Search Results - "OUWEHAND, W. H."

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome by Barber, T. M, Bennett, A. J, Groves, C. J, Sovio, U, Ruokonen, A, Martikainen, H, Pouta, A, Hartikainen, A.-L, Elliott, P, Lindgren, C. M, Freathy, R. M, Koch, K, Ouwehand, W. H, Karpe, F, Conway, G. S, Wass, J. A. H, Järvelin, M.-R, Franks, S, McCarthy, M. I

“…Aims/hypothesis Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity…”
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Nomenclature of human platelet antigens by Metcalfe, P., Watkins, N. A., Ouwehand, W. H., Kaplan, C., Newman, P., Kekomaki, R., De Haas, M., Aster, R., Shibata, Y., Smith, J., Kiefel, V., Santoso, S.

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A modified rapid monoclonal antibody-specific immobilization of platelet antigen assay for the detection of human platelet antigen (HPA) antibodies: a multicentre evaluation by Campbell, K., Rishi, K., Howkins, G., Gilby, D., Mushens, R., Ghevaert, C., Metcalfe, P., Ouwehand, W. H., Lucas, G.

“…Background  The monoclonal antibody‐specific immobilization of platelet antigens (MAIPA) assay is the cornerstone technique for the detection and…”
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Detection of Gov system antibodies by MAIPA reveals an immunogenicity similar to the HPA‐5 alloantigens by Berry, J. E., Murphy, C. M., Smith, G. A., Ranasinghe, E., Finberg, R., Walton, J., Brown, J., Navarrete, C., Metcalfe, P., Ouwehand, W. H.

“…The glycosylphosphatidylinositol‐linked platelet protein CD109 carries the biallelic alloantigen system Gov. There is limited information on the incidence of…”
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Genotyping for platelet-specific antigens: techniques for the detection of single nucleotide polymorphisms by Hurd, C. M., Cavanagh, G., Schuh, A., Ouwehand, W. H., Metcalfe, P.

“…Accurate typing of patients for platelet‐specific (human platelet) antigens (HPA) is required in several different clinical situations, and blood services need…”
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Reactome – a curated knowledgebase of biological pathways: megakaryocytes and platelets by JUPE, S., AKKERMAN, J. W., SORANZO, N., OUWEHAND, W. H.

“…The platelet field is undergoing a radical transformation from reductionist simplification to large scale integration. Following the era of simplification…”
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Gain‐ and loss‐of‐function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen by O'CONNOR, M. N., SMETHURST, P. A., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: By site‐directed mutagenesis of recombinant receptor fragments, we have previously identified residue lysine59 of the platelet collagen receptor…”
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Collaborative study to establish the first international standard for quantitation of anti-HPA-1a by Allen, D., Rigsby, P., Bessos, H., Berry, J., Wilson, D., Ouwehand, W. H., Urbaniak, S., Metcalfe, P.

“…Background and Objectives  This report describes the production of a freeze‐dried preparation of pooled human plasma, containing immunoglobulin G (IgG)…”
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Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in‐depth exon resequencing and genotyping with tag single nucleotide polymorphisms by WATKINS, N. A., O'CONNOR, M. N., RANKIN, A., JENNINGS, N., WILSON, E., HARMER, I. J., DAVIES, L., SMETHURST, P. A., DUDBRIDGE, F., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: Common genetic variants of cell surface receptors contribute to differences in functional responses and disease susceptibility. We have previously…”
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Provision of platelet support for fetuses and neonates affected by severe fetomaternal alloimmune thrombocytopenia by Ranasinghe, E., Walton, J. D., Hurd, C. M., Saul, L., Smith, G., Campbell, K., Ouwehand, W. H.

“…Severe fetomaternal alloimmune thrombocytopenia requires urgent treatment with compatible platelet concentrates. As prompt treatment is sometimes delayed owing…”
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Activation during preparation of therapeutic platelets affects deterioration during storage: a comparative flow cytometric study of different production methods by METCALFE, PAUL, WILLIAMSON, LORNA M., REUTELINGSPERGER, CHRIS P. M., SWANN, IAN, OUWEHAND, WILLEM H., GOODALL, ALISON H.

“…Three different separation methods, all using centrifugation, are routinely used to prepare therapeutic platelet concentrates from human donor blood. Platelet…”
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Adult respiratory distress syndrome after experimental intravenous γ-globulin concentrate and monocyte-reactive IgG antibodies by Kuijpers, RWAM, Dooren, MC, Ouwehand, WH, Verhoeven, AJ, von dem Borne, AEG Kr

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Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time by Garner, S. F., Furnell, A., Kahan, B. C., Jones, C. I., Attwood, A., Harrison, P., Kelly, A. M., Goodall, A. H., Cardigan, R., Ouwehand, W. H.

“…Background and Objectives Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the…”
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Interlaboratory variation in the detection of clinically significant alloantibodies against human platelet alloantigens by Metcalfe, P., Allen, D., Chapman, J., Ouwehand, W. H.

“…This report describes the results of eight workshop exercises which were designed to test the proficiency of laboratories in the detection of antibodies to…”
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The discovery of genes implicated in myocardial infarction by OUWEHAND, W. H.

“…The era of Genome‐Wide Association Studies (GWAS) commenced in 2007 with the study of the Wellcome Trust Case Control Consortium (WTCCC) which for the first…”
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Platelet genomics and the risk of atherothrombosis by OUWEHAND, W. H.

“…Platelets play a pivotal role in atherothrombosis after coronary artery plaque rupture. The extent of response of platelets to such an event varies between…”
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Collaborative studies to establish the first WHO Reference Reagent for detection of human antibody against human platelet antigen-5b by Metcalfe, P., Ouwehand, W. H., Sands, D., Barrowcliffe, T. W.

“…Background and Objectives This report describes the production of a freeze‐dried preparation of pooled human plasma, coded 99/666, containing immunoglobulin G…”
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Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain by Basu, B., Correa de Sampaio, P., Mohammed, H., Fogarasi, M., Corrie, P., Watkins, N.A., Smethurst, P.A., English, W.R., Ouwehand, W.H., Murphy, G.

“…The membrane associated MMP, MT1-MMP, is a critical pericellular protease involved in tumour cell invasion and angiogenesis and is highly up-regulated in…”
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A Human Monoclonal Antibody Specific for the Leucine-33 (P1A1, HPA-1a) Form of Platelet Glycoprotein IIIa From a V Gene Phage Display Library by Griffin, Heather M., Ouwehand, Willem H.

“…IgG alloantibodies to polymorphic platelet glycoproteins (GPs) are known to be responsible for severe thrombocytopenia in the neonate and after transfusion…”
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Human autoimmune anti‐proteinase 3 scFv from a phage display library by FINNERN, R., PEDROLLO, E., FISCH, I., WIESLANDER, J., MARKS, J. D., LOCKWOOD, C. M., OUWEHAND, W. H.

“…This is the first study describing recombinant human antibody fragments directed to the autoantigen proteinase 3 (PR3) from an immune B cell source. Detection…”
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