Search Results - "OVAA, H"

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells by Rückrich, T, Kraus, M, Gogel, J, Beck, A, Ovaa, H, Verdoes, M, Overkleeft, H S, Kalbacher, H, Driessen, C

“…Resistance towards the proteasome inhibitor bortezomib is poorly understood. We adapted the HL-60, ARH-77 and AMO-1 cell lines (myeloid leukemia, plasmocytoid…”
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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib by Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.

“…Bortezomib therapy has proven successful for the treatment of relapsed and/or refractory multiple myeloma (MM); however, prolonged treatment is associated with…”
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Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease by Nijholt, D A T, de Graaf, T R, van Haastert, E S, Oliveira, A Osório, Berkers, C R, Zwart, R, Ovaa, H, Baas, F, Hoozemans, J J M, Scheper, W

“…Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore cellular homeostasis…”
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Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials by Potts, B C, Albitar, M X, Anderson, K C, Baritaki, S, Berkers, C, Bonavida, B, Chandra, J, Chauhan, D, Cusack, Jr, J C, Fenical, W, Ghobrial, I M, Groll, M, Jensen, P R, Lam, K S, Lloyd, G K, McBride, W, McConkey, D J, Miller, C P, Neuteboom, S T C, Oki, Y, Ovaa, H, Pajonk, F, Richardson, P G, Roccaro, A M, Sloss, C M, Spear, M A, Valashi, E, Younes, A, Palladino, M A

“…The proteasome has emerged as an important clinically relevant target for the treatment of hematologic malignancies. Since the Food and Drug Administration…”
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Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate by Misaghi, Shahram, Galardy, Paul J., Meester, Wim J.N., Ovaa, Huib, Ploegh, Hidde L., Gaudet, Rachelle

“…Ubiquitin C-terminal hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function. Although no cellular substrates have been…”
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Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells by KRAUS, M, RUCKRICH, T, DRIESSEN, C, REICH, M, GOGEL, J, BECK, A, KAMMER, W, BERKERS, C. R, BURG, D, OVERKLEEFT, H, OVAA, H

“…Proteasomal proteolysis relies on the activity of six catalytically active proteasomal subunits (beta1, beta2, beta5, beta1i, beta2i and beta5i). Applying a…”
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An expeditious route to phosphorus heterocycles based on ring-closing metathesis by Timmer, Mattie S.M, Ovaa, Huib, Filippov, Dmitri V, van der Marel, Gijs A, van Boom, Jacques H

“…A convenient route for the synthesis of phosphorus diolefinic templates starting from the bifunctional reagent bis(diisopropylamino)vinylphosphine is…”
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Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome by Groll, Michael, Berkers, Celia R., Ploegh, Hidde L., Ovaa, Huib

“…The dipeptide boronic acid bortezomib, also termed VELCADE ®, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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LBA73 The ORF1ab of SARS-CoV-2 encodes an immunodominant epitope restricted by HLA-A01:01 by Kvistborg, P., Gangaev, A., Ketelaars, S., Patiweal, S., Dopler, A., Isaeva, O., Hoefakker, K., De Biasi, S., Mussini, C., Guaraldi, G., Girardis, M., Talavera Ormeno, C., Hekking, P., Lardy, N., Toebes, M., Balderas, R., Schumacher, T.N., Ovaa, H., Cossarizza, A.

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Selection and Use of Bio-Indicators to Assess the Possible Effects of Climate Change in Europe by de Groot, Rudolf S., Ketner, Pieter, Ovaa, Arjan H.

