L, BOUILLON, R, MATHIEU, C

“…1,25-dihydroxyvitamin D(3), the active form of vitamin D, prevents Type 1 diabetes in non-obese diabetic (NOD) mice. Epidemiological data show a threefold…”
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Unraveling the effects of 1,25(OH)2D3 on global gene expression in pancreatic islets by Wolden-Kirk, H., Overbergh, L., Gysemans, C., Brusgaard, K., Naamane, N., Van Lommel, L., Schuit, F., Eizirik, D.L., Christesen, H., Mathieu, C.

“…▸ We investigate the effects of 1,25(OH)2D3 on global gene expression in pancreatic islets. ▸ Cytoskeletal and intracellular trafficking genes are induced by…”
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Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients by Truyen, E, Coteur, L, Dilissen, E, Overbergh, L, Dupont, L J, Ceuppens, J L, Bullens, D M A

“…Background: Asthma is a chronic inflammatory disorder of the airways driven by T cell activation. Th2 cells and their cytokines are thought to play a role in…”
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Early up‐regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model by CHEN, L., MARTINEZ, O., OVERBERGH, L., MATHIEU, C., PRABHAKAR, B. S., CHAN, L. S.

“…SUMMARY We investigated cytokine profiles in interleukin (IL)‐4 transgenic (Tg) mice with a skin inflammatory disease resembling human atopic dermatitis. cDNA…”
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Immune regulation of 1α-hydroxylase in murine peritoneal macrophages: Unravelling the IFNγ pathway by Stoffels, K., Overbergh, L., Bouillon, R., Mathieu, C.

“…The activated form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), plays an important role in the immune system. Indeed, receptors for 1,25(OH)2D3 are…”
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The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression by Overbergh, L, Giulietti, A, Valckx, D, Decallonne, R, Bouillon, R, Mathieu, C

“…Real-time reverse transcriptase polymerase chain reaction (RT-PCR) is becoming a widely used method to quantify cytokines from cells, tissues, or tissue…”
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Discovery of Molecular Pathways Mediating 1,25-Dihydroxyvitamin D3 Protection Against Cytokine-Induced Inflammation and Damage of Human and Male Mouse Islets of Langerhans by Wolden-Kirk, H, Rondas, D, Bugliani, M, Korf, H, Van Lommel, L, Brusgaard, K, Christesen, H.T, Schuit, F, Proost, P, Masini, M, Marchetti, P, Eizirik, D.L, Overbergh, L, Mathieu, C

“…Protection against insulitis and diabetes by active vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), in nonobese diabetic mice has until now mainly been…”
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Platelet Gs hypofunction and abnormal morphology resulting from a heterozygous RGS2 mutation by NOÉ, L., DI MICHELE, M., GIETS, E., THYS, C., WITTEVRONGEL, C., DE VOS, R., OVERBERGH, L., WAELKENS, E., JAEKEN, J., VAN GEET, C., FRESON, K.

“…Background: Regulator of G‐protein signaling (RGS) 2 negatively regulates Gs signaling by inhibiting the activation of adenylyl cyclase (AC). RGS2 mRNA…”
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A proteomic approach on the effects of TX527, a 1α,25-dihydroxyvitamin D3 analog, in human T lymphocytes by Ferreira, G.B., Baeke, F., Verstuyf, A., De Clercq, P., Waelkens, E., Mathieu, C., Overbergh, L.

“…•TX527, a 1α,25(OH)2D3 analog, alters the global protein profile of human T cells.•TX527 affects proteins involved in energy/protein metabolism and…”
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The development of atopic dermatitis is independent of Immunoglobulin E up-regulation in the K14-IL-4 SKH1 transgenic mouse model by Chen, L., Overbergh, L., Mathieu, C., Chan, L. S.

“…Summary Background We have successfully generated an IgE‐associated (extrinsic/allergic) mouse model of atopic dermatitis in K14‐IL‐4‐Tg/CByB6 mice. The newly…”
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Identification and immune regulation of 25‐hydroxyvitamin D‐1‐α‐hydroxylase in murine macrophages by Overbergh, L., Decallonne, B., Valckx, D., Verstuyf, A., Depovere, J., Laureys, J., Rutgeerts, O., Saint‐Arnaud, R., Bouillon, R., Mathieu, C.

“…Receptors for 1,25(OH)2vitaminD3 are found in most immune cells and important immunological effects have been described in vitro, reflected by its capacity to…”
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1α, 25-Dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543) by OVERBERGH, L, DECALLONNE, B, WAER, M, RUTGEERTS, O, VALCKX, D, CASTEELS, K. M, LAUREYS, J, BOUILLON, R, MATHIEU, C

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Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack by Gysemans, C, Callewaert, H, Moore, F, Nelson-Holte, M, Overbergh, L, Eizirik, D. L, Mathieu, C

“…Aims/hypothesis IFN-γ, together with other inflammatory cytokines such as IL-1β and TNF-α, contributes to beta cell death in type 1 diabetes. We analysed the…”
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NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells by Stoffels, K, Overbergh, L, Giulietti, A, Kasran, A, Bouillon, R, Gysemans, C, Mathieu, C

“…During the development of type 1 diabetes, pancreatic beta-cells are subject to an immune attack, leading to their apoptotic or necrotic cell death. Apoptotic…”
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Combination of a 1,25-dihydroxyvitamin D3 analog and a bisphosphonate prevents experimental autoimmune encephalomyelitis and preserves bone by VAN ETTEN, E, BRANISTEANU, D. D, OVERBERGH, L, BOUILLON, R, VERSTUYF, A, MATHIEU, C

“…The vitamin D analog TX527 (19-nor-14,20-bis epi-23-yne-1,25(OH)(2)D(3)), decreased disease severity (P < 0.001) and postponed disease onset (P < 0.0001) in…”
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Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents by GYSEMANS, C, STOFFELS, K, GIULIETTI, A, OVERBERGH, L, WAER, M, LANNOO, M, FEIGE, U, MATHIEU, C

“…High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic…”
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