“…From paleoecological records it is well known that past climate changes have led to considerable changes in the species composition of ecosystems and larger…”
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Design and use of conditional MHC class I ligands by Ovaa, Huib, Schumacher, Ton N M, Toebes, Mireille, Coccoris, Miriam, Bins, Adriaan, Rodenko, Boris, Gomez, Raquel, Nieuwkoop, Nella J, van de Kasteele, Willeke, Rimmelzwaan, Guus F, Haanen, John B A G

“…Major histocompatibility complex (MHC) class I molecules associate with a variety of peptide ligands during biosynthesis and present these ligands on the cell…”
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Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis by Miyabe, Yoshishige, Miyabe, Chie, Iwai, Yoshiko, Takayasu, Aiko, Fukuda, Shin, Yokoyama, Waka, Nagai, Jun, Jona, Masahiro, Tokuhara, Yasunori, Ohkawa, Ryunosuke, Albers, Harald M., Ovaa, Huib, Aoki, Junken, Chun, Jerold, Yatomi, Yutaka, Ueda, Hiroshi, Miyasaka, Masayuki, Miyasaka, Nobuyuki, Nanki, Toshihiro

“…Objective Lysophosphatidic acid (LPA) is a bioactive lipid that binds to a group of cell surface G protein–coupled receptors (LPA receptors 1–6 [LPA1–6]) and…”
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Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome by Kristiansen, Mark, Deriziotis, Pelagia, Dimcheff, Derek E., Jackson, Graham S., Ovaa, Huib, Naumann, Heike, Clarke, Anthony R., van Leeuwen, Fijs W.B., Menéndez-Benito, Victoria, Dantuma, Nico P., Portis, John L., Collinge, John, Tabrizi, Sarah J.

“…The mechanism of cell death in prion disease is unknown but is associated with the production of a misfolded conformer of the prion protein. We report that…”
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Loss of HAUSP-Mediated Deubiquitination Contributes to DNA Damage-Induced Destabilization of Hdmx and Hdm2 by Meulmeester, Erik, Maurice, Madelon M., Boutell, Chris, Teunisse, Amina F.A.S., Ovaa, Huib, Abraham, Tsion E., Dirks, Roeland W., Jochemsen, Aart G.

“…The p53 tumor suppressor protein has a major role in protecting the integrity of the genome. In unstressed cells, p53 is maintained at low levels by the…”
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Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib by Ovaa, Huib, Berkers, Celia R, Verdoes, Martijn, Lichtman, Eben, Fiebiger, Edda, Kessler, Benedikt M, Anderson, Kenneth C, Ploegh, Hidde L, Galardy, Paul J

“…Proteasome inhibitors, such as the dipeptide boronic acid bortezomib, are emerging as important tools in the treatment of the fatal hematologic malignancy…”
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Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy by Birks, Emma J., Latif, Najma, Enesa, Karine, Folkvang, Tonje, Luong, Le Anh, Sarathchandra, Padmini, Khan, Mak, Ovaa, Huib, Terracciano, Cesare M., Barton, Paul J.R., Yacoub, Magdi H., Evans, Paul C.

“…Aims The molecular mechanisms that regulate cardiomyocyte apoptosis and their role in human heart failure (HF) are uncertain. Expression of the apoptosis…”
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Differential Dependence of CD4+ CD25+ Regulatory and Natural Killer-Like T Cells on Signals Leading to NF-κB Activation by Schmidt-Supprian, Marc, Tian, Jane, Grant, Ethan P., Pasparakis, Manolis, Maehr, René, Ovaa, Huib, Ploegh, Hidde L., Coyle, Anthony J., Rajewsky, Klaus

“…Natural killer-like (NK) T, regulatory T ( T R), and memory type T cells display surface phenotypes reminiscent of activated T cells. Previously, we reported…”
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Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity by Evans, Paul C, Ovaa, Huib, Hamon, Maureen, Kilshaw, Peter J, Hamm, Svetlana, Bauer, Stefan, Ploegh, Hidde L, Smith, Trevor S

“…Ubiquitination regulates the stability and/or activity of numerous cellular proteins. The corollary is that de-ubiquitinating enzymes, which 'trim'…”
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Immunotherapeutic potential for ceramide-based activators of iNKT cells by Berkers, Celia R., Ovaa, Huib

“…Invariant natural killer T (iNKT) cells are a subpopulation of T cells that are reactive with glycolipids that are bound by CD1d antigen-presenting molecules…”
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